LOCUS       NZ_AP022547.1          10786 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_AP022547.1 Klebsiella michiganensis strain THO-011 chromosome,
            complete genome.
ACCESSION   NZ_AP022547
VERSION     NZ_AP022547.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 13:04:02
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 920344
            Orig. end    :: 931130
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10786
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[925344:926130](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5786)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     cand_cluster    1..10786
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10786
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="2"
                     /rules="AfsA"
                     /tool="antismash"
     CDS             complement(482..1657)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124:acetyl-CoA acetyltransferase (Score: 484.6;
                     E-value: 3e-147)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_870"
                     /transl_table=11
                     /translation="MNEVVIVSAKRTATGAFMGSLSGHSAAELGSHVIRALLEDSGVEA
                     SEISQVIMGQVLTAGCGQNPARQSALNAGLPVETQCLTINKVCGSGLKSVHLAMLALQT
                     GEAEFVIAGGQESMSNAPHILMASRSGTRLGDCNMRDSVVSDGLWDAFDNNHMGVTAEN
                     VAAEFSISREMQDEYALLSHIKAMDAQEKGIFAREIVPVEWQDRKGKTLRVDTDEGPRK
                     TSIEKLMQLKPVFRKGGTVTAGNASSLNDGAAAVLLCTRKTAEARGLLVLASLAAFANS
                     GIKPALMGAAPVQAIADCLSRSGWKPEDVDHLESNEAFAAQALAVVDQTGISPDRINPY
                     GGGIALGHAIGASGCRILVTLVHGLLRNDNKRGVAALCVGGGEGVALSVYR"
     PFAM_domain     complement(491..847)
                     /aSDomain="Thiolase_C"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02803.20"
                     /description="Thiolase, C-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_870_0057"
                     /evalue="8.20E-40"
                     /label="ctg1_870"
                     /locus_tag="ctg1_870"
                     /protein_end="389"
                     /protein_start="270"
                     /score="135.4"
                     /tool="antismash"
                     /translation="VLASLAAFANSGIKPALMGAAPVQAIADCLSRSGWKPEDVDHLES
                     NEAFAAQALAVVDQTGISPDRINPYGGGIALGHAIGASGCRILVTLVHGLLRNDNKRGV
                     AALCVGGGEGVALSV"
     aSDomain        complement(494..1642)
                     /aSDomain="TIGR01930"
                     /aSTool="tigrfam"
                     /description="AcCoA-C-Actrans: acetyl-CoA
                     C-acyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_870_0012"
                     /evalue="1.00E-127"
                     /identifier="TIGR01930"
                     /label="ctg1_870"
                     /locus_tag="ctg1_870"
                     /protein_end="388"
                     /protein_start="5"
                     /score="424.2"
                     /tool="antismash"
                     /translation="IVSAKRTATGAFMGSLSGHSAAELGSHVIRALLEDSGVEASEISQ
                     VIMGQVLTAGCGQNPARQSALNAGLPVETQCLTINKVCGSGLKSVHLAMLALQTGEAEF
                     VIAGGQESMSNAPHILMASRSGTRLGDCNMRDSVVSDGLWDAFDNNHMGVTAENVAAEF
                     SISREMQDEYALLSHIKAMDAQEKGIFAREIVPVEWQDRKGKTLRVDTDEGPRKTSIEK
                     LMQLKPVFRKGGTVTAGNASSLNDGAAAVLLCTRKTAEARGLLVLASLAAFANSGIKPA
                     LMGAAPVQAIADCLSRSGWKPEDVDHLESNEAFAAQALAVVDQTGISPDRINPYGGGIA
                     LGHAIGASGCRILVTLVHGLLRNDNKRGVAALCVGGGEGVALS"
     PFAM_domain     complement(875..1648)
                     /aSDomain="Thiolase_N"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00108.25"
                     /description="Thiolase, N-terminal domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_870_0056"
                     /evalue="1.30E-98"
                     /label="ctg1_870"
                     /locus_tag="ctg1_870"
                     /protein_end="261"
                     /protein_start="3"
                     /score="329.6"
                     /tool="antismash"
