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Overview
1.1
1.2
1.3
1.4
1.5

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_GL622359.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS | 15,705 | 59,316 |
Region 1.2 | ranthipeptide | 204,555 | 225,949 |
Region 1.3 | NRPS | 850,484 | 894,771 |
Region 1.4 | NRPS | 1,160,840 | 1,209,358 |
Region 1.5 | NRPS,NRPS-like | 1,323,103 | 1,378,400 |

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS | 15,705 | 59,316 |
Region 1.2 | ranthipeptide | 204,555 | 225,949 |
Region 1.3 | NRPS | 850,484 | 894,771 |
Region 1.4 | NRPS | 1,160,840 | 1,209,358 |
Region 1.5 | NRPS,NRPS-like | 1,323,103 | 1,378,400 |

No secondary metabolite regions were found in these records:
  NZ_GL622360.1
  NZ_GL622361.1
  NZ_GL622362.1
  NZ_GL622363.1
  NZ_GL622364.1
  NZ_GL622365.1

Compact view
NZ_GL622359.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 15,705 - 59,316 nt. (total: 43,612 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.23 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000427.1 |  | 0.21 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001479.1 |  | 0.21 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000410.1 |  | 0.21 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001135.1 |  | 0.21 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000343.1 |  | 0.21 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001166.1 |  | 0.21 | NRP | HC-toxin | Alternaria jesenskae
BGC0001220.1 |  | 0.20 | NRP | aculeacin A | Aspergillus japonicus
BGC0001132.1 |  | 0.20 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001261.1 |  | 0.20 | NRP | AM-toxin | Alternaria alternata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001891.1 |  | 0.56 | Other | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001479.1 |  | 0.54 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0000410.1 |  | 0.54 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001135.1 |  | 0.54 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000343.1 |  | 0.53 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001166.1 |  | 0.53 | NRP | HC-toxin | Alternaria jesenskae
BGC0001220.1 |  | 0.53 | NRP | aculeacin A | Aspergillus japonicus
BGC0001132.1 |  | 0.53 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001261.1 |  | 0.53 | NRP | AM-toxin | Alternaria alternata

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 15704 - 59316:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Me-cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_26: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (466..827): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)

NZ_GL622359.1 - Region 2 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 204,555 - 225,949 nt. (total: 21,395 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or YcaO or TIGR03882)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000764.1 |  | 0.14 | Saccharide | exopolysaccharide | Lactococcus lactis
BGC0000019.1 |  | 0.13 | Polyketide | angolamycin | Streptomyces eurythermus
BGC0000803.1 |  | 0.13 | Saccharide | GG exopolysaccharide | Lactobacillus rhamnosus GG
BGC0000820.1 |  | 0.13 | Alkaloid | physostigmine | Streptomyces griseofuscus
BGC0001677.1 |  | 0.11 | Polyketide | mycophenolic acid | Penicillium roqueforti
BGC0001360.1 |  | 0.09 | Polyketide | mycophenolic acid | Penicillium roqueforti FM164
BGC0000104.1 |  | 0.07 | Polyketide, Terpene | mycophenolic acid | Penicillium brevicompactum
BGC0000148.1 |  | 0.03 | Polyketide | A83543A | Saccharopolyspora spinosa
BGC0000055.1 |  | 0.03 | Polyketide, Saccharide | erythromycin A, erythromycin B, erythromycin C, erythromycin D | Saccharopolyspora erythraea NRRL 2338

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000764.1 |  | 0.43 | Saccharide | exopolysaccharide | Lactococcus lactis
BGC0000019.1 |  | 0.42 | Polyketide | angolamycin | Streptomyces eurythermus
BGC0000803.1 |  | 0.41 | Saccharide | GG exopolysaccharide | Lactobacillus rhamnosus GG
BGC0000820.1 |  | 0.41 | Alkaloid | physostigmine | Streptomyces griseofuscus
BGC0001677.1 |  | 0.38 | Polyketide | mycophenolic acid | Penicillium roqueforti
BGC0001360.1 |  | 0.33 | Polyketide | mycophenolic acid | Penicillium roqueforti FM164
BGC0000104.1 |  | 0.29 | Polyketide, Terpene | mycophenolic acid | Penicillium brevicompactum
BGC0000148.1 |  | 0.17 | Polyketide | A83543A | Saccharopolyspora spinosa
BGC0000055.1 |  | 0.16 | Polyketide, Saccharide | erythromycin A, erythromycin B, erythromycin C, erythromycin D | Saccharopolyspora erythraea NRRL 2338

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_GL622359.1 - Region 3 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 850,484 - 894,771 nt. (total: 44,288 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.32 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.32 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000900.1 |  | 0.32 | Other | ferrichrome | Aspergillus oryzae
BGC0001249.1 |  | 0.31 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000348.1 |  | 0.31 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0000876.1 |  | 0.29 | Other | neopolyoxin C | Streptomyces tendae
BGC0000921.1 |  | 0.27 | Other (Shikimate-derived), Polyketide, NRP | promysalin | Pseudomonas putida
BGC0001479.1 |  | 0.26 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001399.1 |  | 0.25 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001261.1 |  | 0.24 | NRP | AM-toxin | Alternaria alternata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.66 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.65 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000900.1 |  | 0.65 | Other | ferrichrome | Aspergillus oryzae
BGC0001249.1 |  | 0.65 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000348.1 |  | 0.64 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0000876.1 |  | 0.63 | Other | neopolyoxin C | Streptomyces tendae
BGC0000921.1 |  | 0.61 | Other (Shikimate-derived), Polyketide, NRP | promysalin | Pseudomonas putida
BGC0001479.1 |  | 0.59 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102
BGC0001399.1 |  | 0.59 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001261.1 |  | 0.58 | NRP | AM-toxin | Alternaria alternata

