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Overview
1.1
1.2
4.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_HE610996.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS,betalactone | 14,831 | 61,640 | bacillibactin | NRP:NRP siderophore | 60%
Region 1.2 | terpene | 94,395 | 115,222 |

NZ_HE610999.1

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 4.1 | betalactone | 259,004 | 283,098 | fengycin | NRP | 46%

Region | Type | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS,betalactone | 14,831 | 61,640 | bacillibactin | NRP:NRP siderophore | 60%
Region 1.2 | terpene | 94,395 | 115,222 |
Region 4.1 | betalactone | 259,004 | 283,098 | fengycin | NRP | 46%

No secondary metabolite regions were found in these records:
  NZ_HE610997.1
  NZ_HE610998.1
  NZ_HE611000.1
  NZ_HE611001.1
  NZ_HE611002.1
  NZ_HE611003.1
  NZ_HE611004.1
  NZ_HE611005.1
  NZ_HE611006.1
  NZ_HE611007.1
  NZ_HE611008.1
  NZ_HE611009.1
  NZ_HE611010.1
  NZ_HE611011.1
  NZ_HE611012.1
  NZ_HE611013.1
  NZ_CAEU01000072 (original name was: NZ_CAEU01000072.1)

Compact view
NZ_HE610996.1 - Region 1 - NRPS,betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 14,831 - 61,640 nt. (total: 46,810 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX))
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
NRPS/PKS domains
MIBiG comparison
KnownClusterBlast
NRPS/PKS modules
Pfam domains
TIGRFAM domains
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001615.1 |  |  | 0.65 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000457.1 |  |  | 0.61 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001149.1 |  |  | 0.53 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001132.1 |  |  | 0.53 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.1 |  |  | 0.53 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.1 |  |  | 0.53 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0000321.1 |  |  | 0.52 | NRP | chaetocin | Collariella virescens
BGC0001185.1 |  |  | 0.52 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0001131.1 |  |  | 0.51 | NRP | ambactin | Xenorhabdus miraniensis
BGC0001873.1 |  |  | 0.50 | NRP | pyrrolizixenamide A | Xenorhabdus szentirmaii DSM 16338

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001615.1 |  | 0.66 | NRP | hexose-palythine-serine, hexose-shinorine | Heteroscytonema crispum UCFS10
BGC0000457.1 |  | 0.64 | NRP | vicibactin | Rhizobium etli CFN 42
BGC0001149.1 |  | 0.60 | NRP, Saccharide | brabantamide A | Pseudomonas sp. SHC52
BGC0001132.1 |  | 0.60 | NRP | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.1 |  | 0.60 | NRP | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.1 |  | 0.60 | NRP | xenematide | Xenorhabdus nematophila AN6/1
BGC0000321.1 |  | 0.60 | NRP | chaetocin | Collariella virescens
BGC0001185.1 |  | 0.59 | NRP | bacillibactin | Bacillus velezensis FZB42
BGC0000410.1 |  | 0.59 | NRP | pseudomonine | Pseudomonas fluorescens
BGC0001585.1 |  | 0.59 | Alkaloid | melinacidin IV | Escovopsis weberi

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Module view
Shows module structures for each candidate in NRPS- and PKS regions. Genes are shown in predicted order, and are only present when containing at least one complete module. A domain glossary is available here.
Legend
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NRPS/PKS products
NRPS/PKS monomers
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 14830 - 61640:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (gly - thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS monomer predictions
Shows the predicted monomers for each adynelation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).

ctg1_42: gly - thr
  Search NORINE for peptide: strict or relaxed
  AMP-binding (432..815): gly
  NRPSPredictor2: gly
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      gly, ala, val, leu, ile, abu, iva
    Small clusters prediction:
      gly, ala
    Single AA prediction:
      gly
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DILQLGMIWK
    Nearest Stachelhaus code:
      gly
    Stachelhaus code match:
      100% (strong)
  AMP-binding (1435..1830): thr
  NRPSPredictor2: thr
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aliphatic
    Large clusters prediction:
      ser, thr, dhpg, hpg
    Small clusters prediction:
      thr
    Single AA prediction:
      thr
  Stachelhaus prediction details:
    Stachelhaus sequence:
      DFWNIGMVHK
    Nearest Stachelhaus code:
      thr
    Stachelhaus code match:
      100% (strong)
ctg1_44: dhb
  Search NORINE for peptide: strict or relaxed
  AMP-binding (31..435): dhb
  NRPSPredictor2: dhb
  SVM prediction details:
    Predicted physicochemical class:
      hydrophobic-aromatic
    Large clusters prediction:
      dhb, sal
    Small clusters prediction:
      dhb, sal
    Single AA prediction:
      dhb
  Stachelhaus prediction details:
    Stachelhaus sequence:
      PMPAlGVVNK
    Nearest Stachelhaus code:
      dhb
    Stachelhaus code match:
      90% (moderate)

