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Overview
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1.9

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_LR593888.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | NRPS-like | 117,802 | 159,946 |
Region 2 | terpene | 1,905,541 | 1,925,595 |
Region 3 | terpene | 2,257,653 | 2,279,363 |
Region 4 | terpene | 4,265,208 | 4,285,159 |
Region 5 | terpene | 6,196,581 | 6,217,486 |
Region 6 | T3PKS | 6,340,598 | 6,381,701 | hierridin B / hierridin C | Polyketide | 28%
Region 7 | hglE-KS | 6,922,324 | 6,968,002 |
Region 8 | NRPS-like | 7,873,150 | 7,917,097 |
Region 9 | hglE-KS,T1PKS | 8,859,731 | 8,913,406 | eicoseicosapentaenoic acid | Other | 21%

NZ_LR593888.1 - Region 1 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 117,802 - 159,946 nt. (total: 42,145 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000597.1 |  | 0.13 | RiPP | SWA-2138 | Streptomyces sp. e14
BGC0000595.1 |  | 0.13 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.13 | RiPP | SLI-2138 | Streptomyces lividans TK24
BGC0001560.1 |  | 0.09 | NRP, Polyketide | cryptomaldamide | Moorea producens JHB
BGC0000383.1 |  | 0.08 | NRP, Polyketide | luminmycin A | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001515.1 |  | 0.08 | NRP | aspercryptins | Aspergillus nidulans FGSC A4
BGC0001007.1 |  | 0.07 | Polyketide, NRP | lymphostin, neolymphostinol B, lymphostinol, neolymphostin b | Salinispora arenicola CNS-205
BGC0001006.1 |  | 0.07 | NRP, Polyketide | lymphostin, neolymphostinol B, lymphostinol, neolymphostin B | Salinispora tropica CNB-440
BGC0000958.1 |  | 0.06 | NRP, Polyketide | antimycin | Streptomyces sp. S4
BGC0001216.1 |  | 0.06 | NRP, Polyketide | splenocin | Streptomyces sp. CNQ431

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000597.1 |  | 0.42 | RiPP | SWA-2138 | Streptomyces sp. e14
BGC0000595.1 |  | 0.42 | RiPP | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000596.1 |  | 0.42 | RiPP | SLI-2138 | Streptomyces lividans TK24
BGC0001560.1 |  | 0.34 | NRP, Polyketide | cryptomaldamide | Moorea producens JHB
BGC0000383.1 |  | 0.31 | NRP, Polyketide | luminmycin A | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001515.1 |  | 0.31 | NRP | aspercryptins | Aspergillus nidulans FGSC A4
BGC0001007.1 |  | 0.28 | Polyketide, NRP | lymphostin, neolymphostinol B, lymphostinol, neolymphostin b | Salinispora arenicola CNS-205
BGC0001006.1 |  | 0.28 | NRP, Polyketide | lymphostin, neolymphostinol B, lymphostinol, neolymphostin B | Salinispora tropica CNB-440
BGC0000958.1 |  | 0.25 | NRP, Polyketide | antimycin | Streptomyces sp. S4
BGC0001216.1 |  | 0.25 | NRP, Polyketide | splenocin | Streptomyces sp. CNQ431

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LR593888.1 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,905,541 - 1,925,595 nt. (total: 20,055 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000846.1 |  | 0.26 | Other | tabtoxin | Pseudomonas syringae
BGC0000646.1 |  | 0.21 | Terpene | β-carotein | uncultured bacterium
BGC0000885.1 |  | 0.21 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000634.1 |  | 0.21 | Terpene | carotenoid | Brevundimonas sp. SD212
BGC0000643.1 |  | 0.21 | Terpene | carotenoid | Brevundimonas vesicularis
BGC0000630.1 |  | 0.20 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000640.1 |  | 0.19 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0001227.1 |  | 0.19 | Terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000656.1 |  | 0.19 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000641.1 |  | 0.18 | Terpene | carotenoid | Enterobacteriaceae bacterium DC416