                     /translation="VVIVSAKRTATGAFMGSLSGHSAAELGSHVIRALLEDSGVEASEI
                     SQVIMGQVLTAGCGQNPARQSALNAGLPVETQCLTINKVCGSGLKSVHLAMLALQTGEA
                     EFVIAGGQESMSNAPHILMASRSGTRLGDCNMRDSVVSDGLWDAFDNNHMGVTAENVAA
                     EFSISREMQDEYALLSHIKAMDAQEKGIFAREIVPVEWQDRKGKTLRVDTDEGPRKTSI
                     EKLMQLKPVFRKGGTVTAGNASSLNDGAAAVLLCTR"
     CDS             complement(1654..2067)
                     /locus_tag="ctg1_871"
                     /transl_table=11
                     /translation="MSPTDELTRYGRDIMDRLESGLADKVTTRLSELDSTLPALITDYA
                     FGAVVGRPGLDLRTREMLTVASLVTLGNAMPQLELHMRAALNTGVTPEELLEIVIQMAI
                     YAGVPACMNGLTAYRAAMAATGHTLPGLKEEMS"
     PFAM_domain     complement(1717..1956)
                     /aSDomain="CMD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02627.22"
                     /description="Carboxymuconolactone decarboxylase family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_871_0058"
                     /evalue="1.50E-18"
                     /label="ctg1_871"
                     /locus_tag="ctg1_871"
                     /protein_end="117"
                     /protein_start="37"
                     /score="66.7"
                     /tool="antismash"
                     /translation="PALITDYAFGAVVGRPGLDLRTREMLTVASLVTLGNAMPQLELHM
                     RAALNTGVTPEELLEIVIQMAIYAGVPACMNGLTA"
     CDS             complement(2054..3274)
                     /gene_functions="transport (smcogs) SMCOG1184:major
                     facilitator transporter (Score: 286.2; E-value: 5.1e-87)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_872"
                     /transl_table=11
                     /translation="MHSEKSPQDMTFRSWLALFILALSTFTIVTTELAPVGLLTPIAEG
                     LGASESAVGMTVSLYAWVGALSALFASVFLGNVAKKRLLLTLTVILFLSNVLAATVNTY
                     AILLVARVLGALAHGSFWAMIGATAVAIVPARFLGAATSIVFGGVSAASVFGVPISNYI
                     GIHFGWRQAFWLMALLSVVAFAGITILVPQITSKSAIGLGALKSVFKSSALWKIYSATL
                     LAVTAHFAAFTYIEPWLHTQHSLATSVIPAVLFVYGIAGLAGNFLTGMVIDKHLKATVS
                     VSVVLICAVLVFLGLSGTSLSGTAVFTAMVIWGVAVSGIFVGFQTWVLRLAEDKAFPAS
                     AVYVSFFNTAIGVGASAGAWMVSAFSVPLLYIAAGAAIGLSVLLVAAIPTRLRSEQTTP
                     EKYYEPN"
     PFAM_domain     complement(2279..3229)
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_872_0059"
                     /evalue="9.50E-30"
                     /label="ctg1_872"
                     /locus_tag="ctg1_872"
                     /protein_end="332"
                     /protein_start="15"
                     /score="103.8"
                     /tool="antismash"
                     /translation="LALFILALSTFTIVTTELAPVGLLTPIAEGLGASESAVGMTVSLY
                     AWVGALSALFASVFLGNVAKKRLLLTLTVILFLSNVLAATVNTYAILLVARVLGALAHG
                     SFWAMIGATAVAIVPARFLGAATSIVFGGVSAASVFGVPISNYIGIHFGWRQAFWLMAL
                     LSVVAFAGITILVPQITSKSAIGLGALKSVFKSSALWKIYSATLLAVTAHFAAFTYIEP
                     WLHTQHSLATSVIPAVLFVYGIAGLAGNFLTGMVIDKHLKATVSVSVVLICAVLVFLGL
                     SGTSLSGTAVFTAMVIWGVAVSGIFVGFQTWVLRLA"
     CDS             complement(3297..3947)
                     /locus_tag="ctg1_873"
                     /transl_table=11
                     /translation="LQQAAAFFDVDETLINIKSMFDFFNFWCKENNEHIKLHNYMANFQ
                     SEVKKGTPREHLNREYYRQFAGISYKALEEAGERWFRFKLNSELFIGSAVSALKKHQAE
                     NMDIVFISGSMLPVLSPVARYLGVQDILCAPLKFTAAGEMTGEIGYPQTIGDGKKDALL
                     QFCEQRNINPSDCYAYGDDLSDIPMLASTGHPVCVGKHSALARHAITHRWQVI"
     aSDomain        complement(3348..3935)
                     /aSDomain="TIGR01490"
                     /aSTool="tigrfam"
                     /description="HAD-SF-IB-hyp1: HAD hydrolase, family IB"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_873_0013"
                     /evalue="2.40E-37"
                     /identifier="TIGR01490"
                     /label="ctg1_873"
                     /locus_tag="ctg1_873"
                     /protein_end="200"
                     /protein_start="4"
