LOCUS       NZ_AP022547.1          10624 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_AP022547.1 Klebsiella michiganensis strain THO-011 chromosome,
            complete genome.
ACCESSION   NZ_AP022547
VERSION     NZ_AP022547.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:04:02
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 5862775
            Orig. end    :: 5873399
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10624
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5867775:5868399](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5624)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10624
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10624
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(866..3655)
                     /locus_tag="ctg1_5337"
                     /transl_table=11
                     /translation="MVQIPEKPLILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNM
                     LRSLILQYQPTHAVVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVKAMGL
                     PLMAVPGVEADDVIGTLAREAEKVGRPVLISTGDKDMAQLVTPGITLINTMTNTILGPD
                     EVVTKYGVPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAEPEKIA
                     GLTFRGAKTMAAKLEQNKEVAYLSYQLATIKTDVELELGCEDLLVAQPVADELLTLFKK
                     YEFKRWITDVESGKWMQAKGAKPAAKAVVAVADVADAEEETATALSSENYVTILDEETL
                     LTWVESLKKAPLFAFDTETDSLDNVSANMVGLSFAIEPGVAAYVPVAHDYLDAPDQIPR
                     DRVLELLKPLLEDDKVLKVGQNLKYDRGILANYGIELRGIAFDTMLESYILDSVAGRHD
                     MDSLSDRWLKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPEL
                     QQNEGPLNVFKNIEMPLVPVLSRVERNGVKIDPAVLHAHSQEIAKRLIELEKKAYDIAG
                     EEFNLSSPKQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLA
                     KLKSTYTDKLPLMISPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAF
                     IAPEDYLIVSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLESVSSE
                     QRRSAKAINFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRTQAKE
                     QGYVETLDGRRLYLPDIKSSNGARRAGAERAAINAPMQGTAADIIKRAMIAVDSWLLSE
                     KPRVRMIMQVHDELVFEVHKDDLEAVAKKIHELMESSTTLAVPLLVEVGSGENWDQAH"
     aSDomain        complement(869..3631)
                     /aSDomain="TIGR00593"
                     /aSTool="tigrfam"
                     /description="pola: DNA polymerase I"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_5337_0046"
                     /evalue="4.10E-287"
                     /identifier="TIGR00593"
                     /label="ctg1_5337"
                     /locus_tag="ctg1_5337"
                     /protein_end="929"
                     /protein_start="8"
                     /score="953.2"
                     /tool="antismash"
                     /translation="LILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLILQY
                     QPTHAVVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVKAMGLPLMAVPGV
                     EADDVIGTLAREAEKVGRPVLISTGDKDMAQLVTPGITLINTMTNTILGPDEVVTKYGV
                     PPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLYAEPEKIAGLTFRGAK
                     TMAAKLEQNKEVAYLSYQLATIKTDVELELGCEDLLVAQPVADELLTLFKKYEFKRWIT
                     DVESGKWMQAKGAKPAAKAVVAVADVADAEEETATALSSENYVTILDEETLLTWVESLK
                     KAPLFAFDTETDSLDNVSANMVGLSFAIEPGVAAYVPVAHDYLDAPDQIPRDRVLELLK
                     PLLEDDKVLKVGQNLKYDRGILANYGIELRGIAFDTMLESYILDSVAGRHDMDSLSDRW
                     LKHKTITFEEIAGKGKNQLTFNQIALEEAGRYAAEDADVTLQLHLKMWPELQQNEGPLN
                     VFKNIEMPLVPVLSRVERNGVKIDPAVLHAHSQEIAKRLIELEKKAYDIAGEEFNLSSP
                     KQLQTILFEKQGIKPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTD
                     KLPLMISPKTGRVHTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYLI
                     VSADYSQIELRIMAHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLESVSSEQRRSAKAI
                     NFGLIYGMSAFGLARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRTQAKEQGYVETLD
                     GRRLYLPDIKSSNGARRAGAERAAINAPMQGTAADIIKRAMIAVDSWLLSEKPRVRMIM
                     QVHDELVFEVHKDDLEAVAKKIHELMESSTTLAVPLLVEVGSGENWDQAH"
     PFAM_domain     complement(878..1999)
                     /aSDomain="DNA_pol_A"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00476.22"
                     /description="DNA polymerase family A"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_5337_0210"
                     /evalue="2.00E-158"
                     /label="ctg1_5337"
                     /locus_tag="ctg1_5337"
                     /protein_end="926"
                     /protein_start="552"
                     /score="527.5"
                     /tool="antismash"
                     /translation="LHAHSQEIAKRLIELEKKAYDIAGEEFNLSSPKQLQTILFEKQGI
                     KPLKKTPGGAPSTSEEVLEELALDYPLPKVILEYRGLAKLKSTYTDKLPLMISPKTGRV
                     HTSYHQAVTATGRLSSTDPNLQNIPVRNEEGRRIRQAFIAPEDYLIVSADYSQIELRIM
                     AHLSRDKGLLTAFAEGKDIHRATAAEVFGLPLESVSSEQRRSAKAINFGLIYGMSAFGL
                     ARQLNIPRKEAQKYMDLYFERYPGVLEYMERTRTQAKEQGYVETLDGRRLYLPDIKSSN
                     GARRAGAERAAINAPMQGTAADIIKRAMIAVDSWLLSEKPRVRMIMQVHDELVFEVHKD
                     DLEAVAKKIHELMESSTTLAVPLLVEVGSGENWD"
     PFAM_domain     complement(2102..2665)
                     /aSDomain="DNA_pol_A_exo1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01612.22"
                     /description="3'-5' exonuclease"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_5337_0209"
                     /evalue="6.90E-43"
                     /label="ctg1_5337"
                     /locus_tag="ctg1_5337"
                     /protein_end="518"
                     /protein_start="330"
                     /score="146.5"
                     /tool="antismash"
                     /translation="YVTILDEETLLTWVESLKKAPLFAFDTETDSLDNVSANMVGLSFA
                     IEPGVAAYVPVAHDYLDAPDQIPRDRVLELLKPLLEDDKVLKVGQNLKYDRGILANYGI
                     ELRGIAFDTMLESYILDSVAGRHDMDSLSDRWLKHKTITFEEIAGKGKNQLTFNQIALE
                     EAGRYAAEDADVTLQLHLKMWPELQ"
     PFAM_domain     complement(2846..3145)
                     /aSDomain="5_3_exonuc"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01367.22"
                     /description="5'-3' exonuclease, C-terminal SAM fold"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_5337_0208"
                     /evalue="2.20E-29"
                     /label="ctg1_5337"
                     /locus_tag="ctg1_5337"
                     /protein_end="270"
                     /protein_start="170"
                     /score="102.0"
                     /tool="antismash"
                     /translation="VPPELIIDFLALMGDSSDNIPGVPGVGEKTAQALLQGLGGLDTLY
                     AEPEKIAGLTFRGAKTMAAKLEQNKEVAYLSYQLATIKTDVELELGCEDLLVAQP"
     PFAM_domain     complement(3146..3631)
                     /aSDomain="5_3_exonuc_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02739.18"
                     /description="5'-3' exonuclease, N-terminal resolvase-like
                     domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_5337_0207"
                     /evalue="2.40E-54"
                     /label="ctg1_5337"
                     /locus_tag="ctg1_5337"
                     /protein_end="170"
                     /protein_start="8"
                     /score="183.6"
                     /tool="antismash"
                     /translation="LILVDGSSYLYRAYHAFPPLTNSAGEPTGAMYGVLNMLRSLILQY
                     QPTHAVVVFDAKGKTFRDELFEHYKSHRPPMPDDLRAQIEPLHAMVKAMGLPLMAVPGV