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000846.1 |  | 0.60 | Other | tabtoxin | Pseudomonas syringae
BGC0000646.1 |  | 0.54 | Terpene | β-carotein | uncultured bacterium
BGC0000885.1 |  | 0.54 | Other | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000634.1 |  | 0.54 | Terpene | carotenoid | Brevundimonas sp. SD212
BGC0000643.1 |  | 0.53 | Terpene | carotenoid | Brevundimonas vesicularis
BGC0000630.1 |  | 0.52 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000640.1 |  | 0.52 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0001227.1 |  | 0.51 | Terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000656.1 |  | 0.50 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000641.1 |  | 0.50 | Terpene | carotenoid | Enterobacteriaceae bacterium DC416

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LR593888.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,257,653 - 2,279,363 nt. (total: 21,711 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001120.1 |  | 0.18 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001588.1 |  | 0.17 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0001589.1 |  | 0.16 | Saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0001248.1 |  | 0.14 | Terpene | clavaric acid | Hypholoma sublateritium
BGC0000686.1 |  | 0.14 | Terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001317.1 |  | 0.14 | Terpene | lupeol | Lotus japonicus
BGC0001400.1 |  | 0.13 | Polyketide | citreoviridin | Aspergillus terreus NIH2624
BGC0001838.1 |  | 0.07 | NRP | WLIP | Pseudomonas putida
BGC0001103.1 |  | 0.05 | NRP, Polyketide | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002025.1 |  | 0.04 | NRP | thaxteramide C | Jahnella sp. MSr9139

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001120.1 |  | 0.49 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001588.1 |  | 0.48 | Saccharide | exopolysaccharides | Burkholderia pseudomallei 1026b
BGC0001589.1 |  | 0.46 | Saccharide | exopolysaccharides | Burkholderia cenocepacia J2315
BGC0001248.1 |  | 0.44 | Terpene | clavaric acid | Hypholoma sublateritium
BGC0000686.1 |  | 0.43 | Terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001317.1 |  | 0.43 | Terpene | lupeol | Lotus japonicus
BGC0001400.1 |  | 0.42 | Polyketide | citreoviridin | Aspergillus terreus NIH2624
BGC0001838.1 |  | 0.29 | NRP | WLIP | Pseudomonas putida
BGC0001103.1 |  | 0.21 | NRP, Polyketide | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002025.1 |  | 0.19 | NRP | thaxteramide C | Jahnella sp. MSr9139

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LR593888.1 - Region 4 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,265,208 - 4,285,159 nt. (total: 19,952 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001607.1 |  | 0.13 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0001540.1 |  | 0.13 | Other | CC-1065 | Streptomyces zelensis
BGC0001911.1 |  | 0.12 | Terpene | raimonol | Streptomyces anulatus
BGC0000642.1 |  | 0.10 | Terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001167.1 |  | 0.10 | RiPP | piricyclamide | Microcystis aeruginosa PCC 7005
BGC0000678.1 |  | 0.08 | Terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000636.1 |  | 0.08 | Terpene | carotenoid | Brevibacterium linens
BGC0000651.1 |  | 0.07 | Terpene | KS-505a | Streptomyces argenteolus
BGC0001595.1 |  | 0.07 | Alkaloid | fischerindole | Fischerella sp. SAG 46.79
BGC0001594.1 |  | 0.07 | Alkaloid | fischerindole L | Fischerella muscicola UTEX 1829

