LOCUS       NZ_HE978605.1          10405 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_HE978605.1 Brevibacterium senegalense strain JC43, whole genome
            shotgun sequence.
ACCESSION   NZ_HE978605
VERSION     NZ_HE978605.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:52:43
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 121372
            Orig. end    :: 131777
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10405
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[126372:126777](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5405
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     cand_cluster    1..10405
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10405
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /tool="antismash"
     CDS             2021..2512
                     /locus_tag="ctg6_124"
                     /transl_table=11
                     /translation="MASDSSFDIVSKIDRQEADNALNQAAKEISSRYDFKGSGAAIEWK
                     GEAIQMRADGEDRVTSVLDVFQSKLVRRGISLKSLEAGDPYPSGKEHRIDATLKEGIDK
                     ESAKEISKIIRDEGPKGVKAQIQGDELRVSSKKRDDLQAVIALLKGKDLDVDLQFVNYR
                     "
     PFAM_domain     2033..2509
                     /aSDomain="DUF520"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04461.15"
                     /description="Protein of unknown function (DUF520)"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_124_0001"
                     /evalue="4.50E-62"
                     /label="ctg6_124"
                     /locus_tag="ctg6_124"
                     /protein_end="163"
                     /protein_start="4"
                     /score="209.0"
                     /tool="antismash"
                     /translation="SSFDIVSKIDRQEADNALNQAAKEISSRYDFKGSGAAIEWKGEAI
                     QMRADGEDRVTSVLDVFQSKLVRRGISLKSLEAGDPYPSGKEHRIDATLKEGIDKESAK
                     EISKIIRDEGPKGVKAQIQGDELRVSSKKRDDLQAVIALLKGKDLDVDLQFVNYR"
     CDS             complement(2669..2833)
                     /locus_tag="ctg6_125"
                     /transl_table=11
                     /translation="MATGLRALLSAIVGSSAGVRDVECDPRHVNGDGGERGSWILDATA
                     RWNSSPTTA"
     CDS             2862..3437
                     /locus_tag="ctg6_126"
                     /transl_table=11
                     /translation="VTQADTVHPPTTTPASTASDSPTAAAGTIELRQLSLDDGKHLWTL
                     ARDSKVLDLNTSYAYLLWARDFAATSVLATLDGAPVGFVTGYMRPDSPDTLMIWQVAVD
                     SAARGHGLAGRMLDELAARTGAGRLETTITADNEPSQKLFASFAKRHGAELTTSPLFRP
                     EDYPDGHDTEHLHEIAPLRPAAAGTPAG"
     aSDomain        2955..3404
                     /aSDomain="TIGR02406"
                     /aSTool="tigrfam"
                     /description="ectoine_EctA: diaminobutyrate
                     acetyltransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg6_126_0001"
                     /evalue="4.30E-50"
                     /identifier="TIGR02406"
                     /label="ctg6_126"
                     /locus_tag="ctg6_126"
                     /protein_end="181"
                     /protein_start="31"
                     /score="167.8"
                     /tool="antismash"
                     /translation="RQLSLDDGKHLWTLARDSKVLDLNTSYAYLLWARDFAATSVLATL
                     DGAPVGFVTGYMRPDSPDTLMIWQVAVDSAARGHGLAGRMLDELAARTGAGRLETTITA
                     DNEPSQKLFASFAKRHGAELTTSPLFRPEDYPDGHDTEHLHEIAPL"
     PFAM_domain     3039..3296
                     /aSDomain="Acetyltransf_1"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00583.27"
                     /description="Acetyltransferase (GNAT) family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_126_0002"
                     /evalue="1.20E-10"
                     /label="ctg6_126"
                     /locus_tag="ctg6_126"
                     /protein_end="145"
                     /protein_start="59"
                     /score="41.8"
                     /tool="antismash"
                     /translation="YLLWARDFAATSVLATLDGAPVGFVTGYMRPDSPDTLMIWQVAVD
                     SAARGHGLAGRMLDELAARTGAGRLETTITADNEPSQKLFA"
     CDS             3595..4884
                     /NRPS_PKS="Domain: Aminotran_3 (23-357). E-value: 2.6e-76.