                     EADDVIGTLAREAEKVGRPVLISTGDKDMAQLVTPGITLINTMTNTILGPDEVVTKYG"
     CDS             4052..4951
                     /locus_tag="ctg1_5338"
                     /transl_table=11
                     /translation="MSRLLAAITLPLSIALTIIVTIICSVPIIVAGLIKLLVPIPAVWR
                     SISVFCNFMMYCWCEGLALLLPLNPWLKWDIQGLDGLNKKNWYLLISNHHSWADIVVLC
                     VLFRKHIPMNKYFLKQQLAWVPFIGLACWALDMPFMRRYSRGYLLRHPERRGKDVETTR
                     RSCEKFRAHPTTIVNFVEGSRFTEEKQQQARSPYQNLLSPKAAGIAMALSVLGSQFDKL
                     LNVTLCYPENNQKPFYDMLSGRLTRIVVRVSLEPVTEELHGDYVNDKNFKRRFQRWLNR
                     LWEEKDRQLTEIMQQAEK"
     PFAM_domain     4277..4645
                     /aSDomain="Acyltransferase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01553.23"
                     /description="Acyltransferase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_5338_0211"
                     /evalue="1.40E-11"
                     /label="ctg1_5338"
                     /locus_tag="ctg1_5338"
                     /protein_end="198"
                     /protein_start="75"
                     /score="44.2"
                     /tool="antismash"
                     /translation="IQGLDGLNKKNWYLLISNHHSWADIVVLCVLFRKHIPMNKYFLKQ
                     QLAWVPFIGLACWALDMPFMRRYSRGYLLRHPERRGKDVETTRRSCEKFRAHPTTIVNF
                     VEGSRFTEEKQQQARSPYQ"
     CDS             complement(5001..5624)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03651"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_5339"
                     /sec_met_domain="TIGR03651 (E-value: 0.0004, bitscore:
                     18.9, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIWLALAGMILAFSASAAQITDGKQYITLDKPVAGEPQVLEFF
                     SFYCPHCYQFEEVLHVSDNVKKKLPEGVKMTKYHVEFLGPLGKDLTQAWAVAMALGVED
                     KITVPMFEAVQKNQTVQTVADIRKVFVDAGVKGEDYDAAWNSFVVKSLVAQQEKAAADF
                     QLQGVPAMYVNGKYQLNPQGMDTSNMDAFVAQYADAVKQLVEKK"
     PFAM_domain     complement(5037..5507)
                     /aSDomain="DSBA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01323.22"
                     /description="DSBA-like thioredoxin domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_5339_0212"
                     /evalue="1.40E-28"
                     /label="ctg1_5339"
                     /locus_tag="ctg1_5339"
                     /protein_end="196"
                     /protein_start="39"
                     /score="100.1"
                     /tool="antismash"
                     /translation="QVLEFFSFYCPHCYQFEEVLHVSDNVKKKLPEGVKMTKYHVEFLG
                     PLGKDLTQAWAVAMALGVEDKITVPMFEAVQKNQTVQTVADIRKVFVDAGVKGEDYDAA
                     WNSFVVKSLVAQQEKAAADFQLQGVPAMYVNGKYQLNPQGMDTSNMDAFVAQY"
     CDS             complement(5652..6638)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_5340"
                     /sec_met_domain="APH (E-value: 3.5e-42, bitscore: 143.3,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHDKAFTFQTLHPDTIIDGLFDLGMRVDSGLTPLNSYENRVYQFQ
                     DEDRRRYVVKFYRPERWSAQQILEEHQFSLQLVQDEVPVAAPLSFNNSTLHQHQGFFFA
                     VFPSLGGRQFEADNLDQMEWVGRYLGRLHQTGRKQRFVARPEIGTNEYLLEPRQVFELS
                     PLIPAGLKEAFLSATDKLIDAVMAQWHGRANILRLHGDCHAGNILWRDGPLFVDLDDSR
                     NGPAIQDLWMLLNGDKAEQRMQLEMIIEAYEEFSAFNTDEIALIEPLRAMRLVYYLAWL
                     LRRWEDPAFPKNFPWLTGEDYWRGQTTTFLEQVKVLQEPPLQLTPMY"
     PFAM_domain     complement(5871..6545)
                     /aSDomain="APH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01636.25"
                     /description="Phosphotransferase enzyme family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_5340_0213"
                     /evalue="2.20E-42"
                     /label="ctg1_5340"
                     /locus_tag="ctg1_5340"