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001607.1 |  | 0.42 | Other | gilvusmycin | Streptomyces sp. NRRL B-1347
BGC0001540.1 |  | 0.41 | Other | CC-1065 | Streptomyces zelensis
BGC0001911.1 |  | 0.39 | Terpene | raimonol | Streptomyces anulatus
BGC0000642.1 |  | 0.36 | Terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001167.1 |  | 0.35 | RiPP | piricyclamide | Microcystis aeruginosa PCC 7005
BGC0000678.1 |  | 0.30 | Terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000636.1 |  | 0.30 | Terpene | carotenoid | Brevibacterium linens
BGC0000651.1 |  | 0.29 | Terpene | KS-505a | Streptomyces argenteolus
BGC0001595.1 |  | 0.29 | Alkaloid | fischerindole | Fischerella sp. SAG 46.79
BGC0001594.1 |  | 0.28 | Alkaloid | fischerindole L | Fischerella muscicola UTEX 1829

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LR593888.1 - Region 5 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 6,196,581 - 6,217,486 nt. (total: 20,906 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.29 | Terpene | carotenoid | Myxococcus xanthus
BGC0001903.1 |  | 0.11 | Other | neocarazostatin A | Streptomyces sp. MA37

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.62 | Terpene | carotenoid | Myxococcus xanthus
BGC0001903.1 |  | 0.38 | Other | neocarazostatin A | Streptomyces sp. MA37

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LR593888.1 - Region 6 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 6,340,598 - 6,381,701 nt. (total: 41,104 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001938.1 |  | 0.37 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0000282.1 |  | 0.32 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.1 |  | 0.30 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001831.1 |  | 0.23 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001285.1 |  | 0.21 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000783.1 |  | 0.16 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0001540.1 |  | 0.14 | Other | CC-1065 | Streptomyces zelensis
BGC0000882.1 |  | 0.14 | Other | mildiomycin | Streptomyces rimofaciens
BGC0000207.1 |  | 0.14 | Polyketide | chartreusin | Streptomyces chartreusis
BGC0002009.1 |  | 0.14 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001938.1 |  | 0.70 | Polyketide | entotheonella | Candidatus Entotheonella serta
BGC0000282.1 |  | 0.65 | Polyketide | alkylresorcinol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.1 |  | 0.64 | Polyketide | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001831.1 |  | 0.56 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001285.1 |  | 0.53 | Other (Fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0000783.1 |  | 0.47 | Saccharide | O-antigen | Xanthomonas oryzae pv. oryzae
BGC0001540.1 |  | 0.44 | Other | CC-1065 | Streptomyces zelensis
BGC0000882.1 |  | 0.44 | Other | mildiomycin | Streptomyces rimofaciens
BGC0000207.1 |  | 0.43 | Polyketide | chartreusin | Streptomyces chartreusis
BGC0002009.1 |  | 0.43 | Polyketide | kanglemycin A, kanglemycin V1, kanglemycin V2 | Amycolatopsis vancoresmycina

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_LR593888.1 - Region 7 - hglE-KS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 6,922,324 - 6,968,002 nt. (total: 45,679 nt) Show pHMM detection rules used
hglE-KS: (hglE or hglD)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hglE-KS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000861.1 |  | 0.26 | Other | eicosapentaenoic acid | Shewanella sp. BR-2
BGC0000862.1 |  | 0.26 | Other | eicosapentaenoic acid | Shewanella pneumatophori
BGC0000863.1 |  | 0.25 | Other | eicosapentaenoic acid | Pseudoalteromonas sp. DS-12
BGC0000056.1 |  | 0.24 | Polyketide | esperamicin | Actinomadura verrucosospora
BGC0000869.1 |  | 0.23 | Other | heterocyst glycolipids | Nostoc sp. 'Peltigera membranacea cyanobiont'
BGC0001338.1 |  | 0.21 | Polyketide | citrinin | Monascus ruber
BGC0000864.1 |  | 0.20 | Other | eicosapentaenoic acid-like compound | Moritella marina ATCC 15381
BGC0001872.1 |  | 0.20 | Polyketide | fabclavine-polyamine | Xenorhabdus bovienii SS-2004
BGC0000140.1 |  | 0.20 | Polyketide | 4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one | Streptomyces sp. 88-682
BGC0000022.1 |  | 0.17 | Polyketide | asperfuranone | Aspergillus nidulans FGSC A4