                     /score="127.1"
                     /tool="antismash"
                     /translation="AAFFDVDETLINIKSMFDFFNFWCKENNEHIKLHNYMANFQSEVK
                     KGTPREHLNREYYRQFAGISYKALEEAGERWFRFKLNSELFIGSAVSALKKHQAENMDI
                     VFISGSMLPVLSPVARYLGVQDILCAPLKFTAAGEMTGEIGYPQTIGDGKKDALLQFCE
                     QRNINPSDCYAYGDDLSDIPMLASTGHPVCVGK"
     aSDomain        complement(3378..3935)
                     /aSDomain="TIGR01488"
                     /aSTool="tigrfam"
                     /description="HAD-SF-IB: HAD phosphoserine phosphatase-like
                     hydrolase, family IB"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg1_873_0014"
                     /evalue="1.90E-24"
                     /identifier="TIGR01488"
                     /label="ctg1_873"
                     /locus_tag="ctg1_873"
                     /protein_end="190"
                     /protein_start="4"
                     /score="84.5"
                     /tool="antismash"
                     /translation="AAFFDVDETLINIKSMFDFFNFWCKENNEHIKLHNYMANFQSEVK
                     KGTPREHLNREYYRQFAGISYKALEEAGERWFRFKLNSELFIGSAVSALKKHQAENMDI
                     VFISGSMLPVLSPVARYLGVQDILCAPLKFTAAGEMTGEIGYPQTIGDGKKDALLQFCE
                     QRNINPSDCYAYGDDLSDIPMLA"
     PFAM_domain     complement(3381..3932)
                     /aSDomain="HAD"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF12710.9"
                     /description="haloacid dehalogenase-like hydrolase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_873_0060"
                     /evalue="3.20E-23"
                     /label="ctg1_873"
                     /locus_tag="ctg1_873"
                     /protein_end="189"
                     /protein_start="5"
                     /score="83.3"
                     /tool="antismash"
                     /translation="AFFDVDETLINIKSMFDFFNFWCKENNEHIKLHNYMANFQSEVKK
                     GTPREHLNREYYRQFAGISYKALEEAGERWFRFKLNSELFIGSAVSALKKHQAENMDIV
                     FISGSMLPVLSPVARYLGVQDILCAPLKFTAAGEMTGEIGYPQTIGDGKKDALLQFCEQ
                     RNINPSDCYAYGDDLSDIPML"
     CDS             complement(3951..4175)
                     /locus_tag="ctg1_874"
                     /transl_table=11
                     /translation="MPFVHITTWPVKDEGKIIRLQEDITFAVHKHTGAPLDKISVVISE
                     IHPSRWADAGVPGNHKDFQEKSRRKNYEE"
     PFAM_domain     complement(4008..4172)
                     /aSDomain="Tautomerase"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF01361.23"
                     /description="Tautomerase enzyme"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_874_0061"
                     /evalue="2.40E-06"
                     /label="ctg1_874"
                     /locus_tag="ctg1_874"
                     /protein_end="56"
                     /protein_start="1"
                     /score="27.4"
                     /tool="antismash"
                     /translation="PFVHITTWPVKDEGKIIRLQEDITFAVHKHTGAPLDKISVVISEI
                     HPSRWADAGV"
     CDS             complement(4184..4942)
                     /locus_tag="ctg1_875"
                     /transl_table=11
                     /translation="MDGNGNFVVVGMVPGDNGLEWRSVLVAADSPVPEFGATKPYRILR
                     DIEGMSQDEVKDIILHTLPLPIPSNNYGMLFAPEQRPQANTESRPSLPLHEGYIADYRS
                     SDGKRQVQPVTLENWMHAEGTLDVCLSEDSRRARFTFSFRNLVPDSVYTVMSLREKDLA
                     TENPSRPGPLGIPNVFITDHNGNADYWAELPDPFPAHERNENRIINVVVLYMSSRQSYG
                     GAIGLYGLGGDIHAHLKLKVRSFDEFTTVE"
     CDS             complement(5001..5786)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_876"
                     /sec_met_domain="AfsA (E-value: 9.6e-10, bitscore: 36.7,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYKKLVIVGDKFNEFANGKDVLTISQLELLSQIPANIIDKEHEI
                     IIGQGVRKDFAGKVISNQARNVVHGNKLKMCSLEKLVRDKKNAHCHKRLEQNVLIGSAE
                     QTEHNSDLFAMPLLIDERCELMADHQTGQHIQGMLLVEASRQAFIAVTEEFIYKQEAGR
                     YYVINSMATTFSSFLFPLPALVHFEFLEKDINERRGRFRAQVRVTQHQTLCATMDVSFT
                     VYPSALIAEKEKLLAEAAMQAAIAEQNIATHGVTHVQIS"