NZ_HE610996.1 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 94,395 - 115,222 nt. (total: 20,828 nt) Show pHMM detection rules used
terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000851.1 |  | 0.19 | Other | albonoursin | Streptomyces noursei ATCC 11455
BGC0000452.1 |  | 0.06 | NRP | tyrocidine | Brevibacillus brevis NBRC 100599
BGC0000727.1 |  | 0.06 | Saccharide | indigoidine | Streptomyces aureofaciens
BGC0001215.1 |  | 0.05 | NRP | conglobatin | Streptomyces conglobatus
BGC0001022.1 |  | 0.04 | NRP, Polyketide | myxalamid | Stigmatella aurantiaca
BGC0000100.1 |  | 0.04 | Polyketide | monensin | Streptomyces cinnamonensis
BGC0001580.1 |  | 0.04 | Polyketide | ebelactone | Kitasatospora aburaviensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000851.1 |  | 0.52 | Other | albonoursin | Streptomyces noursei ATCC 11455
BGC0000452.1 |  | 0.26 | NRP | tyrocidine | Brevibacillus brevis NBRC 100599
BGC0000727.1 |  | 0.24 | Saccharide | indigoidine | Streptomyces aureofaciens
BGC0001215.1 |  | 0.22 | NRP | conglobatin | Streptomyces conglobatus
BGC0001022.1 |  | 0.19 | NRP, Polyketide | myxalamid | Stigmatella aurantiaca
BGC0000100.1 |  | 0.18 | Polyketide | monensin | Streptomyces cinnamonensis
BGC0001580.1 |  | 0.18 | Polyketide | ebelactone | Kitasatospora aburaviensis

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.

No matches found.

Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names
NZ_HE610999.1 - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 259,004 - 283,098 nt. (total: 24,095 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
MIBiG comparison
KnownClusterBlast
Pfam domains
TIGRFAM domains
Similar gene clusters
Shows careas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.1 |  | 0.29 | Other | showdomycin | Streptomyces showdoensis
BGC0000234.1 |  | 0.21 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001897.1 |  | 0.21 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000842.1 |  | 0.19 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus
BGC0000258.1 |  | 0.19 | Polyketide | prodigiosin | Serratia sp.
BGC0002034.1 |  | 0.16 | Other | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0000522.1 |  | 0.16 | RiPP | lacticin Z | Lactococcus lactis
BGC0001343.1 |  | 0.16 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000620.1 |  | 0.16 | RiPP | lacticin Q | Lactococcus lactis
BGC0000634.1 |  | 0.16 | Terpene | carotenoid | Brevundimonas sp. SD212

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.1 |  | 0.63 | Other | showdomycin | Streptomyces showdoensis
BGC0000234.1 |  | 0.54 | Polyketide | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001897.1 |  | 0.53 | Polyketide | cepacin A | Burkholderia ambifaria IOP40-10
BGC0000842.1 |  | 0.52 | Other (Non-NRP beta-lactam) | carbapenem MM4550 | Streptomyces argenteolus
BGC0000258.1 |  | 0.51 | Polyketide | prodigiosin | Serratia sp.
BGC0002034.1 |  | 0.47 | Other | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0000522.1 |  | 0.47 | RiPP | lacticin Z | Lactococcus lactis
BGC0001343.1 |  | 0.47 | Polyketide | aurachin A, aurachin D | Stigmatella aurantiaca Sg a15
BGC0000620.1 |  | 0.47 | RiPP | lacticin Q | Lactococcus lactis
BGC0000634.1 |  | 0.47 | Terpene | carotenoid | Brevundimonas sp. SD212

Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.
Detailed Pfam domain annotation
Shows Pfam domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description. Domains with a bold border have Gene Ontology information.
Selected features only
Expand to show all names
Detailed TIGRFAM domain annotation
Shows TIGRFAM domains found in each gene within the region. Click on each domain for more information about the domain's accession, location, and description.
Selected features only
Expand to show all names