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Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP040105.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | redox-cofactor,NRPS | 123,527 | 180,003 | lankacidin C | NRP + Polyketide | 13%
Region 2 | betalactone | 530,260 | 559,340 | mycosubtilin | NRP + Polyketide | 20%
Region 3 | RiPP-like | 686,245 | 697,108 |
Region 4 | arylpolyene | 1,166,063 | 1,206,544 | berninamycin A | RiPP | 26%
Region 5 | NRPS,hserlactone,arylpolyene | 1,870,365 | 1,949,214 | K53 capsular polysaccharide | Saccharide | 10%
Region 6 | NAPAA | 2,881,492 | 2,915,490 |
Region 7 | siderophore | 3,526,754 | 3,543,181 | staphylobactin | Other | 12%

NZ_CP040105.1 - Region 1 - NRPS,redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 123,527 - 180,003 nt. (total: 56,477 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))
NRPS: cds(Condensation and (AMP-binding or A-OX))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000401.1 |  |  | 0.35 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001615.1 |  |  | 0.33 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000905.1 |  |  | 0.28 | Other | heme D1 | Heliobacillus mobilis
BGC0001184.1 |  |  | 0.28 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  |  | 0.28 | Other | bacilysin | Bacillus sp. CS93
BGC0000410.1 |  |  | 0.27 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001149.1 |  |  | 0.27 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001833.1 |  |  | 0.26 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000321.1 |  |  | 0.26 | NRP | chaetocin | Collariella virescens
BGC0001132.1 |  |  | 0.26 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000401.1 |  | 0.68 | NRP | paenibactin | Paenibacillus elgii B69
BGC0001615.1 |  | 0.66 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001184.1 |  | 0.61 | Other | bacilysin | Bacillus velezensis FZB42
BGC0000888.1 |  | 0.61 | Other | bacilysin | Bacillus sp. CS93
BGC0000410.1 |  | 0.61 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001149.1 |  | 0.60 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001833.1 |  | 0.60 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0000321.1 |  | 0.60 | NRP | chaetocin | Collariella virescens
BGC0001132.1 |  | 0.59 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.1 |  | 0.59 | NRP | xenematide | Xenorhabdus nematophila AN6/1

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 123526 - 180003:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 133526 - 180003:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_126: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (36..446): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      SMACQGVVNK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      100% (strong)
ctg1_131: X - ser
  Search NORINE for peptide: strict or relaxed
  AMP-binding (478..892): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DslDLGlVDK
    Nearest Stachelhaus code:
      gln
    Stachelhaus code match:
      70% (weak)
  AMP-binding (1538..1943): ser
  NRPSPredictor2: ser
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      ser
    Single AA prediction:
      ser
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DVWHFSLVDK
    Nearest Stachelhaus code:
      ser
    Stachelhaus code match:
      100% (strong)

NZ_CP040105.1 - Region 2 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 530,260 - 559,340 nt. (total: 29,081 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000258.1 |  | 0.21 | Polyketide | prodigiosin | Serratia sp.
BGC0001897.1 |  | 0.20 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000259.1 |  | 0.20 | Polyketide | prodigiosin | Serratia marcescens
BGC0000234.1 |  | 0.20 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000890.1 |  | 0.20 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000891.1 |  | 0.20 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0001983.1 |  | 0.17 | Other | triacsins | Kitasatospora aureofaciens
BGC0000373.1 |  | 0.16 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0001940.1 |  | 0.16 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0001730.1 |  | 0.15 | Polyketide | paramagnetoquinone 1, paramagnetoquinone 2 | Actinoallomurus sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000258.1 |  | 0.53 | Polyketide | prodigiosin | Serratia sp.
BGC0001897.1 |  | 0.52 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000259.1 |  | 0.52 | Polyketide | prodigiosin | Serratia marcescens
BGC0000234.1 |  | 0.52 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000890.1 |  | 0.52 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas phenolica O-BC30
BGC0000891.1 |  | 0.52 | Other (Aminocoumarin) | pentabromopseudilin | Pseudoalteromonas luteoviolacea 2ta16
BGC0001983.1 |  | 0.48 | Other | triacsins | Kitasatospora aureofaciens
BGC0000373.1 |  | 0.47 | NRP | holomycin | Streptomyces clavuligerus ATCC 27064
BGC0001940.1 |  | 0.46 | Polyketide | pyxidicycline A, pyxidicycline B | Pyxidicoccus fallax
BGC0001730.1 |  | 0.45 | Polyketide | paramagnetoquinone 1, paramagnetoquinone 2 | Actinoallomurus sp.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP040105.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 686,245 - 697,108 nt. (total: 10,864 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001850.1 |  | 0.13 | Other (Shikimate-derived) | diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G | Streptomyces sp. F001
BGC0000232.1 |  | 0.08 | Polyketide | hatomarubigin A, hatomarubigin B, hatomarubigin C, hatomarubigin D | Streptomyces sp. 2238-SVT4
BGC0001429.1 |  | 0.07 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca DW4/3-1
BGC0001431.1 |  | 0.07 | NRP, Polyketide | myxochromide S | Stigmatella aurantiaca
BGC0001500.1 |  | 0.07 | Polyketide | allocyclinone | Actinoallomurus sp. ID145698
BGC0001292.1 |  | 0.06 | Other | A33853 | Streptomyces sp. NRRL 12068
BGC0001376.1 |  | 0.04 | Polyketide | WS79089A, hexaricin B, hexaricin C | Streptosporangium sp. FXJ7.131
BGC0001960.1 |  | 0.04 | Polyketide | hiroshidine | Streptomyces hiroshimensis
BGC0000212.1 |  | 0.04 | Polyketide | cinerubin B | Streptomyces sp. SPB074
BGC0001503.1 |  | 0.04 | Polyketide | amycolamycin A, amycolamycin B | Amycolatopsis sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001850.1 |  | 0.41 | Other (Shikimate-derived) | diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G | Streptomyces sp. F001
BGC0000232.1 |  | 0.32 | Polyketide | hatomarubigin A, hatomarubigin B, hatomarubigin C, hatomarubigin D | Streptomyces sp. 2238-SVT4
BGC0001429.1 |  | 0.28 | NRP, Polyketide | myxochromide S1 | Stigmatella aurantiaca DW4/3-1
BGC0001431.1 |  | 0.28 | NRP, Polyketide | myxochromide S | Stigmatella aurantiaca
BGC0001500.1 |  | 0.27 | Polyketide | allocyclinone | Actinoallomurus sp. ID145698
BGC0001292.1 |  | 0.25 | Other | A33853 | Streptomyces sp. NRRL 12068
BGC0001376.1 |  | 0.20 | Polyketide | WS79089A, hexaricin B, hexaricin C | Streptosporangium sp. FXJ7.131
BGC0001960.1 |  | 0.19 | Polyketide | hiroshidine | Streptomyces hiroshimensis
BGC0000212.1 |  | 0.19 | Polyketide | cinerubin B | Streptomyces sp. SPB074
BGC0001503.1 |  | 0.19 | Polyketide | amycolamycin A, amycolamycin B | Amycolatopsis sp.