     PFAM_domain     complement(5121..5516)
                     /aSDomain="AfsA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03756.15"
                     /description="A-factor biosynthesis hotdog domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_876_0062"
                     /evalue="2.10E-14"
                     /label="ctg1_876"
                     /locus_tag="ctg1_876"
                     /protein_end="222"
                     /protein_start="90"
                     /score="53.7"
                     /tool="antismash"
                     /translation="HKRLEQNVLIGSAEQTEHNSDLFAMPLLIDERCELMADHQTGQHI
                     QGMLLVEASRQAFIAVTEEFIYKQEAGRYYVINSMATTFSSFLFPLPALVHFEFLEKDI
                     NERRGRFRAQVRVTQHQTLCATMDVSFT"
     CDS             complement(5797..6408)
                     /locus_tag="ctg1_877"
                     /transl_table=11
                     /translation="MSANYVLVSRFPLKNNVSAADFSFLKNSGSTRYYYSEEQGVNELL
                     ELRAFNDIKEISWVEEEMVSMFHRLADVLSADIRRELLKFVESPIDNKKDLPESQYIQL
                     RHVEVPAHNYQQYRQWRDETIFNVVRDNKDKIESFEAFHSLISGVPGVMFISSFNGDKQ
                     SYKEAFTNARYQEIIQQAGDNYITGGNEGLYTRIYHACCS"
     CDS             6601..7527
                     /gene_functions="regulatory (smcogs) SMCOG1014:LysR family
                     transcriptional regulator (Score: 141.6; E-value: 4.9e-43)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_878"
                     /transl_table=11
                     /translation="MAIAGHLISNHLPSVKQLQCFLAVAHELNFRRAAERLRMTQPPLT
                     RHIKCLEGVLNQQLFSRSTHDVSLTEAGQALVIRAEKILLELNELKTGSLASGGKVRIG
                     LTRTLNFEFIEPVSRQLIELDAGDDVETPNLTSAQLLQCLSKNTLDLVLTGEKGTGHED
                     MVQYRWVCCEPLLIAMPAIHPASLKEKVSLKDVSDLPLFWFSRSANPSFYDKCESFFEQ
                     LNVPLKRVKEPDDSLVMLTRIARGKGFALMPQSKCTFNQEGLCYRELTDDESQKLNIDI
                     YSAIRVNETREAVLDAQNVLCGKNFSG"
     PFAM_domain     6646..6822
                     /aSDomain="HTH_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00126.29"
                     /description="Bacterial regulatory helix-turn-helix
                     protein, lysR family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_878_0063"
                     /evalue="2.50E-18"
                     /label="ctg1_878"
                     /locus_tag="ctg1_878"
                     /protein_end="74"
                     /protein_start="15"
                     /score="65.9"
                     /tool="antismash"
                     /translation="KQLQCFLAVAHELNFRRAAERLRMTQPPLTRHIKCLEGVLNQQLF
                     SRSTHDVSLTEAGQ"
     PFAM_domain     6892..7419
                     /aSDomain="LysR_substrate"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03466.22"
                     /description="LysR substrate binding domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_878_0064"
                     /evalue="2.50E-14"
                     /label="ctg1_878"
                     /locus_tag="ctg1_878"
                     /protein_end="273"
                     /protein_start="97"
                     /score="53.3"
                     /tool="antismash"
                     /translation="GGKVRIGLTRTLNFEFIEPVSRQLIELDAGDDVETPNLTSAQLLQ
                     CLSKNTLDLVLTGEKGTGHEDMVQYRWVCCEPLLIAMPAIHPASLKEKVSLKDVSDLPL
                     FWFSRSANPSFYDKCESFFEQLNVPLKRVKEPDDSLVMLTRIARGKGFALMPQSKCTFN
                     QEGLCYRELTDDE"
     CDS             7805..7942
                     /locus_tag="ctg1_879"
                     /transl_table=11
                     /translation="MTIICRRFLMPLMQFQPVLNINNAWLNKNPGQVSWKITNNHRQRQ
                     "
     CDS             7969..8499
                     /locus_tag="ctg1_880"
                     /transl_table=11
                     /translation="MLLIFGGLPGTGKSTIARLLAARLGAVWLRIDSIEQALIRAETVT
                     RHDIGPAGYLVAYAIAADNLRQGNVVIADSVNPIAITRQAWRAVATENAAPYLEIELTC
                     SDQMQHRYRVENRVADIRGHILPDWQKVIAREYEPWRTASLTLDTSVLTAEEAVERIVE
                     HIALRGRHAPVGS"
     PFAM_domain     7972..8322