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000861.1 |  | 0.59 | Other | eicosapentaenoic acid | Shewanella sp. BR-2
BGC0000862.1 |  | 0.59 | Other | eicosapentaenoic acid | Shewanella pneumatophori
BGC0000863.1 |  | 0.58 | Other | eicosapentaenoic acid | Pseudoalteromonas sp. DS-12
BGC0000056.1 |  | 0.58 | Polyketide | esperamicin | Actinomadura verrucosospora
BGC0000869.1 |  | 0.56 | Other | heterocyst glycolipids | Nostoc sp. 'Peltigera membranacea cyanobiont'
BGC0001338.1 |  | 0.54 | Polyketide | citrinin | Monascus ruber
BGC0000864.1 |  | 0.53 | Other | eicosapentaenoic acid-like compound | Moritella marina ATCC 15381
BGC0001872.1 |  | 0.52 | Polyketide | fabclavine-polyamine | Xenorhabdus bovienii SS-2004
BGC0000140.1 |  | 0.52 | Polyketide | 4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one | Streptomyces sp. 88-682
BGC0000022.1 |  | 0.48 | Polyketide | asperfuranone | Aspergillus nidulans FGSC A4

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 6922323 - 6968002:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_5838: mal
  PKS_AT (1259..1555): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 70.8%
    inactive: 58.3%
    Methylmalonyl-CoA: 54.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 80.8
    Methylmalonyl-CoA: 46.1
    Methoxymalonyl-CoA: 42.8
    inactive: 32.6
    Propionyl-CoA: 24.3
    fatty_acid: 16.9
    Ethylmalonyl-CoA: 14.7
    CHC-CoA: 14.1
    trans-1,2-CPDA: 12.0
    Benzoyl-CoA: 8.7
    Isobutyryl-CoA: 7.5
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg1_5839: mal
  PKS_AT (121..426): mal
  ATSignature: (unknown)
  No matches above 50%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 12.3
    trans-1,2-CPDA: 0.0
    inactive: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methoxymalonyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
    Methylmalonyl-CoA: -0.5

NZ_LR593888.1 - Region 8 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 7,873,150 - 7,917,097 nt. (total: 43,948 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.33 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.30 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000900.1 |  | 0.28 | Other | ferrichrome | Aspergillus oryzae
BGC0001561.1 |  | 0.26 | NRP | curacomycin | Streptomyces curacoi
BGC0000979.1 |  | 0.25 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.25 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001479.1 |  | 0.24 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000348.1 |  | 0.24 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001718.1 |  | 0.22 | NRP | okaramine D | Aspergillus aculeatus ATCC 16872
BGC0000876.1 |  | 0.21 | Other | neopolyoxin C | Streptomyces tendae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.66 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.63 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000900.1 |  | 0.61 | Other | ferrichrome | Aspergillus oryzae
BGC0001561.1 |  | 0.60 | NRP | curacomycin | Streptomyces curacoi
BGC0000979.1 |  | 0.59 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 10E9
BGC0000980.1 |  | 0.59 | NRP, Polyketide | cylindrospermopsin | Aphanizomenon sp. 22D11
BGC0001479.1 |  | 0.57 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000348.1 |  | 0.57 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001718.1 |  | 0.55 | NRP | okaramine D | Aspergillus aculeatus ATCC 16872
BGC0000876.1 |  | 0.53 | Other | neopolyoxin C | Streptomyces tendae

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location 7873149 - 7917097:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_6638: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (9..407): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      glu
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DsechGdVVK
    Nearest Stachelhaus code:
      leu
    Stachelhaus code match:
      50% (weak)