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 850483 - 894771:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_802: X - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (13..458): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      GfFgfgAfAK
    Nearest Stachelhaus code:
      2-oxo-isovaleric-acid
    Stachelhaus code match:
      50% (weak)
  AMP-binding (1133..1525): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNiSMIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)
ctg1_811: ala
  Search NORINE for peptide: strict or relaxed
  AMP-binding (8..410): ala
  NRPSPredictor2: ala
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      N/A
    Single AA prediction:
      ala
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLMVLCTVcK
    Nearest Stachelhaus code:
      ala
    Stachelhaus code match:
      90% (moderate)

NZ_GL622359.1 - Region 4 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,160,840 - 1,209,358 nt. (total: 48,519 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000343.1 |  | 0.23 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001343.1 |  | 0.23 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000375.1 |  | 0.23 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001168.1 |  | 0.22 | NRP | livipeptin | Streptomyces lividans 1326
BGC0000632.1 |  | 0.22 | Terpene, Saccharide | brasilicardin A | Nocardia terpenica
BGC0001615.1 |  | 0.22 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001591.1 |  | 0.21 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.21 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000653.1 |  | 0.21 | Terpene | pentalenolactone | Streptomyces arenae
BGC0001135.1 |  | 0.20 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000343.1 |  | 0.57 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001343.1 |  | 0.56 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000375.1 |  | 0.56 | NRP | indigoidine | Streptomyces chromofuscus
BGC0001168.1 |  | 0.55 | NRP | livipeptin | Streptomyces lividans 1326
BGC0000632.1 |  | 0.55 | Terpene, Saccharide | brasilicardin A | Nocardia terpenica
BGC0001615.1 |  | 0.55 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001591.1 |  | 0.54 | Other | fatty acid enol ester | uncultured bacterium CSLC2
BGC0001688.1 |  | 0.54 | Other | N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000653.1 |  | 0.53 | Terpene | pentalenolactone | Streptomyces arenae
BGC0001135.1 |  | 0.53 | NRP | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 1160839 - 1209358:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Me-cys - Me-cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1086: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (54..270): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    Predicted physicochemical class:
      N/A
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      --WAIgv--K
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      40% (weak)
ctg1_1087: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (36..412): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      ayvpIGGpqK
    Nearest Stachelhaus code:
      val
    Stachelhaus code match:
      40% (weak)
ctg1_1090: cys - cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (465..842): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1879..2249): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNlSLVWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)
ctg1_1092: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (19..350): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      val, leu, ile, abu, iva
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      sFcyVsqslK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      30% (weak)

NZ_GL622359.1 - Region 5 - NRPS,NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,323,103 - 1,378,400 nt. (total: 55,298 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | NRPS-like | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0000427.1 |  |  |  | 0.99 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  |  |  | 0.97 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000900.1 |  |  |  | 0.95 | Other | ferrichrome | Aspergillus oryzae
BGC0001527.1 |  |  |  | 0.94 | Other | basidioferrin | Gelatoporia subvermispora
BGC0000348.1 |  |  |  | 0.93 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001249.1 |  |  |  | 0.92 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000460.1 |  |  |  | 0.90 | NRP | vulnibactin | Vibrio vulnificus CMCP6
BGC0002002.1 |  |  |  | 0.90 | NRP | 1,6-phenazinedimethanol, fontizine A | Serratia fonticola
BGC0000352.1 |  |  |  | 0.84 | NRP | fimsbactin A | Acinetobacter sp. ADP1
BGC0000921.1 |  |  |  | 0.83 | Other (Shikimate-derived), Polyketide, NRP | promysalin | Pseudomonas putida

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000427.1 |  | 0.66 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0000375.1 |  | 0.66 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000900.1 |  | 0.65 | Other | ferrichrome | Aspergillus oryzae
BGC0001527.1 |  | 0.65 | Other | basidioferrin | Gelatoporia subvermispora
BGC0000348.1 |  | 0.64 | NRP | ergovaline | Epichloe festucae var. lolii
BGC0001249.1 |  | 0.64 | NRP | dimethylcoprogen | Alternaria alternata
BGC0000460.1 |  | 0.64 | NRP | vulnibactin | Vibrio vulnificus CMCP6
BGC0002002.1 |  | 0.63 | NRP | 1,6-phenazinedimethanol, fontizine A | Serratia fonticola
BGC0000352.1 |  | 0.62 | NRP | fimsbactin A | Acinetobacter sp. ADP1
BGC0000921.1 |  | 0.61 | Other (Shikimate-derived), Polyketide, NRP | promysalin | Pseudomonas putida

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 5, location 1323102 - 1378400:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys) + (cys) + (cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 1323102 - 1368625:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys) + (cys) + (cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 7, location 1329839 - 1371797:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys) + (cys) + (cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 1335748 - 1378400:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (cys) + (cys) + (cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1272: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (703..1086): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNiSMIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)
ctg1_1274: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (18..221): X
  NRPSPredictor2: hydrophobic-aliphatic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      ----IAA--K
    Nearest Stachelhaus code:
      phe
    Stachelhaus code match:
      40% (weak)
ctg1_1275: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (0..348): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLYNMSLiWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      90% (moderate)
ctg1_1281: cys
  Search NORINE for peptide: strict or relaxed
  AMP-binding (1..388): cys
  NRPSPredictor2: cys
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      cys
    Small clusters prediction:
      cys
    Single AA prediction:
      cys
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DLFNLSLIWK
    Nearest Stachelhaus code:
      cys
    Stachelhaus code match:
      100% (strong)