                     /protein_end="256"
                     /protein_start="31"
                     /score="145.6"
                     /tool="antismash"
                     /translation="TPLNSYENRVYQFQDEDRRRYVVKFYRPERWSAQQILEEHQFSLQ
                     LVQDEVPVAAPLSFNNSTLHQHQGFFFAVFPSLGGRQFEADNLDQMEWVGRYLGRLHQT
                     GRKQRFVARPEIGTNEYLLEPRQVFELSPLIPAGLKEAFLSATDKLIDAVMAQWHGRAN
                     ILRLHGDCHAGNILWRDGPLFVDLDDSRNGPAIQDLWMLLNGDKAEQRMQLEMIIEAYE
                     EFS"
     CDS             complement(6714..6983)
                     /locus_tag="ctg1_5341"
                     /transl_table=11
                     /translation="MKCKRLNEVIELLQPAWQKEPELNLMQFLQKLAKEAGYTGELNDL
                     SDDILIYHLKMRDSAKEAVIPGIQKDYEEDFKTALLRARGVIKE"
     PFAM_domain     complement(6726..6983)
                     /aSDomain="DUF1040"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06288.15"
                     /description="Protein of unknown function (DUF1040)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_5341_0214"
                     /evalue="8.60E-46"
                     /label="ctg1_5341"
                     /locus_tag="ctg1_5341"
                     /protein_end="86"
                     /protein_start="0"
                     /score="154.3"
                     /tool="antismash"
                     /translation="MKCKRLNEVIELLQPAWQKEPELNLMQFLQKLAKEAGYTGELNDL
                     SDDILIYHLKMRDSAKEAVIPGIQKDYEEDFKTALLRARGV"
     CDS             7055..7636
                     /locus_tag="ctg1_5342"
                     /transl_table=11
                     /translation="MQGKVITGVVLAGGRGSRMGGIDKGLQLLKGKALWRHVADALQPQ
                     VTKLVISANRNLDCWRSSGYPIITDSLNDFPGPLAGMLSVMHQVEGEWFLFCPCDTPFI
                     PSFLATRLIQQRKSSPAVWVHDGERDHPAIALVNREAIGELETYLAAGERRVMVFLRKI
                     GGHSVDFSDVKSAFINVNTLDDLQRMQVPS"
     aSDomain        7070..7615
                     /aSDomain="TIGR02665"
                     /aSTool="tigrfam"
                     /description="molyb_mobA: molybdenum cofactor
                     guanylyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_5342_0047"
                     /evalue="6.50E-66"
                     /identifier="TIGR02665"
                     /label="ctg1_5342"
                     /locus_tag="ctg1_5342"
                     /protein_end="187"
                     /protein_start="5"
                     /score="219.9"
                     /tool="antismash"
                     /translation="ITGVVLAGGRGSRMGGIDKGLQLLKGKALWRHVADALQPQVTKLV
                     ISANRNLDCWRSSGYPIITDSLNDFPGPLAGMLSVMHQVEGEWFLFCPCDTPFIPSFLA
                     TRLIQQRKSSPAVWVHDGERDHPAIALVNREAIGELETYLAAGERRVMVFLRKIGGHSV
                     DFSDVKSAFINVNTLDDLQ"
     PFAM_domain     7076..7528
                     /aSDomain="NTP_transf_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12804.9"
                     /description="MobA-like NTP transferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_5342_0215"
                     /evalue="2.10E-30"
                     /label="ctg1_5342"
                     /locus_tag="ctg1_5342"
                     /protein_end="158"
                     /protein_start="7"
                     /score="106.3"
                     /tool="antismash"
                     /translation="GVVLAGGRGSRMGGIDKGLQLLKGKALWRHVADALQPQVTKLVIS
                     ANRNLDCWRSSGYPIITDSLNDFPGPLAGMLSVMHQVEGEWFLFCPCDTPFIPSFLATR
                     LIQQRKSSPAVWVHDGERDHPAIALVNREAIGELETYLAAGERRVMV"
     CDS             7633..8151
                     /locus_tag="ctg1_5343"
                     /transl_table=11
                     /translation="MIPLLAIAAWSGTGKTTLLKSLIPALRAEGLRPGLIKHTHHDMDV
                     DKPGKDSYELRKAGAAQTIVASSQRWALMTETPEEPPLDLEWLVSRMDASTLDLVLVEG