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP040105.1 - Region 4 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,166,063 - 1,206,544 nt. (total: 40,482 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.1 |  | 0.22 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000780.1 |  | 0.19 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0002008.1 |  | 0.17 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.17 | Other | APE Ec | Escherichia coli CFT073
BGC0001897.1 |  | 0.17 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001739.1 |  | 0.16 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001343.1 |  | 0.16 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001120.1 |  | 0.15 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001917.1 |  | 0.15 | Polyketide | 5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals | Streptomyces nigrescens
BGC0000275.1 |  | 0.14 | Polyketide | tetracenomycin C | Streptomyces glaucescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000779.1 |  | 0.54 | Saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0000780.1 |  | 0.51 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0002008.1 |  | 0.48 | Other | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.1 |  | 0.48 | Other | APE Ec | Escherichia coli CFT073
BGC0001897.1 |  | 0.48 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001739.1 |  | 0.47 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001343.1 |  | 0.46 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0001120.1 |  | 0.45 | NRP, Polyketide | burkholderic acid | Burkholderia thailandensis E264
BGC0001917.1 |  | 0.45 | Polyketide | 5-alkyl-1,2,3,4-tetrahydroquinolines, streptoaminals | Streptomyces nigrescens
BGC0000275.1 |  | 0.44 | Polyketide | tetracenomycin C | Streptomyces glaucescens

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_CP040105.1 - Region 5 - NRPS,arylpolyene,hserlactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,870,365 - 1,949,214 nt. (total: 78,850 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
hserlactone: Autoind_synth
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | hserlactone | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0000343.1 |  |  |  | 0.72 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001983.1 |  |  |  | 0.63 | Other | triacsins | Kitasatospora aureofaciens
BGC0001343.1 |  |  |  | 0.62 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000220.1 |  |  |  | 0.55 | Polyketide | enterocin | Streptomyces maritimus
BGC0000274.1 |  |  |  | 0.52 | Polyketide | tetarimycin A, tetarimycin B | uncultured bacterium
BGC0000313.1 |  |  |  | 0.49 | NRP | beauvericin | Beauveria bassiana
BGC0000246.1 |  |  |  | 0.49 | Polyketide | mithramycin | Streptomyces argillaceus
BGC0001739.1 |  |  |  | 0.49 | Other | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001897.1 |  |  |  | 0.49 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0001831.1 |  |  |  | 0.47 | Polyketide | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000760.1 |  | 0.67 | Saccharide | emulsan | Acinetobacter venetianus RAG-1 = CIP 110063
BGC0001890.1 |  | 0.65 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0001615.1 |  | 0.65 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000343.1 |  | 0.64 | NRP | enterobactin | Pseudomonas sp. J465
BGC0001399.1 |  | 0.64 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0000417.1 |  | 0.61 | NRP | rhodochelin | Rhodococcus jostii RHA1
BGC0000389.1 |  | 0.60 | NRP | massetolide A | Pseudomonas fluorescens SS101
BGC0001386.1 |  | 0.59 | Polyketide | JBIR-76, JBIR-77 | Streptomyces sp. RI-77
BGC0000255.1 |  | 0.59 | Polyketide | pederin | Uncultured bacterium
BGC0001625.1 |  | 0.59 | Polyketide | isofuranonaphthoquinone | Streptomyces sp. CB01883