                     /aSDomain="AAA_33"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF13671.8"
                     /description="AAA domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_880_0065"
                     /evalue="8.30E-11"
                     /label="ctg1_880"
                     /locus_tag="ctg1_880"
                     /protein_end="118"
                     /protein_start="1"
                     /score="42.3"
                     /tool="antismash"
                     /translation="LLIFGGLPGTGKSTIARLLAARLGAVWLRIDSIEQALIRAETVTR
                     HDIGPAGYLVAYAIAADNLRQGNVVIADSVNPIAITRQAWRAVATENAAPYLEIELTCS
                     DQMQHRYRVENRV"
     CDS             complement(8527..10176)
                     /gene_functions="transport (smcogs) SMCOG1137:Major
                     facilitator superfamily MFS 1 (Score: 168; E-value:
                     4.5e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_881"
                     /transl_table=11
                     /translation="MAQMNENIATAPVSPLRDFFAKPRIIARPGFNRWLVPPAALAVHL
                     CIGMAYGFSVYWLPMSQLIGGSASLQCPVTMSFWQQLFTRDCDWKISMLGWTYTLFFVF
                     LGCSAALWGSWLEKVGPRLVSFIATLCWCGGLLLSSVAIYFHQLWLLWLGAGVIGGIGL
                     GLGYISPVSTLLRWFPDKRGMAAGMAIMGFGGGALVGAPLANGLMNYFAGPAGNGVWQS
                     ILALAAIYALFMLAGTFGYRLPPMGWHPSGEKAQKTIRNNPTIQVHVRVACRTPQFWLL
                     WMVLWLNVTAGIGILGMASPMLQEIFAGKLLSLDLSWHELNGEQLKRIATMAAGFTGLL
                     SLFNILGRFFWASVSDLCGRKMTFAIIFCLGAVLYGTLPLVNHGGYIALYVCAMCIIIS
                     MYGGGFASIPAYLADVFGSQMVGAIHGRLLTAWSAAGISGPVLVNYLREYQLTHGVSPE
                     RVYDITLMVLTGLLVLGFICNQLVRPLTEEHAMTAEQQQQAKGLYTINKDAQLTWEPRP
                     STLLLTISWLAVSVPLLWGVGTTLQQAVKFFM"
     PFAM_domain     complement(8857..9954)
                     /aSDomain="MFS_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07690.18"
                     /description="Major Facilitator Superfamily"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg1_881_0066"
                     /evalue="3.30E-36"
                     /label="ctg1_881"
                     /locus_tag="ctg1_881"
                     /protein_end="440"
                     /protein_start="74"
                     /score="125.0"
                     /tool="antismash"
                     /translation="TMSFWQQLFTRDCDWKISMLGWTYTLFFVFLGCSAALWGSWLEKV
                     GPRLVSFIATLCWCGGLLLSSVAIYFHQLWLLWLGAGVIGGIGLGLGYISPVSTLLRWF
                     PDKRGMAAGMAIMGFGGGALVGAPLANGLMNYFAGPAGNGVWQSILALAAIYALFMLAG
                     TFGYRLPPMGWHPSGEKAQKTIRNNPTIQVHVRVACRTPQFWLLWMVLWLNVTAGIGIL
                     GMASPMLQEIFAGKLLSLDLSWHELNGEQLKRIATMAAGFTGLLSLFNILGRFFWASVS
                     DLCGRKMTFAIIFCLGAVLYGTLPLVNHGGYIALYVCAMCIIISMYGGGFASIPAYLAD
                     VFGSQMVGAIHGRLLTAWSAAGISGP"
ORIGIN
        1 ctggtaccct attctccgct gggaaggggg ttcctgacag gaaaataccg taaaaacagt
       61 gatttttctg aaggtgactt ccgtaaaaat aatgagcgtt tcattcagtc cagccttgat
      121 cacaacgtac agcttctcga tgctgttctc ccgcttactg aaaagtacgg ttgttcctcg
      181 ggtcaggtgg cgctggcctg gctgctcgcg cagtacgata agctggtacc gatccccggt
      241 accaagcaca tcagttatct ggccgaaaat gcgcaggcgg ctgacatcgc tctggacaaa
      301 tcagatgttg cgctactgaa cgatattcac cagcgcgttg agattaaagg cggccggtat
      361 tctgaagaag gtatgaaagg cgttaacgcc tgaaatccgt ttacataata tgaaaccggg
      421 cattgcccgg ttattttgtt tttattaaca gcccagccgc tgtacagccg ataatttttc
      481 ttcagcggta aacgctcagc gccacccctt caccgccgcc aacacacagc gctgcaacac
      541 cgcgtttatt atcattacgc aggagtccat gcacgagggt gaccagaatg cggcatcccg
      601 aggcaccgat agcatgcccg agtgcgattc ctccgccata gggattaata cgatcgggtg
      661 aaatacccgt ctggtcaacc actgccagcg cctgggctgc aaacgcttca ttggactcca
      721 ggtgatcaac atcttctggt ttccagccag agcgggaaag acagtctgcg atagcctgta
      781 ccggagcggc acccattaat gccggcttaa tccccgaatt cgcaaacgcg gcaagagacg
      841 ctaaaaccag cagcccacgt gcctcggcag tttttctggt acaaagaagg acagcggccg
      901 cgccatcatt aagagaggat gcattacctg ccgtcacagt tcctcccttt ctgaaaacgg
      961 gtttcagctg cattagtttt tcaatgctgg ttttgcgggg gccttcatcc gtgtcaactc