                     Score: 248.6. Matches aSDomain:
                     nrpspksdomains_ctg6_127_Aminotran_3.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 377.2;
                     E-value: 1.6e-114)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_127"
                     /sec_met_domain="Aminotran_3 (E-value: 6.5e-81, bitscore:
                     265.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDIFYSLESEVRSYSRSWPVEFVQASGATQTDSNGTQYLDFFSG
                     AGALNYGHNHPAVMKPLVEYLQSGGVLHGMDMMTPAKREFLQTFKDVILEPRDLHYKVM
                     FPGPTGTNTVEAALKLARKYTGRQHILSFTNAFHGMTLGSLSVTGNSMKRQGAGIPLTN
                     SSKIPYDDYLDGETPDFLWLERVLEDSGSGVDKPAAIIVETVQGEGGLRAARFDWLRRL
                     AELCQEHEILLIVDDVQAGCGRTGTFFSFEEAGITPDIVCLSKSISGSGLPMALTLFRP
                     ELDIWSPGEHNGTFRGNNPAFVTATAALREFWADPSFQSRLADTIDTLQSRIEAIALST
                     SGAGVRGRGLLTGIVFDDPEAATKIAAEAFREGLLLETSGPQDEVVKLMPPLTISAEDL
                     DRGLDILEAAIRTVTGPAVDTPTATEAPAA"
     aSDomain        3601..4827
                     /aSDomain="TIGR02407"
                     /aSTool="tigrfam"
                     /description="ectoine_ectB: diaminobutyrate--2-oxoglutarate
                     aminotransferase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg6_127_0002"
                     /evalue="1.60E-192"
                     /identifier="TIGR02407"
                     /label="ctg6_127"
                     /locus_tag="ctg6_127"
                     /protein_end="411"
                     /protein_start="2"
                     /score="637.6"
                     /tool="antismash"
                     /translation="DIFYSLESEVRSYSRSWPVEFVQASGATQTDSNGTQYLDFFSGAG
                     ALNYGHNHPAVMKPLVEYLQSGGVLHGMDMMTPAKREFLQTFKDVILEPRDLHYKVMFP
                     GPTGTNTVEAALKLARKYTGRQHILSFTNAFHGMTLGSLSVTGNSMKRQGAGIPLTNSS
                     KIPYDDYLDGETPDFLWLERVLEDSGSGVDKPAAIIVETVQGEGGLRAARFDWLRRLAE
                     LCQEHEILLIVDDVQAGCGRTGTFFSFEEAGITPDIVCLSKSISGSGLPMALTLFRPEL
                     DIWSPGEHNGTFRGNNPAFVTATAALREFWADPSFQSRLADTIDTLQSRIEAIALSTSG
                     AGVRGRGLLTGIVFDDPEAATKIAAEAFREGLLLETSGPQDEVVKLMPPLTISAEDLDR
                     GLDILEAAIR"
     aSDomain        3604..4836
                     /aSDomain="TIGR00709"
                     /aSTool="tigrfam"
                     /description="dat: 2,4-diaminobutyrate 4-transaminase"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg6_127_0003"
                     /evalue="1.60E-140"
                     /identifier="TIGR00709"
                     /label="ctg6_127"
                     /locus_tag="ctg6_127"
                     /protein_end="414"
                     /protein_start="3"
                     /score="466.5"
                     /tool="antismash"
                     /translation="IFYSLESEVRSYSRSWPVEFVQASGATQTDSNGTQYLDFFSGAGA
                     LNYGHNHPAVMKPLVEYLQSGGVLHGMDMMTPAKREFLQTFKDVILEPRDLHYKVMFPG
                     PTGTNTVEAALKLARKYTGRQHILSFTNAFHGMTLGSLSVTGNSMKRQGAGIPLTNSSK
                     IPYDDYLDGETPDFLWLERVLEDSGSGVDKPAAIIVETVQGEGGLRAARFDWLRRLAEL