                     FKHEAVPKILLFRQNSGHSIEELVYDDDVIAIASDTPVETSLPLLDLNDVPQIAAFIMQ
                     WLKGFNEDR"
     PFAM_domain     7645..8049
                     /aSDomain="MobB"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03205.16"
                     /description="Molybdopterin guanine dinucleotide synthesis
                     protein B"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_5343_0216"
                     /evalue="3.80E-48"
                     /label="ctg1_5343"
                     /locus_tag="ctg1_5343"
                     /protein_end="139"
                     /protein_start="4"
                     /score="162.8"
                     /tool="antismash"
                     /translation="LAIAAWSGTGKTTLLKSLIPALRAEGLRPGLIKHTHHDMDVDKPG
                     KDSYELRKAGAAQTIVASSQRWALMTETPEEPPLDLEWLVSRMDASTLDLVLVEGFKHE
                     AVPKILLFRQNSGHSIEELVYDDDVIAIASD"
     aSDomain        7645..8124
                     /aSDomain="TIGR00176"
                     /aSTool="tigrfam"
                     /description="mobB: molybdopterin-guanine dinucleotide
                     biosynthesis protein B"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_5343_0048"
                     /evalue="6.10E-52"
                     /identifier="TIGR00176"
                     /label="ctg1_5343"
                     /locus_tag="ctg1_5343"
                     /protein_end="164"
                     /protein_start="4"
                     /score="173.7"
                     /tool="antismash"
                     /translation="LAIAAWSGTGKTTLLKSLIPALRAEGLRPGLIKHTHHDMDVDKPG
                     KDSYELRKAGAAQTIVASSQRWALMTETPEEPPLDLEWLVSRMDASTLDLVLVEGFKHE
                     AVPKILLFRQNSGHSIEELVYDDDVIAIASDTPVETSLPLLDLNDVPQIAAFIMQW"
ORIGIN
        1 tccagcgcgc tgaacacgct gactaaccag aaaagcctcg cgcgtacttc gaagacgcca
       61 ggccgtacgc agcttattaa cctgtttgaa gtcgctgaag gcaagcgcct ggtcgacctg
      121 ccgggctatg gatatgccca ggttccggaa gagatgaaaa tcaagtggca gcgcgcgctg
      181 ggtgaatatc tggagaaacg cctctgtctg aaaggactgg ttgtgttgat ggatattcgt
      241 catccgctta aagatctcga tcagcagatg atccaatggg cggtggaaag cgatatcccg
      301 gtactggtgc tgctaaccaa agccgataag ctggccagcg gcgcgcgaaa agcgcagatc
      361 gccatggttc gtgaagcggt caccgccttt aacggagatg tgcaggtcga agcgttttct
      421 tccctgaaga agcagggcgt ggataaacta cggcagaagc tggatagctg gtataacgat
      481 atccctcctc aggaagcctc tgaagaaggc gaataatctc gctaacttct ccggatagcg
      541 gcgcgtgtgg ctctatccgg gtagcccgcc tcatcagcat cgatacgcaa aaaattttct
      601 ttcgcgcaat aaaaaacgcc ccggtcataa atgaccgggg cggctaaaat attcagccaa
      661 atccgattac gtgaagtaaa aggtctgaaa gatagaacat cttacctctg taccctacgt
      721 ctttaactct actcttcttt cggttacgga taaagcattt tttgtagttt tttttcactc
      781 tttacatagc aaattcaaat gatcatcaca aaatgcgata agttatgtta ctcacttaca
      841 agaaatgacc ttccttaccg aatacttagt gcgcttgatc ccagttttct ccactaccca
      901 cttccaccag cagcggaacc gccagcgtcg tgctgctttc catcagttcg tggatctttt
      961 tcgcaaccgc ctcaaggtcg tctttatgca cttcaaagac cagttcatcg tgtacctgca
     1021 taatcatccg cacgcgcggt ttttcgctta ataaccagct atctacggcg atcatcgcgc
     1081 gcttaataat gtcggcagcg gttccctgca tcggcgcatt gatcgccgca cgctcggcac
     1141 cggcgcggcg cgcgccgttg ctggatttga tgtccggcag gtagagacga cggccatcaa
     1201 gcgtttcaac atacccctgc tctttggcct gggtgcgggt gcgctccata tactccagca
     1261 cgcccggata gcgctcaaag tagagatcca tatacttttg cgcttctttg cgtggaatat
     1321 tgagctggcg cgcaaggccg aatgcgctca tgccgtaaat caggccgaag ttgatcgcct
     1381 tcgcgctgcg gcgctgttcg ctgctgacgc tctccagcgg caaaccaaag acctctgccg
     1441 ccgtcgcgcg gtggatatcc ttcccttccg caaacgcggt cagcaggccc ttgtcgcggg
     1501 aaagatgcgc catgatgcgc agttcaattt gcgagtagtc ggcagagaca atgagataat
     1561 cttccggagc aataaacgcc tgacggatac gccgcccttc ttcgttgcgc accggaatgt