     1021 tcagggtttt acctttcctg tcctgccatt caacgggaac tatttcacga gcaaatattc
     1081 ccttttcctg agcatccatt gcctttatgt gggacagtag cgcgtattca tcttgcattt
     1141 cgcgactgat gctgaactca gctgcaacat tttcggcggt gacgcccata tggttattat
     1201 cgaaagcatc ccagagtcca tcggacacca cgctatccct catattacaa tcccccagcc
     1261 ttgtccctga gcgtgaagcc atcagaatat gaggggcgtt agacatgctc tcctgaccgc
     1321 cggcaatgac gaattctgcc tcacccgtct gcagcgccag catggccaga tgaactgatt
     1381 tgagacctga accgcagacc ttgttaatcg tcagacattg cgtttcaacg ggtagcccgg
     1441 cgttcagcgc ggactgacgt gcgggattct ggccacatcc tgccgtcagt acctgtccca
     1501 taataacctg agaaatctca ctggcctcca ctcctgagtc ttcaagaagc gcacgaatga
     1561 cgtgactccc gagttctgct gcggaatggc ccgaaaggga acccatgaat gcaccggttg
     1621 cagtacgttt tgcagaaaca atcacaactt cgttcatgac atttcctctt tcaggccagg
     1681 cagagtatgg ccggtcgccg ccatagcggc gcggtaggcc gtcaggccgt tcatgcatgc
     1741 cggaacgccg gcatagatag ccatctgtat cacgatttca agcagctctt ccggggtgac
     1801 gccggtattg agtgccgctc tcatgtgtaa ttcaagctgt ggcattgcgt tacccagcgt
     1861 cacaagcgaa gcaaccgtca gcatttctct cgttctgaga tctagtccgg gacggccaac
     1921 cacagcacca aaagcgtaat cggtaatcag ggccggtaag gtggaatcaa gttcgctcag
     1981 tcgggtggtg actttatcgg cgagtccgga ctcaagacga tccataatat ctctgccata
     2041 acgtgtcagc tcatcagttg ggctcataat atttctccgg agtggtttgt tcagacctca
     2101 ggcgcgtcgg aatagcggca acgagcagga cagaaagtcc gatagctgcg ccggctgcga
     2161 tataaagcag tgggacggaa aaagcggata ccatccaggc acctgcagat gccccgacac
     2221 caatagcggt attgaagaat gaaacgtaaa ccgcggacgc cgggaaggct ttatcttccg
     2281 ccaggcgcag gacccacgtc tggaagccca caaaaatccc ggatacagcc acgccccaga
     2341 tgaccattgc ggtaaagacc gcagtgcctg aaagggatgt accggataaa cccagaaata
     2401 ccagcacagc acagataagc acgaccgata ccgataccgt tgctttgaga tgtttatcaa
     2461 tcaccattcc ggtgagaaaa ttgccggcaa gaccagcgat accgtaaaca aacagaaccg
     2521 ccgggatgac ggatgtggca agggaatgct gcgtgtgcag ccagggttca atgtatgtaa
     2581 aagcggcaaa gtgtgcggtt acggccagta acgtggcgga ataaattttc cacagcgcgg
     2641 aggatttaaa tacgcttttg agcgccccca ggccgatcgc acttttactg gttatctgtg
     2701 gcaccagtat ggtaatgccg gcaaaggcaa ccacgctgag taaagccatc agccagaacg
     2761 cctgtctcca gccgaagtgt ataccaatat aatttgatat cggcacgcca aatacgctgg
     2821 cagccgagac gccaccaaaa acgatagacg ttgccgcgcc aaggaatcgg gctggcacga
     2881 tagccactgc ggtggcgccg atcatcgccc agaatgagcc atgtgccagc gcgcccagta
     2941 cgcgtgcgac tagcagtatg gcgtatgtgt ttaccgtggc ggcaagaacg ttagaaagaa
     3001 aaagtatgac cgtgagtgtg agcagaagcc gcttcttggc cacgttacca agaaatactg
     3061 atgcaaagag tgcgctcagt gcgcccaccc aggcgtaaag tgaaaccgtc ataccaaccg
     3121 ctgactcaga ggcgccaagt ccctctgcaa tgggcgtcag caggcctacc ggagccagtt
     3181 cggtggtaac gatagtaaac gttgaaaggg ccagaataaa caaggcaagc caagacctga
     3241 aggtcatatc ctgcggggat ttttctgaat gcatatattc ttacctcaag gttggtttaa
     3301 atgacctgcc agcgatgtgt tatcgcgtgt ctggccagcg ctgaatgttt tcctacacag
     3361 acagggtggc cggttgatgc aagcatcgga atgtcagaga gatcgtcacc ataggcataa
     3421 cagtcagaag gattaatatt tctctgttcg caaaactgaa ggagcgcatc tttctttccg
     3481 tcaccaatcg tctgtggata acctatttca cccgtcattt cccctgcagc agtgaacttc
     3541 agtggtgcgc aaagaatatc ttgcacgcca aggtatcttg cgacaggaga aagaacggga
     3601 agcattgagc cggatataaa aacaatatcc atattttcag cctgatgttt tttaagagcc
     3661 gaaaccgcgc ttcctataaa taattctgaa ttcagcttaa atctgaacca tctttcacca
     3721 gcctcttcaa gtgccttata actgatacct gcaaattgcc ggtagtattc cctgttgaga
     3781 tgctcacggg gagttccttt tttaacttca gactggaaat tcgccatata attatggagt
     3841 ttaatgtgtt cattattctc cttgcaccag aagttaaaaa aatcaaacat acttttaata
     3901 ttgatcagcg tctcatcgac gtcaaaaaaa gcggctgctt gttgcaaaac tcactcctcg
     3961 taatttttcc ttcggctttt ttcctgaaaa tctttatggt ttccgggaac ccctgcgtct
     4021 gcccagcgag aaggatgtat ttcagaaatg acaaccgaga ttttatccag cggcgctccg
     4081 gtatgtttat gcacagcaaa cgtaatatct tcctggagcc ggataatttt accttcatct
     4141 tttacaggcc aggtggtgat gtgaacaaat ggcatatttt acctcactct acggtagtaa
     4201 attcatcaaa ggaacggacc tttagtttta aatgagcatg aatgtcacca cccagaccat