                     CQEHEILLIVDDVQAGCGRTGTFFSFEEAGITPDIVCLSKSISGSGLPMALTLFRPELD
                     IWSPGEHNGTFRGNNPAFVTATAALREFWADPSFQSRLADTIDTLQSRIEAIALSTSGA
                     GVRGRGLLTGIVFDDPEAATKIAAEAFREGLLLETSGPQDEVVKLMPPLTISAEDLDRG
                     LDILEAAIRTVT"
     PFAM_domain     3655..4824
                     /aSDomain="Aminotran_3"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00202.23"
                     /description="Aminotransferase class-III"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_127_0003"
                     /evalue="5.50E-79"
                     /label="ctg6_127"
                     /locus_tag="ctg6_127"
                     /protein_end="410"
                     /protein_start="20"
                     /score="265.8"
                     /tool="antismash"
                     /translation="VEFVQASGATQTDSNGTQYLDFFSGAGALNYGHNHPAVMKPLVEY
                     LQSGGVLHGMDMMTPAKREFLQTFKDVILEPRDLHYKVMFPGPTGTNTVEAALKLARKY
                     TGRQHILSFTNAFHGMTLGSLSVTGNSMKRQGAGIPLTNSSKIPYDDYLDGETPDFLWL
                     ERVLEDSGSGVDKPAAIIVETVQGEGGLRAARFDWLRRLAELCQEHEILLIVDDVQAGC
                     GRTGTFFSFEEAGITPDIVCLSKSISGSGLPMALTLFRPELDIWSPGEHNGTFRGNNPA
                     FVTATAALREFWADPSFQSRLADTIDTLQSRIEAIALSTSGAGVRGRGLLTGIVFDDPE
                     AATKIAAEAFREGLLLETSGPQDEVVKLMPPLTISAEDLDRGLDILEAAI"
     aSDomain        3664..4665
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg6_127_Aminotran_3.1"
                     /evalue="2.60E-76"
                     /label="ctg6_127_Aminotran_3.1"
                     /locus_tag="ctg6_127"
                     /protein_end="357"
                     /protein_start="23"
                     /score="248.6"
                     /tool="antismash"
                     /translation="VQASGATQTDSNGTQYLDFFSGAGALNYGHNHPAVMKPLVEYLQS
                     GGVLHGMDMMTPAKREFLQTFKDVILEPRDLHYKVMFPGPTGTNTVEAALKLARKYTGR
                     QHILSFTNAFHGMTLGSLSVTGNSMKRQGAGIPLTNSSKIPYDDYLDGETPDFLWLERV
                     LEDSGSGVDKPAAIIVETVQGEGGLRAARFDWLRRLAELCQEHEILLIVDDVQAGCGRT
                     GTFFSFEEAGITPDIVCLSKSISGSGLPMALTLFRPELDIWSPGEHNGTFRGNNPAFVT
                     ATAALREFWADPSFQSRLADTIDTLQSRIEAIALSTSGAGVRGRGLLTGIVFD"
     PFAM_domain     5001..5375
                     /aSDomain="Ectoine_synth"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF06339.14"
                     /description="Ectoine synthase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_128_0004"
                     /evalue="1.60E-57"
                     /label="ctg6_128"
                     /locus_tag="ctg6_128"
                     /protein_end="125"
                     /protein_start="0"
                     /score="193.3"
                     /tool="antismash"
                     /translation="MYVVNIDDLNGTERDIVSDNWRSRRMVLAREGVGFSFHETTLFAG
                     TTSTFHYQNHIEAVYCVGGSGTITNEETGEVHELRDGTMYLLDKHDLHTVRTEHEMRMV
                     CVFNPPVTGREVHDENGVYPA"
     CDS             5001..5405
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_128"