     1621 tctgcaggtt cgggtctgta gacgacaaac gtcccgttgc cgtaaccgcc tggtgataag
     1681 aggtgtgaac ccggcccgtt ttcgggctga tcatcagcgg cagcttatcg gtataggtgg
     1741 atttgagttt tgccagacca cgatactcga ggatgacttt cggcagcgga tagtccagcg
     1801 ccagctcttc cagcacctct tccgaggtag acggcgcgcc gcccggggtt ttcttcagcg
     1861 gcttaatacc ttgtttttca aacaggatgg tttgcagctg cttcggcgaa gagaggttaa
     1921 actcctcacc cgcgatatca tacgccttct tctccagctc aatcaggcgt ttggctatct
     1981 cctgagaatg cgcatgcagc acggccggat caatcttcac cccgttacgc tccacgcggg
     2041 atagcaccgg caccagcggc atttcaatat ttttaaagac gttcagcggg ccttcatttt
     2101 gctgaagttc aggccacatt ttgaggtgca gctgcagcgt gacatcggca tcttccgccg
     2161 cgtagcggcc cgcttcttcc agcgcgatct gattgaaggt gagctggttt ttacctttac
     2221 ccgctatctc ttcaaaggta atggttttgt gcttcagcca gcgatcggag aggctatcca
     2281 tatcatggcg gcccgccacg ctgtcaagaa tgtaggattc cagcatggta tcaaaggcaa
     2341 taccgcgcag ttcaatgccg tagttagcca ggataccgcg gtcatatttg aggttttgcc
     2401 caaccttcag aactttgtca tcttccagta gcggtttcag cagctcaagg acacggtcgc
     2461 gcgggatctg atccggtgca tccagataat catgggcaac cggtacatag gccgcaacgc
     2521 caggctcaat ggcgaaggat aagccaacca tattggcgga tacgttatcg aggctgtcag
     2581 tttcggtatc aaaggcaaaa agcggcgctt tcttcaggct ctcaacccag gtcaacaacg
     2641 tttcttcatc aaggatcgtg acataatttt cagaagagag cgccgtcgcg gtttcctcct
     2701 ccgcatcggc cacgtcagcc accgctacaa ccgccttcgc cgcaggctta gcgccttttg
     2761 cctgcatcca cttgccggac tctacatcgg tgatccagcg tttgaattca tattttttaa
     2821 acagcgtgag cagttcatca gcgacgggtt gcgcaaccag caaatcttca cagcccagct
     2881 ccagctcaac gtccgttttg atcgtcgcca gctgataaga gaggtacgcc acctctttat
     2941 tctgttccag ctttgcggcc atcgtttttg cgccgcggaa ggtcagccca gcgatttttt
     3001 caggctcagc gtataacgta tcaagaccac ccagcccctg cagtaacgcc tgcgctgtct
     3061 tttctcccac gccaggtacg cctggaatat tgtccgatga atctcccatc agggccagaa
     3121 aatcgatgat cagctccggt ggtacgccgt atttcgtcac cacttcatcg gggccaagga
     3181 tagtgttggt catggtgtta atcagcgtaa tacccggcgt aaccagctgg gccatatctt
     3241 tatcgccggt gctaatcagt accggacgcc cgaccttttc agcttcacgc gccagggtac
     3301 cgatgacatc atcggcttct acgccaggaa cagccattag cggcaggccc atcgctttta
     3361 ccatggcatg cagcggctcg atctgcgcac gcagatcgtc cggcatcggc gggcgatgag
     3421 atttatagtg ctcaaacagt tcatcacgga aagtcttccc cttggcatca aacacgacga
     3481 cagcgtgggt cggttgatac tgcaggatca ggcttcgcag catattcagc acgccataca
     3541 ttgcgcctgt cggttcacca gcgctattcg tcagcggggg gaacgcgtga tatgcccgat
     3601 aaaggtaaga ggagccgtca acgaggatga gaggtttttc tgggatctga accataattt
     3661 ccgtgcctgt ttatcagatt atcggtaaag gatgccacag acgggcatta aatcctgaat
     3721 ttttcccgca tttcgtcgaa aagattctgc gatcctttcg atcgcgttat gggctatcct
     3781 gtggataact ttgtgaatat ttttataacg acagccaaac aatcgttaat taaatcatcc
     3841 ataaacaaat tatttcatat ttatcattaa gttatacacg cataatttgc tttaataaca
     3901 ccatggcgac tcaatgttcc atgtggatat aagatccgaa aatttttctg ttctggtaag
     3961 acccgttatt tacgctattt tctggtaaaa tcagcctctt gcgccgttta aacgcgttct
     4021 ttgtcaatct aactttctga ataaattaac tatgtcgaga ttactcgccg cgataacgct
     4081 cccgctgagt atcgccctga ctatcatagt caccataatc tgctcggtgc caatcatcgt
     4141 cgccgggctg attaaacttc ttgtgcctat tcctgcggtc tggcgctcga tatccgtttt
     4201 ttgcaatttc atgatgtact gctggtgtga agggctggct ctgctgctgc ctcttaatcc
     4261 ctggcttaaa tgggatatac agggcctgga tggcctgaat aagaaaaact ggtatctgct
     4321 catcagcaac caccatagct gggcagatat cgtggtgctt tgcgtgctgt ttcgcaaaca
     4381 tatcccgatg aataaatatt tcctcaagca acagctcgcc tgggtgccgt ttattgggct
     4441 ggcctgctgg gcgctggata tgccttttat gcgccgctat tcccgaggct acttactccg
     4501 ccatccagaa cgccggggca aagatgttga aaccactcgc cgctcctgcg agaaattccg
     4561 cgcgcatcca acaacgattg ttaactttgt cgaaggctct cgtttcacgg aagaaaagca
