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Overview
1.1
1.2
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1.4
1.5

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_KB375281.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1 | terpene | 279,590 | 302,955 | malleobactin A / malleobactin B / malleobactin C / malleobactin D | NRP:NRP siderophore | 11%
Region 2 | redox-cofactor | 568,183 | 590,460 |
Region 3 | terpene | 888,388 | 909,251 |
Region 4 | RiPP-like | 2,233,615 | 2,244,418 |
Region 5 | RRE-containing | 2,994,064 | 3,014,486 |

NZ_KB375281.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 279,590 - 302,955 nt. (total: 23,366 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.32 | Terpene | carotenoid | Myxococcus xanthus
BGC0001361.1 |  | 0.27 | Terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0000646.1 |  | 0.24 | Terpene | β-carotein | uncultured bacterium
BGC0000630.1 |  | 0.24 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000656.1 |  | 0.24 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000668.1 |  | 0.23 | Terpene, Alkaloid | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0000640.1 |  | 0.23 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0001594.1 |  | 0.23 | Alkaloid | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000635.1 |  | 0.21 | Terpene | carotenoid | Paracoccus sp. N81106
BGC0000642.1 |  | 0.20 | Terpene | carotenoid | Enterobacteriaceae bacterium DC413

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000648.1 |  | 0.66 | Terpene | carotenoid | Myxococcus xanthus
BGC0001361.1 |  | 0.61 | Terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0000646.1 |  | 0.58 | Terpene | β-carotein | uncultured bacterium
BGC0000630.1 |  | 0.57 | Terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000656.1 |  | 0.57 | Terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000668.1 |  | 0.56 | Terpene, Alkaloid | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0000640.1 |  | 0.56 | Terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0001594.1 |  | 0.56 | Alkaloid | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000635.1 |  | 0.54 | Terpene | carotenoid | Paracoccus sp. N81106
BGC0000642.1 |  | 0.53 | Terpene | carotenoid | Enterobacteriaceae bacterium DC413

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KB375281.1 - Region 2 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 568,183 - 590,460 nt. (total: 22,278 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001645.1 |  | 0.26 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001634.1 |  | 0.24 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001496.1 |  | 0.23 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001551.1 |  | 0.23 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001655.1 |  | 0.23 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0000575.1 |  | 0.23 | RiPP | lariatin | Rhodococcus jostii
BGC0001889.1 |  | 0.22 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001356.1 |  | 0.22 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0000928.1 |  | 0.18 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.18 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001645.1 |  | 0.59 | RiPP | lagmysin | Streptomyces sp. NRRL S-118
BGC0001634.1 |  | 0.58 | RiPP | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001496.1 |  | 0.57 | RiPP | actinokineosin | Actinokineospora spheciospongiae
BGC0001551.1 |  | 0.56 | RiPP | citrulassin E | Streptomyces glaucescens
BGC0001655.1 |  | 0.56 | RiPP | LP2006 | Nocardiopsis alba DSM 43377
BGC0000575.1 |  | 0.56 | RiPP | lariatin | Rhodococcus jostii
BGC0001889.1 |  | 0.55 | RiPP | fusilassin | Thermobifida fusca YX
BGC0001356.1 |  | 0.55 | RiPP | paeninodin | Paenibacillus dendritiformis C454
BGC0000928.1 |  | 0.49 | Other | T3 toxin | Cylindrospermopsis raciborskii T3
BGC0000188.1 |  | 0.49 | Alkaloid | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KB375281.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 888,388 - 909,251 nt. (total: 20,864 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000698.1 |  | 0.15 | Saccharide | hygromycin A | Streptomyces hygroscopicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000698.1 |  | 0.45 | Saccharide | hygromycin A | Streptomyces hygroscopicus

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KB375281.1 - Region 4 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,233,615 - 2,244,418 nt. (total: 10,804 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001882.1 |  | 0.18 | Polyketide | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255
BGC0001521.1 |  | 0.15 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0000842.1 |  | 0.09 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus
BGC0001890.1 |  | 0.08 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0000132.1 |  | 0.07 | Polyketide | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000446.1 |  | 0.06 | NRP | tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline | Klebsiella oxytoca
BGC0001805.1 |  | 0.06 | NRP | tilivalline | Klebsiella oxytoca
BGC0001055.1 |  | 0.05 | NRP, Polyketide | yersiniabactin | Escherichia coli
BGC0000119.1 |  | 0.05 | Polyketide, Saccharide | 7-deoxypactamycin | Streptomyces pactum
BGC0000133.1 |  | 0.05 | Polyketide | quartromicin A1 | Amycolatopsis orientalis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001882.1 |  | 0.50 | Polyketide | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255
BGC0001521.1 |  | 0.45 | NRP | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0000842.1 |  | 0.34 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus
BGC0001890.1 |  | 0.30 | NRP | amphi-enterobactin 1, amphi-enterobactin 2, amphi-enterobactin 3, amphi-enterobactin 4 | Vibrio campbellii ATCC BAA-1116
BGC0000132.1 |  | 0.28 | Polyketide | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000446.1 |  | 0.25 | NRP | tilivalline, 9-deoxy tilivalline, dihydroxy tilivalline, dehydro tilivalline, dihydroxy-dehydro tilivalline | Klebsiella oxytoca
BGC0001805.1 |  | 0.25 | NRP | tilivalline | Klebsiella oxytoca
BGC0001055.1 |  | 0.23 | NRP, Polyketide | yersiniabactin | Escherichia coli
BGC0000119.1 |  | 0.22 | Polyketide, Saccharide | 7-deoxypactamycin | Streptomyces pactum
BGC0000133.1 |  | 0.22 | Polyketide | quartromicin A1 | Amycolatopsis orientalis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_KB375281.1 - Region 5 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,994,064 - 3,014,486 nt. (total: 20,423 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000766.1 |  | 0.16 | Saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000748.1 |  | 0.16 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000740.1 |  | 0.16 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000747.1 |  | 0.16 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000746.1 |  | 0.16 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000744.1 |  | 0.16 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000745.1 |  | 0.16 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000741.1 |  | 0.16 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000737.1 |  | 0.16 | Saccharide | capsular polysaccharide | Pasteurella multocida
BGC0000770.1 |  | 0.15 | Saccharide | lipo-oligosaccharide | Campylobacter jejuni

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000766.1 |  | 0.47 | Saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000748.1 |  | 0.46 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000740.1 |  | 0.46 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000747.1 |  | 0.46 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000746.1 |  | 0.46 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000744.1 |  | 0.46 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000745.1 |  | 0.46 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000741.1 |  | 0.46 | Saccharide | capsular polysaccharide | Streptococcus agalactiae
BGC0000737.1 |  | 0.46 | Saccharide | capsular polysaccharide | Pasteurella multocida
BGC0000770.1 |  | 0.45 | Saccharide | lipo-oligosaccharide | Campylobacter jejuni

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names