                     /sec_met_domain="ectoine_synt (E-value: 9.5e-53, bitscore:
                     171.3, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYVVNIDDLNGTERDIVSDNWRSRRMVLAREGVGFSFHETTLFAG
                     TTSTFHYQNHIEAVYCVGGSGTITNEETGEVHELRDGTMYLLDKHDLHTVRTEHEMRMV
                     CVFNPPVTGREVHDENGVYPALNEDGTPVS"
     CDS             complement(5510..6895)
                     /gene_functions="other (smcogs) SMCOG1285:ferredoxin fdxC
                     (Score: 493.1; E-value: 1.2e-149)"
                     /gene_kind="other"
                     /locus_tag="ctg6_129"
                     /transl_table=11
                     /translation="VAIVGAGPAGIYAADLLTKAERDFEVSIDLFERLPAPFGLVRYGV
                     APDHPRIKGIQKALIKVLDRGDVRLLANVDFGTDITLEDLRGLYDAVIFSTGSFDDARL
                     ELPGIDLPRSYGAADFVNWYDAHPDVPQEWPLDAQRVAVIGNGNVALDVARVLAKQADD
                     MLSTEIPDHVHRGLQASQVTDVHVFGRRGPAQTKFTPLELRELGQVKDVDIVVYPEDYE
                     FDEASMAAIHSNNQTKQVTKALTDFTLREPTGAPRRLHFHFLHAPVEVLGDEQSGVTGL
                     RTERQELDGNGGVVGTGTHHDWPLDAVYRAVGYFGSPLADIPFDARRGVITNVGGRVHR
                     GESQEQAANTPVIPGLYATGWIKRGPVGLIGHTKGDALETITHLIEDRTADLLPVPADP
                     REDAIIELLESRGVDFADWDGFHRLESAEQALGEPQGRERVKIPTRDGMLEHSRRRVDA
                     HVG"
     PFAM_domain     complement(6401..6895)
                     /aSDomain="Pyr_redox_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF07992.16"
                     /description="Pyridine nucleotide-disulphide
                     oxidoreductase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_129_0005"
                     /evalue="5.70E-10"
                     /label="ctg6_129"
                     /locus_tag="ctg6_129"
                     /protein_end="165"
                     /protein_start="0"
                     /score="39.0"
                     /tool="antismash"
                     /translation="VAIVGAGPAGIYAADLLTKAERDFEVSIDLFERLPAPFGLVRYGV
                     APDHPRIKGIQKALIKVLDRGDVRLLANVDFGTDITLEDLRGLYDAVIFSTGSFDDARL
                     ELPGIDLPRSYGAADFVNWYDAHPDVPQEWPLDAQRVAVIGNGNVALDVARVLAKQADD
                     ML"
     CDS             7067..7984
                     /locus_tag="ctg6_130"
                     /transl_table=11
                     /translation="VTTTPELPPDETQRRRAGLLNGAGAYLLWGFLPLYFSALAPAGSL
                     EILAHRIVWCLFFCALLLALTRGYTTVWRILRNPRTTGLLTAASILVGINWLGFLLGVE
                     LGRVVEVSLGYYINPLITILLGVIFLRERLRPLQWAAVAVAFVAVLVISIGYGAVPWLG
                     LLVATTFGGYGLVKNRVGPTVGAVSGLSIETLILVVPAAAYMGWAMATGVSTFTTEGSW
                     HIVLMLLLGPATAVPLLLFSAAARRIPLSWVGMLQFITPTMQFITGVWILGEEMTPARW
                     AGFAIIWVACALFITDMVRASRRR"
     aSDomain        7115..7879
                     /aSDomain="TIGR00688"
                     /aSTool="tigrfam"
                     /description="rarD: protein RarD"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg6_130_0004"
                     /evalue="2.30E-55"
                     /identifier="TIGR00688"
                     /label="ctg6_130"
                     /locus_tag="ctg6_130"