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 1870364 - 1949214:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 1870364 - 1914324:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_1714: gly
  Search NORINE for peptide: strict or relaxed
  AMP-binding (487..872): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DIvQiGiVWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      70% (weak)
ctg1_1717: pk
  CAL_domain (156..486): pk
  minowa: NH2
  Prediction, score:
    NH2: 120.0
    Acetyl-CoA: 58.4
    fatty_acid: 20.3
    shikimic_acid: 0.0
    AHBA: 0.0
ctg1_1725: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (38..443): X
  NRPSPredictor2: (unknown)
  SVM prediction details:
    NOTE: outside applicability domain
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      ayyaSAHmVK
    Nearest Stachelhaus code:
      pip
    Stachelhaus code match:
      50% (weak)

NZ_CP040105.1 - Region 6 - NAPAA
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,881,492 - 2,915,490 nt. (total: 33,999 nt) Show pHMM detection rules used
NAPAA: (AMP-binding and PP-binding and TIGR02353)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NAPAA | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000375.1 |  | 0.22 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.21 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001399.1 |  | 0.20 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001561.1 |  | 0.19 | NRP | curacomycin | Streptomyces curacoi
BGC0000780.1 |  | 0.18 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000328.1 |  | 0.18 | NRP | coronatine | Pseudomonas savastanoi pv. glycinea
BGC0001778.1 |  | 0.18 | Other | showdomycin | Streptomyces showdoensis
BGC0001615.1 |  | 0.18 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001641.1 |  | 0.18 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1 |  | 0.18 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000375.1 |  | 0.55 | NRP | indigoidine | Streptomyces chromofuscus
BGC0000427.1 |  | 0.54 | NRP | shinorine, 4-deoxygadusol, mycosporine glycine | Trichormus variabilis ATCC 29413
BGC0001399.1 |  | 0.53 | NRP | fellutamide B | Aspergillus nidulans FGSC A4
BGC0001561.1 |  | 0.51 | NRP | curacomycin | Streptomyces curacoi
BGC0000780.1 |  | 0.50 | Saccharide | O&K-antigen | Vibrio parahaemolyticus
BGC0000328.1 |  | 0.50 | NRP | coronatine | Pseudomonas savastanoi pv. glycinea
BGC0001778.1 |  | 0.50 | Other | showdomycin | Streptomyces showdoensis
BGC0001615.1 |  | 0.50 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0001641.1 |  | 0.50 | NRP | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001479.1 |  | 0.50 | NRP | anabaenopeptin NZ857, nostamide A | Nostoc punctiforme PCC 73102

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 11, location 2881491 - 2915490:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_2621: X
  Search NORINE for peptide: strict or relaxed
  AMP-binding (31..418): X
  NRPSPredictor2: hydrophilic
  SVM prediction details:
    Predicted physicochemical class:
      hydrophilic
    Large clusters prediction:
      N/A
    Small clusters prediction:
      N/A
    Single AA prediction:
      N/A
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DmEHNgTVtK
    Nearest Stachelhaus code:
      dab
    Stachelhaus code match:
      70% (weak)

NZ_CP040105.1 - Region 7 - siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,526,754 - 3,543,181 nt. (total: 16,428 nt) Show pHMM detection rules used
siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000295.1 |  | 0.32 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0000942.1 |  | 0.27 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0001453.1 |  | 0.27 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000294.1 |  | 0.23 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000946.1 |  | 0.22 | Other | vibrioferrin | Vibrio parahaemolyticus
BGC0000939.1 |  | 0.20 | Other | aerobactin | Grimontia hollisae
BGC0000943.1 |  | 0.17 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000896.1 |  | 0.14 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000774.1 |  | 0.14 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0001587.1 |  | 0.14 | Other | ethylenediaminesuccinic acid hydroxyarginine (EDHA) | Streptomyces avermitilis MA-4680 = NBRC 14893

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000295.1 |  | 0.65 | NRP | acinetoferrin | Acinetobacter haemolyticus
BGC0000942.1 |  | 0.61 | Other | petrobactin | Bacillus anthracis str. Ames
BGC0001453.1 |  | 0.61 | Other | desferrioxamine | Streptomyces argillaceus
BGC0000294.1 |  | 0.57 | NRP | acinetobactin | Acinetobacter baumannii
BGC0000946.1 |  | 0.55 | Other | vibrioferrin | Vibrio parahaemolyticus
BGC0000939.1 |  | 0.53 | Other | aerobactin | Grimontia hollisae
BGC0000943.1 |  | 0.49 | Other | staphylobactin | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000896.1 |  | 0.44 | Other | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000774.1 |  | 0.44 | Saccharide | lipopolysaccharide | Xanthomonas campestris pv. campestris
BGC0001587.1 |  | 0.43 | Other | ethylenediaminesuccinic acid hydroxyarginine (EDHA) | Streptomyces avermitilis MA-4680 = NBRC 14893

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names