     4621 acagcaggcc cgttcgcctt accagaatct gttatcgcca aaggctgcgg gtattgccat
     4681 ggcattaagc gtgctcggct cgcagtttga taagcttttg aacgtcacgt tatgctatcc
     4741 ggaaaacaac caaaagccgt tttatgacat gctgagcggc cgattgacgc ggattgtggt
     4801 gagagtcagt cttgaacctg tgacggaaga gctgcacggc gattatgtaa atgacaaaaa
     4861 ctttaagcga cgctttcagc gctggctaaa caggctttgg gaagagaaag atcggcagct
     4921 aacggaaata atgcagcagg cagagaaata attgtgggcg cagaaaagaa aaacgccggt
     4981 cagtaaccgg cgtttatttt ttatttcttc tcaacgagct gcttaacggc atcggcatac
     5041 tgggcaacaa atgcgtccat gttgctggta tccataccct gcgggttaag ctggtattta
     5101 ccgttaacgt acatagccgg cacgccctgc agctggaaat cagcggcggc tttctcttgc
     5161 tgagccacca gggatttcac cacgaagctg ttccaggctg catcgtaatc ttcaccttta
     5221 acgccggcgt caacgaagac cttacggatg tcggccacgg tctggacggt ctggtttttc
     5281 tgtaccgctt caaacatcgg cacggtaatt ttatcttcca cacccagcgc catcgcaacg
     5341 gcccacgcct gagtcagatc cttgcctaac ggacccagga actcaacgtg gtatttcgtc
     5401 attttgacgc cttcaggcag ctttttcttc acgttatctg atacatgaag aacttcctca
     5461 aactgatagc aatgcgggca gtagaacgag aaaaactcga gcacctgcgg ctcaccggca
     5521 acgggcttat cgagggtaat atactgctta ccgtcggtga tctgggcagc ggatgcactg
     5581 aaagccagaa tcataccagc cagcgccagc caaatttttt tcatgattaa ttctctcctg
     5641 gatatatcac attaatacat tggcgttaac tgaagaggcg gttcctgcag aacctttacc
     5701 tgctcaagaa aagttgttgt ctgcccgcgc cagtaatctt ccccggttaa ccacgggaag
     5761 tttttaggaa aagcgggatc ttcccagcgc cttaataacc acgccagata ataaactaac
     5821 cgcattgcac gtaaaggttc gatgagggca atttcatcgg tattgaaagc gctgaactct
     5881 tcatacgctt caatgatcat ctcaagctgc atccgttgtt cggctttatc gccgttcaac
     5941 aacatccaca gatcctggat agcaggtcca ttacgtgaat catctaaatc aacaaacagt
     6001 ggcccatcgc gccagaggat gtttcccgca tggcaatcac cgtgtaaccg taaaatattg
     6061 gcgcgtccgt gccattgcgc cattaccgca tcaatcagct tatcggtagc gctgagaaaa
     6121 gcctctttca gacctgcagg tatcagcggg gaaagctcaa agacctggcg tggctcaaga
     6181 agatactcat tcgtccctat ctccggacgc gcgacaaaac gctgtttgcg tccagtttga
     6241 tgcagacggc caaggtagcg cccaacccat tccatctgat cgaggttatc cgcctcaaac
     6301 tgacgtccac ccaggcttgg gaatacggcg aaaaagaatc cctgatgctg atgaagggta
     6361 ctgttgttaa acgacaacgg cgccgctaca gggacttcgt cctgcacgag ctggagggaa
     6421 aactgatgtt cttcgaggat ctgctgggcg gaccagcgct caggacgata gaacttcacc
     6481 acatagcggc gacgatcttc gtcctgaaac tggtaaaccc ggttctcata gctattaagc
     6541 ggagtgagac cggagtccac ccgcattccc agatcaaata agccatcaat gatggtatcc
     6601 gggtgaagcg tctgaaaagt gaaagcctta tcgtgcatcc tgacatccga taatcgtacg
     6661 aatgatacag gatatcatct cattgccgat tccgcggcag cgcttacaac cttttactct
     6721 ttaatcacgc cgcgagcgcg tagcagcgcg gttttaaaat cttcttcata atctttctga
     6781 atcccgggaa taacggcttc ttttgccgag tcgcgcatct tcagatgata aatcagaata
     6841 tcgtcggaga gatcgttcaa ctcaccggtg tatccggcct ctttcgccag tttttgcaaa
     6901 aattgcatta aattcagctc gggttctttc tgccaggctg gctggaggag ttcaatgact
     6961 tcattcagac gtttacattt catagcaatg ctccttactc ttgataggaa tacgttagca
     7021 gggacaatcc cacaatgaaa gaggcgatat taatatgcag ggcaaggtca taaccggcgt
     7081 cgtgctggcg ggaggaagag gctcgcgcat gggaggaata gataaaggat tacagctgct
     7141 gaaaggtaaa gccctgtggc gtcatgtcgc cgatgcgctg cagccgcagg ttacaaagct
     7201 ggtaattagc gctaaccgca atcttgattg ctggcgaagc agcggctacc cgattattac
     7261 cgactctctg aacgactttc ccgggccgtt ggccggcatg ctttccgtaa tgcatcaggt
     7321 tgagggcgag tggtttctgt tttgtccctg tgatacgcca tttatcccat catttctggc
     7381 gacgcgctta atacagcaga gaaaatcctc tccagccgtt tgggtacacg atggtgaacg
     7441 tgaccatccg gccattgctc tggtgaatcg cgaggcgatc ggcgaactgg aaacgtatct
     7501 ggccgcagga gaaagacggg taatggtatt tctgcgcaaa attggcggtc atagcgtcga
     7561 ttttagcgat gtaaaatcag catttattaa cgtcaatact ctcgacgatt tgcaacgtat