                     /protein_end="271"
                     /protein_start="16"
                     /score="185.8"
                     /tool="antismash"
                     /translation="AGLLNGAGAYLLWGFLPLYFSALAPAGSLEILAHRIVWCLFFCAL
                     LLALTRGYTTVWRILRNPRTTGLLTAASILVGINWLGFLLGVELGRVVEVSLGYYINPL
                     ITILLGVIFLRERLRPLQWAAVAVAFVAVLVISIGYGAVPWLGLLVATTFGGYGLVKNR
                     VGPTVGAVSGLSIETLILVVPAAAYMGWAMATGVSTFTTEGSWHIVLMLLLGPATAVPL
                     LLFSAAARRIPLSWVGMLQFITPTMQFITGVWI"
     PFAM_domain     7118..7525
                     /aSDomain="EamA"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00892.22"
                     /description="EamA-like transporter family"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_130_0006"
                     /evalue="1.60E-10"
                     /label="ctg6_130"
                     /locus_tag="ctg6_130"
                     /protein_end="153"
                     /protein_start="17"
                     /score="41.4"
                     /tool="antismash"
                     /translation="GLLNGAGAYLLWGFLPLYFSALAPAGSLEILAHRIVWCLFFCALL
                     LALTRGYTTVWRILRNPRTTGLLTAASILVGINWLGFLLGVELGRVVEVSLGYYINPLI
                     TILLGVIFLRERLRPLQWAAVAVAFVAVLVIS"
     CDS             complement(8033..9079)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 256.1; E-value:
                     6.1e-78)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_131"
                     /transl_table=11
                     /translation="MMNDPMTPDTAGAPLRTQAGPFAAADSALAFDLAAGLDRVEERLS
                     AAAAQSERLPHEASHHLMQAGGKRVRPLLVLLAAQLGDGTRDEVIDAAAAVELIHLATL
                     YHDDVMDDAPVRRGAPSAHEVWGNSVAILTGDLLFARASLLSSELGPAAVRLQATTFER
                     LVLGQLAEFTGPAPDEDPVAHYLQVLADKTGSLIAASGEFGLRFSGASEEFIEPLRDYG
                     EKVGVAFQLADDIIDLTSDAATSGKRPGTDLRERVPTLPVLYARRAAAGGDTTAAEVVV
                     RLDGDLTSDVALEEARVALAAHPVTQEARAEARRWADEAIAALEALPEGEVREGLEAFA
                     HQVVERSS"
     PFAM_domain     complement(8273..8914)
                     /aSDomain="polyprenyl_synt"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00348.19"
                     /description="Polyprenyl synthetase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg6_131_0007"
                     /evalue="7.80E-58"
                     /label="ctg6_131"
                     /locus_tag="ctg6_131"
                     /protein_end="269"
                     /protein_start="55"
                     /score="195.6"
                     /tool="antismash"
                     /translation="HEASHHLMQAGGKRVRPLLVLLAAQLGDGTRDEVIDAAAAVELIH
                     LATLYHDDVMDDAPVRRGAPSAHEVWGNSVAILTGDLLFARASLLSSELGPAAVRLQAT
                     TFERLVLGQLAEFTGPAPDEDPVAHYLQVLADKTGSLIAASGEFGLRFSGASEEFIEPL
                     RDYGEKVGVAFQLADDIIDLTSDAATSGKRPGTDLRERVPTLPVLYARRAA"
ORIGIN
        1 gttcatcgcg aactccccga aggtggtgcc ggcgcgcagc accgccagga ggctgccgtc
       61 cgcgctgtac gtccgcacct caccggagcg catgaagcgg atgccgtcga accggtcgcc