     4261 aaagtccgat tgcgccgccg tagctctggc gggaactcat atacaggaca acaacgttaa
     4321 taatccggtt ttcattccgt tcatgtgccg ggaagggatc gggcaattcc gcccagtaat
     4381 ctgcattacc gttatgatcg gtaataaata cgttaggtat gcccagaggt cccggtcggc
     4441 ttggattctc agtcgctaaa tctttttccc gaaggctcat cacggtataa acactgtcgg
     4501 gaacaagatt acggaaagaa aacgtaaacc ttgcgcgcct gctgtcttca gacagacaga
     4561 catccagcgt accctccgca tgcatccagt tttccagagt gacaggctga acctgacgtt
     4621 tgccatcact gctgcggtaa tcagcaatat agccttcatg cagaggcaga ctggggcggc
     4681 tttcggtgtt cgcctgcggc cgctgctccg gtgcaaaaag catcccgtaa ttatttgatg
     4741 ggatgggtaa aggaagggta tgcaggatga tatccttaac ttcatcctgc gacatacctt
     4801 caatatctcg cagtattctg taaggcttcg tcgcgccgaa ttcgggcacg gggctgtctg
     4861 ctgccacaag cacgcttcgc cattccagcc cgttatcacc cggcaccatg ccaaccacca
     4921 caaagttgcc gttaccgtcc atgacctccg caggggggta aagcggcccc tgcgtggtca
     4981 cagccaggcg gtatgttcgg ctagctgatt tggacatgcg tcaccccgtg tgtcgcgatg
     5041 ttctgttcag caattgccgc ctgcatggcg gcttcagcca gcagtttttc cttttcagca
     5101 atcagagctg aaggatatac ggtgaacgat acatccatcg tcgcgcaaag cgtctgatgc
     5161 tgagtcacgc gaacctgcgc tctgaaacgc ccccttcgct cattaatgtc cttctcaagg
     5221 aattcaaaat ggaccagcgc tggtaaagga aacagaaagc tggaaaaggt cgtcgccatg
     5281 ctgttaatga cgtagtagcg tcctgcttcc tgcttataaa taaactcttc ggtaacggcg
     5341 ataaaagcct gacgacttgc ctcgaccaga agcatcccct gaatatgctg gccggtctga
     5401 tgatcggcca tgagctcaca gcgttcgtca atcagcagcg gcattgcaaa aagatcactg
     5461 ttatgttcgg tctgctctgc tgagccgata agaacattct gctccagcct tttatgacaa
     5521 tgtgcatttt ttttatctct gaccaatttt tccagagagc acattttaag tttattgcca
     5581 tgaacaacat ttcttgcctg attcgaaatg acttttcctg cgaaatcttt acgtacaccc
     5641 tggccgataa taatctcatg ttctttatca ataatgttgg ctggaatttg cgaaagtaat
     5701 tcaagctgag aaattgtcag aacatcttta ccatttgcga attcattaaa cttatcgcct
     5761 acaataacca gttttttata gttcatttat cattcctcag ctgcaacagg catggtagat
     5821 gcgggtgtaa agtccttcat tgcctccggt gatgtaattg tctccagctt gctggataat
     5881 ttcctggtaa cgcgcattgg tgaaggcttc cttataggat tgcttatcgc cattgaagga
     5941 ggagataaac attacacccg gaacaccgct aataagagag tggaatgctt caaagctttc
     6001 aattttatct ttattgtccc tgacaacatt aaaaatggtc tcatcgcgcc actgacgata
     6061 ctgctgataa ttatgagccg gaacttcaac atggcgaagt tgaatgtact ggctttcagg
     6121 gagatctttc ttgttgtcaa tcggagattc tacaaactta agcaattctc tgcgaatatc
     6181 tgcagaaaga acatcagcca gcctgtggaa catggatacc atctcttctt ctacccacga
     6241 aatttccttg atgtcgttaa atgcacgcag ctccagaagt tcattcactc cctgctcttc
     6301 tgaataatag tatcgtgtgc tgccgctgtt ttttaagaac gagaaatcag cagcggaaac
     6361 attatttttt aacggaaagc gtgagaccag tacatagtta gctgacattt tcatctccaa
     6421 atagatttct gattgagttc gggagaaatt tatcaatctg tgacgaggat ggaattgttt
     6481 aatgtgtaat tcaattttcg tattactgta aacagactga tccctgatat gatcattcgt
     6541 gttaacactc agaatacaaa agagtttaga ataaaatttt tgactggcag gctcgaatct
     6601 atggcgatcg caggacacct gataagtaac cacctcccca gcgttaaaca gctccagtgc
     6661 ttccttgctg ttgctcatga actgaatttt cgcagagctg ctgaacggct cagaatgact
     6721 cagcctccgt taacccgaca tataaagtgc ctcgaaggcg tgctgaatca gcagttattc
     6781 agccgcagta cgcatgacgt cagcctgacg gaggctggcc aggccctggt aataagagca
     6841 gagaagattc tgctggagct taatgaactg aaaaccggtt cactggcatc cggggggaag
     6901 gtacggatcg gccttacccg gacgcttaat tttgaattta tcgaacccgt cagcagacag
     6961 cttatcgaac tggatgccgg agacgacgtt gaaacaccta atctgacttc tgcccagctc
     7021 cttcaatgcc tgtcaaaaaa cacgcttgat ctcgtgctta cgggggaaaa gggcactggc
     7081 catgaagata tggttcagta tcgctgggtt tgctgcgaac cgctgctgat agcaatgccg
     7141 gccatacatc ccgccagcct gaaagaaaaa gtatcactca aagacgtcag tgatttacca
     7201 cttttctggt tttcaagaag cgcaaaccct tcattttatg acaaatgtga aagttttttt
     7261 gaacagctca atgtcccgct caaaagggtt aaagagccgg atgattcact cgttatgctc
     7321 acccgcatcg caagaggcaa agggtttgca ctgatgcccc agtcgaaatg cacgtttaat
     7381 caggaagggc tgtgctaccg cgaactgaca gacgatgaat ctcagaaact gaatattgat
     7441 atctactcgg caatcagggt caatgagacg cgggaggctg tactggatgc tcagaacgtc
     7501 ttatgtggga aaaatttttc cggctgaaga gtttatatgg ggtcatgatt ggatagcgaa