NZ_LR593888.1 - Region 9 - T1PKS,hglE-KS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 8,859,731 - 8,913,406 nt. (total: 53,676 nt) Show pHMM detection rules used
hglE-KS: (hglE or hglD)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hglE-KS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000863.1 |  |  | 0.55 | Other | eicosapentaenoic acid | Pseudoalteromonas sp. DS-12
BGC0000140.1 |  |  | 0.52 | Polyketide | 4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one | Streptomyces sp. 88-682
BGC0000027.1 |  |  | 0.49 | Polyketide | ankaflavin, monascin, rubropunctatine, monascorubrin | Monascus pilosus
BGC0001338.1 |  |  | 0.49 | Polyketide | citrinin | Monascus ruber
BGC0000056.1 |  |  | 0.49 | Polyketide | esperamicin | Actinomadura verrucosospora
BGC0000284.1 |  |  | 0.48 | Polyketide | phenolic lipids | Azotobacter vinelandii DJ
BGC0001977.1 |  |  | 0.44 | Other | eupenifeldin | Phoma sp.
BGC0001976.1 |  |  | 0.44 | Terpene | eupenifeldin | Phoma sp.
BGC0000204.1 |  |  | 0.43 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0001872.1 |  |  | 0.43 | Polyketide | fabclavine-polyamine | Xenorhabdus bovienii SS-2004

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000863.1 |  | 0.61 | Other | eicosapentaenoic acid | Pseudoalteromonas sp. DS-12
BGC0000140.1 |  | 0.60 | Polyketide | 4-hexadecanoyl-3-hydroxy-2-(hydroxymethyl)-2H-furan-5-one | Streptomyces sp. 88-682
BGC0000027.1 |  | 0.58 | Polyketide | ankaflavin, monascin, rubropunctatine, monascorubrin | Monascus pilosus
BGC0001338.1 |  | 0.58 | Polyketide | citrinin | Monascus ruber
BGC0000056.1 |  | 0.58 | Polyketide | esperamicin | Actinomadura verrucosospora
BGC0000284.1 |  | 0.57 | Polyketide | phenolic lipids | Azotobacter vinelandii DJ
BGC0001977.1 |  | 0.55 | Other | eupenifeldin | Phoma sp.
BGC0001976.1 |  | 0.55 | Terpene | eupenifeldin | Phoma sp.
BGC0000204.1 |  | 0.54 | Polyketide | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0001872.1 |  | 0.54 | Polyketide | fabclavine-polyamine | Xenorhabdus bovienii SS-2004

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 9, location 8859730 - 8913406:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_7463: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (12..468): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      --fFIAppVK
    Nearest Stachelhaus code:
      pro
    Stachelhaus code match:
      50% (weak)
ctg1_7466: pk
  PKS_AT (955..1251): pk
  ATSignature: (unknown)
  No matches above 50%
  minowa: trans-1,2-CPDA
  Prediction, score:
    trans-1,2-CPDA: 0.0
    inactive: 0.0
    fatty_acid: 0.0
    Propionyl-CoA: 0.0
    Methylmalonyl-CoA: 0.0
    Methoxymalonyl-CoA: 0.0
    Malonyl-CoA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0
ctg1_7467: mal
  PKS_AT (584..887): mal
  ATSignature: Malonyl-CoA
  Top 3 matches:
    Malonyl-CoA: 70.8%
    inactive: 54.2%
  minowa: Malonyl-CoA
  Prediction, score:
    Malonyl-CoA: 69.3
    Methoxymalonyl-CoA: 32.7
    Methylmalonyl-CoA: 30.3
    Propionyl-CoA: 22.4
    inactive: 19.4
    fatty_acid: 13.0
    trans-1,2-CPDA: 0.0
    Isobutyryl-CoA: 0.0
    Ethylmalonyl-CoA: 0.0
    CHC-CoA: 0.0
    Benzoyl-CoA: 0.0
    Acetyl-CoA: 0.0
    3-Methylbutyryl-CoA: 0.0
    2-Methylbutyryl-CoA: 0.0