      121 gatcgcgcgc accgtctcgc cctcgcggta gcgctgctgc accagcagat cgacgacgat
      181 ccgccggtcc tccggctgga gctcgtccag catcggggcg ttcgcgtact ccgggctgta
      241 gaagcacgac tcgtcgccga agtgccgcag caccaggttc tccgcccacg ccagtgcggc
      301 gtagcgcagc cggaaggact cgatccccag gtcctcgagg tgctcctcca gcagatcgtc
      361 cggatcgatg ctcgacaggt cgatgccggc gtcgtccatg gcggcggcca ggcgatggag
      421 gctgtcgagc gtcgaggcgg ccaggttgtc gaccttcgtg aggtcgagga cgacgcacag
      481 cggatcatcc agttccccga tgaggcggga gacggcctcg aatccggcga actggatgtc
      541 gcccaccagt tcgacgaggt gcgcgtggtc accgtgctcg gccagcacca ggtccgcctc
      601 catgggacgg cggacggtcg agtggaccac gtcgatcgtc gcgtgcgcgc ggacggagga
      661 acgccccacc gtcgccgcac ggacgaagtg caggcccagg tccgcggaca tctcctcgtg
      721 cacgatgatg ccgctggcgc tgttgccgtg ctcgtccagc ggcggcgaga acgtcgcgat
      781 gcccagctgt ccgggcagga cggagatgat gccgccgccc acaccgctct tggcgggaag
      841 ccccacggtc gcgacccagt cgccggagtc gtcgtacatg ccgcacgtgg tcatgacgga
      901 gagcacgcgc tcgacgacgt cctccgtgaa cacgcgcctc cccgtgaccg ggttgacacc
      961 caggttggcc agggtcgagg ccatgacgga cagatccgcc gcggtgacgg agacggcgca
     1021 ctgccgcgtg tagtcgtcga acgcgtcccc gggatcgccg tcgatgatcc cccacgagga
     1081 caggaaccac gccaggcccc ggttgtgggc tccctcggcc aggtcctgct cgtagacgtc
     1141 ctgatcgagg gacaggtccc ggcctgcgca ggcggacatc gtctcgagga tccggtcgaa
     1201 caccgtctgc ccctcgtcgg gccgcacgag ggagacggcg gcgatcgcac cgatgttgat
     1261 gagggggttc ttggggcggc cgctgccgga ctcggaggag atgtcgttgt acgcactgcc
     1321 ggagggctcg acgtcgatct tcgagtcgac cgcgtcgaag cccgcgtcca tgagtgcgag
     1381 tgcgtagacg aacaccttgg agatcgactg gatggagaac tccacgcccg cgtcgcccac
     1441 ccggtaggtg tgcccgtctg ccatcgtcat cgcgatgccc atccgcgtgg ggtcggcgcc
     1501 gtagaggacc ttcgcgtgcg cctccggttc cgcagccgca accgtgcggt gccgcgacag
     1561 acgcgtcgct gcgaagggat cggtgccgca gacggtctcg tgcagagaca gcaggtacga
     1621 gtgaacggga gagcgcatgg gcaccagact actgtcaccg cgggcaggcg gaggggtcgt
     1681 catgtgccgg ttccgtcacc gcgtcgggac ggctggggac gcggcctccc ccgggtatgc
     1741 cagaggcccg ccgaccagcg gaaacactgg acgtcgggcc tctgacagcg ggtggcagat
     1801 gtaggattcg aacctacgaa ggctgtgccg gctgatttac agtcagctcc ctttggccgc
     1861 tcgggcaatc tgccgtcgca ctccgaagag cacctgagga atcatacacc tcggacgggg
     1921 gcggcgcgaa tcgaggcgga ccgcccctgg actagcatgg tcggcaccgt gccgcgccgc
     1981 cgcgcggcac ccgtcacgac gcccatcaca ggaggcagcc atggcatcgg attccagctt
     2041 cgacatcgtc agcaagatcg accggcagga ggcggacaac gcgctcaacc aggcggcgaa
     2101 ggagatctcc tcccgctacg acttcaaggg gtccggcgcc gcgatcgagt ggaagggcga
     2161 ggcgatccag atgcgcgcgg acggcgaaga ccgcgtgacc tccgtgctgg acgtgttcca
     2221 gtcgaagctc gtccgtcgcg gcatctcgct caaatccctc gaggcgggcg acccctaccc
     2281 gtccggcaag gagcaccgca tcgacgcgac cctcaaggag ggcatcgaca aggagagcgc
     2341 gaaggagatc tcgaagatca tccgcgacga gggccccaag ggcgtcaagg cgcagatcca
     2401 gggcgacgag ctgcgcgtga gctcgaagaa gcgcgacgac ctccaggcag tcatcgccct
     2461 gctcaagggc aaggatctgg acgtcgacct gcagttcgtc aactaccgct gaggcccctc
     2521 ctctcggttc cgccggggcg cgctgctcgt cagcgcgccc cgatgtgttc gcgggtgcac