     7561 aattattata ctacaagggc ttacccggca tgagatggca ggcacgcctc tctatctgac
     7621 gtcgccaggc tacaataatc actgaatccc aggcgcttga acaactgtac ttctttatcc
     7681 tggcgctacg tctctctttc actttgtcat gagatactgc tatctatgag caacgtcacc
     7741 atttatcaca atctggcctg cgggacggta tcattatcgc tgaacgatat tctggagggt
     7801 gactatgact attatctgca gacgcttcct gatgccgctt atgcagtttc agccagtatt
     7861 gaatattaat aatgcctggc tgaataagaa ccctggtcag gtaagctgga aaatcaccaa
     7921 taatcatcgc cagcggcaat aacatgacgc tgccgtaatg ggatatcgat gttactgatc
     7981 tttggcggcc tgcccggtac cgggaaatca accattgctc gcctgctggc cgccaggctg
     8041 ggggccgtct ggttacggat tgattcaatt gaacaggcgc tgattcgcgc cgaaaccgtc
     8101 acccggcacg atatagggcc ggccggatat ctggtggcgt atgccattgc tgcggataac
     8161 ctcaggcagg gcaacgtggt gattgccgac tcagttaacc ctatagccat tacccgccag
     8221 gcatggagag cggtcgcgac cgagaatgcc gcgccttatc tggagataga actgacctgc
     8281 tccgaccaaa tgcagcatcg gtatcgcgtg gaaaaccgag tggcggatat tcgcggccat
     8341 attctgccgg actggcaaaa ggttatcgcc cgtgagtacg aaccctggcg caccgccagc
     8401 ctgactctgg atacctcggt gctgaccgcc gaagaggcgg tagagcggat cgttgagcat
     8461 attgcgttac gcggccgcca cgcgccggta ggttcataga agccgccggg catcggcggc
     8521 aaaaacctac ataaagaatt tcacggcctg ctggagggtg gtaccgacgc cccataacag
     8581 cggcacgctc accgctaacc agcttatggt taacagcagc gtggacgggc ggggctccca
     8641 cgtgagctgg gcatccttgt tgatggtata cagtcctttc gcctgctgct gctgttccgc
     8701 ggtcatcgca tgctcttccg tcagcggacg caccagctga ttacagataa aacccaacac
     8761 cagcaggccg gtcaggacca tcagcgtaat atcgtagacg cgctcgggcg aaaccccgtg
     8821 cgttagctga tactcgcgca gatagttcac cagaaccggg ccgctgatcc ccgccgccga
     8881 ccaggcggtt aacaggcgcc cgtgaatcgc gcccaccatt tgtgagccaa agacgtcggc
     8941 cagataggcg ggaatactgg caaagcctcc gccgtacatc gaaatgataa tgcacattgc
     9001 gcagacatac agcgcgatat agccgccgtg attcaccagc ggcaacgtgc cgtacagcac
     9061 ggcgcccagg cagaaaatga tcgcaaaggt cattttgcgc ccgcacaggt cggataccga
     9121 tgcccagaaa aaacgtccca ggatgttaaa caggctgagc agaccggtaa atcctgcggc
     9181 catggttgca atgcgtttca gctgctcgcc gttcagctca tgccaactga gatcgagcga
     9241 cagcagtttg ccggcaaaga tctcctgcag catcggcgaa gccataccga gaatgccgat
     9301 ccccgcggtg acgttgagcc acagcaccat ccacagcagc cagaactgcg gagtgcggca
     9361 ggcaacgcgg acgtgcacct ggatcgtggg attattgcgg atcgtttttt gcgccttctc
     9421 acccgaagga tgccagccca tgggcggcag gcgatagcca aaggtaccgg cgagcataaa
     9481 cagcgcataa atcgccgcca gcgccagaat gctttgccat accccgttgc cggccggccc
     9541 ggcgaagtaa ttcatcagac cgtttgccag cggcgcgccc accagcgctc ccccgccaaa
     9601 acccataatc gccatcccgg ccgccattcc gcgcttgtca ggaaaccagc gcaacagcgt
     9661 cgaaaccggt gaaatatagc ccagtccgag accgattccg ccgatgaccc cggcccccag
     9721 ccacagcagc catagctgat ggaaatagat agcgacgctg gatagcagca ggccgccgca
     9781 ccagcacaag gtggcaataa agctcaccag ccgcggtcca accttctcaa gccagctgcc
     9841 ccacagcgcc gccgaacagc cgagaaaaac aaaaaacagc gtgtaggtcc agcccagcat
     9901 ggagattttc cagtcgcaat cgcgggtaaa cagctgctgc cagaacgaca tcgtgacggg
     9961 gcattgcaag gacgcgcttc ctcctatgag ctgcgacata ggcagccagt aaacggaaaa
    10021 tccataggcc atacctatgc agagatgaac cgccagcgcg gccggtggca ccagccagcg
    10081 gttaaagccg ggcctggcga tgatacgggg tttcgcgaaa aaatcgcgga ggggagagac
    10141 cggtgcggtc gcgatgtttt cattcatttg cgccattttc ctgtcctttt tatcgatatt
    10201 agccgacgaa tgctgcggtc ggggaacgta gataaaaggc aagaacggtg ccatttgatt
    10261 aaattgtgta caaaaatggc gactgaagcg agcaagcttc gccgaacggc tgaggcgaaa
    10321 agccctccat cggcgaagga ggcaccgccc gcgataaaat cgccgggcgc gctattattt
    10381 tgataaacgg cgatctcaga gtgatacgcg gtaccaggtg gcgagggcgc gtaccggcct
    10441 gctcgcccgc cgctcgttag cttaaggtat caatccattc gctctggcgc gggttctgcc
    10501 gacgatagca gtgtaccgac accgccagct gcgtcaggtc ggtgaagacc atcggatcga
    10561 gctgaatatg ctttttaatc tgctgtagcc ggtaggtgag cgtattgcga tgaatcccca
    10621 acagcagcga cgttttgccc ggctcggcgt tattggcaat aaagctgctg agggtatcca
    10681 gcagcacttc gccggaatca tgctcaagca gctggcgtac gttattgatg aaaaaattga
    10741 ccatatagct gtcttccagc acccggaaca ggcagagcat cgccat
//