     7621 gcaggtgcca tcatgattcc gcttttagcc atcgcagcct ggagcggtac aggtaaaacc
     7681 accctactga agtcgctgat tccggcactg cgcgcggaag gcttacggcc agggctaatt
     7741 aaacatactc atcacgatat ggacgtggat aaacccggta aagacagcta tgaactgcgt
     7801 aaagccggag cggctcagac gattgtcgcc agctcccagc gttgggcatt aatgacggaa
     7861 acacccgaag agcctccgct ggatctggaa tggctggtta gccgaatgga tgcatcaacg
     7921 ttagatttag tcctggttga gggttttaag catgaagctg tgcccaaaat cctgcttttt
     7981 cggcaaaaca gcgggcatag tattgaagaa ttagtttatg acgatgacgt gattgccata
     8041 gccagcgata cgccggtcga gacatcgctt ccactgttag atttaaatga tgtcccgcaa
     8101 atagccgctt ttattatgca gtggttaaag gggtttaacg aggaccgata gttattgcag
     8161 agatatagcc atgatcgcgc cttctgaagg catctgctga tagtttcaga cgacaaaaac
     8221 gcaaaaagcc catccgtcag gatgggctct tcacttgttt gatgcctggc agttccctac
     8281 tctcacatgg ggagacccca cactaccatc ggcgctacgg cgtttcactt ctgagttcgg
     8341 catggggtca ggtgggacca ccgcgctagt gccgccaggc aaattctgtt gtcagaaacg
     8401 aatcttttat ctttcgttcc cgaaaatctg taatctaagc tgaaattgtt gtcttctcaa
     8461 atccgccaaa acatcttcgg cgttgtaagg ttaagcctca cggttcatta gtaccggtta
     8521 gctcaacgca tcgctgcgct tacacacccg gcctatcaac gtcgtcgtct tcaacgttcc
     8581 ttcaggactc tcaaggagtc agggagaact catctcgggg caagtttcgt gcttagatgc
     8641 tttcagcact tatctcttcc gcatttagct accgggcaat gccattggca tgacaacccg
     8701 aacaccagtg atgcgtccac tccggtcctc tcgtactagg agcagccccc ctcaattctc
     8761 cagcgcccac ggcagatagg gaccgaactg tctcacgacg ttctaaaccc agctcgcgta
     8821 ccactttaaa tggcgaacag ccataccctt gggacctact tcagccccag gatgtgatga
     8881 gccgacatcg aggtgccaaa caccgccgtc gatatgaact cttgggcggt atcagcctgt
     8941 tatccccgga gtacctttta tccgttgagc gatggccctt ccattcagaa ccaccggatc
     9001 actatgacct gctttcgcac ctgctcgcgc cgtcacgctc gcagtcaagc cagcttatgc
     9061 cattgcacta acctcctgat gtccgaccag gattagctga ccttcgtgct cctccgttac
     9121 tctttaggag gagaccgccc cagtcaaact acccaccaga cactgtccgc aaccccgatt
     9181 aggggcccac gttagaacac cagccattaa agggtggtat ttcaaggatg gctccatgca
     9241 gactggcgtc cacacttcaa agcctcccac ctatcctaca catcaaggac cagtgttcag
     9301 tgtcaagcta tagtaaaggt tcacggggtc tttccgtctt gccgcgggta cactgcatct
     9361 tcacagcgag ttcaatttca ctgagtctcg ggtggagaca gcctggccat cattacgcca
     9421 ttcgtgcagg tcggaactta cccgacaagg aatttcgcta ccttaggacc gttatagtta
     9481 cggccgccgt ttaccggggc ttcgatcaag agcttctcct tacggataac cccatcaatt
     9541 aaccttccgg caccgggcag gcgtcacacc gtatacgtcc actttcgtgt ttgcacagtg
     9601 ctgtgttttt aataaacagt tgcagccagc tggtatcttc gactgatttc agctccacga
     9661 gcaagtcgct tcacctacca tcagcgtgcc ttctcccgaa gttacggcac cattttgcct
     9721 agttccttca cccgagttct ctcaagcgcc ttggtattct ctacctgacc acctgtgtcg
     9781 gtttggggta cgatttgatg ttacctgatg cttagaggct tttcctggaa gcagggcatt
     9841 tgtcacttca gcaccgtagt gcctcgtcat cacacctcag cgttaataac gttccggatt
     9901 tacctggaac atccgcctac atgcttaaac cgggacaacc gtcgcccggc caacatagcc
     9961 ttctccgtcc ccccttcgca gtaacaccga gtacaggaat attaacctgt ttcccatcga
    10021 ctacgccttt cggcctcgcc ttaggggtcg actcaccctg ccccgattaa cgttggacag
    10081 gaacccttgg tcttccggcg tgcgggtttt tcacccgcat tatcgttact tatgtcagca
    10141 ttcgcacttc tgatacctcc agcaaccctc acaggccacc ttcaacggct tacagaacgc
    10201 tcccctaccc aacaacacat agtgtcgctg ccgcagcttc ggtgcatggt ttagccccgt
    10261 tacatcttcc gcgcaggccg actcgaccag tgagctatta cgctttcttt aaatgatggc
    10321 tgcttctaag ccaacatcct ggctgtctgg gccttcccac atcgtttccc acttaaccat
    10381 gactttggga ccttagctgg cggtctgggt tgtttccctc ttcacgacgg acgttagcac
    10441 ccgccgtgtg tctcccgtga taacattctt cggtattcgt agtttgcatc gggttggtaa
    10501 gtcgggatga ccccctagcc gaaacagtgc tctacccccg aagatgagtt cacgaggcgc
    10561 tacctaaata gctttcgggg agaaccagct atctcccggt ttgattggcc tttcaccccc
    10621 agcc
//