     2581 gcagggcggc aacgacagcc ccgcactgac gtgacccacg ccactcttcc tctcagcatc
     2641 cgaacgcatg ataacgaccc gataacggtc acgcggtggt gggactcgag ttccatcggg
     2701 ccgtcgcgtc caggatccac gacccccgct cacccccatc accgttgacg tggcgggggt
     2761 cgcattccac gtcgcgcacc cccgcggaag accccacgat cgcgctcagg agcgcccgca
     2821 ggccggttgc catcgagtct cacgtcgtta ggttggaagg cgtgactcag gcagacacag
     2881 tccatccgcc caccacgacc cccgcctcca cggcctcgga ctccccgacc gccgcagcgg
     2941 gaacgatcga actccgacag ctctcgctgg acgacggcaa gcacctgtgg acgctggccc
     3001 gcgattcgaa ggtgctggat ctcaacacgt cgtacgccta cctcctgtgg gcccgcgact
     3061 tcgcagccac ctccgtcctc gcgacactcg acggggcgcc ggtcggtttc gtcaccggat
     3121 acatgcgccc ggactccccg gacacgctca tgatctggca ggtcgcggtc gactccgcag
     3181 cccgcggaca cggcctggcg ggtcggatgc tcgatgagct ggccgcccgc acgggcgccg
     3241 gacgcctcga gaccacgatc acggcggaca acgagccctc gcagaagctc ttcgcgtcct
     3301 tcgcgaagcg ccacggcgca gagctcacga cttcgccgct gttccgtccg gaggactacc
     3361 cggacgggca cgacacggag catctccacg agatcgcccc cctgcgcccc gcagccgccg
     3421 gcacccccgc cggctgagca cggagcaacc gcggtcaccg caccgcaccc agttcactgg
     3481 gcgccacggg cagccatccc gttccgcgtc cggaccgttc ggtccagcag ccgagaagcg
     3541 gctcccgtcc ggtcgaatcc caggggccag tgccccagga aggtgagaac caccatgacc
     3601 gacatcttct actcgctcga gtccgaggtc cgcagctatt cgcgcagctg gcccgtcgag
     3661 ttcgtccagg cctccggcgc cacgcagacc gattccaacg gcacccagta cctggacttc
     3721 ttctccggag ccggcgcgct caactacggc cacaaccacc cggccgtcat gaagccgctg
     3781 gtcgagtacc tgcagtccgg cggcgtcctc cacggcatgg acatgatgac gccggccaag
     3841 cgcgagttcc tgcagacgtt caaggacgtc atcctggagc cccgcgacct gcactacaag
     3901 gtcatgttcc ccggccccac cggcacgaac accgtcgagg ccgcgctcaa gctggcccgc
     3961 aagtacacgg gccgccagca catcctgtcc ttcacgaacg cgttccacgg catgacgctg
     4021 ggctcgctgt ccgtgaccgg caactcgatg aagcgccagg gcgcgggcat cccgctcacc
     4081 aactcgtcga agatccccta cgacgactac ctggacggtg agacgccgga cttcctctgg
     4141 ctggagcgcg ttctcgagga ctccggttcc ggcgtcgaca agcccgccgc gatcatcgtc
     4201 gagacggtgc agggcgaggg cggactgcgc gcggcccgct tcgactggct gcgccgtctg
     4261 gccgagctgt gccaggagca cgagatcctc ctcattgtcg acgacgtgca ggccggctgc
     4321 ggtcgtacgg gcaccttctt cagcttcgag gaggcgggca tcaccccgga catcgtctgc
     4381 ctgtcgaagt cgatctccgg ctccggcctg ccgatggcgc tcaccctgtt ccgcccggag
     4441 ctggacatct ggtcgccggg cgagcacaac ggcacgttcc gtggcaacaa ccccgcgttc
     4501 gtgacggcca ccgccgcgct gcgcgagttc tgggcggatc cgtccttcca gtcgcgcctg
     4561 gcggacacga tcgacacgct gcagtcgcgc atcgaggcga tcgcgctgtc caccagcggt
     4621 gcgggcgtcc gcggtcgcgg cctgctgacc ggcatcgtct tcgacgatcc ggaggcggcg
     4681 acgaagatcg ccgcggaggc cttccgcgag ggcctgctgc tggagacgtc cggcccgcag
     4741 gacgaggtcg tcaagctcat gccgccgctc accatctccg cagaggacct ggaccgcggc
     4801 ctcgacatcc tcgaggcggc aatccggacc gtcaccggtc ccgcggtgga cacccccacc
     4861 gccaccgagg ccccggccgc ctgatccgtc cggcccaccg caccggtgcc ccgccgcact
     4921 cgtggcgggg caccggtgcg gagccgccgg cggaccccgg gtccgccacc acccttcttc
     4981 gatccgacag gagagcacac atgtacgtcg tgaacatcga cgatctgaac ggcaccgagc
     5041 gcgacatcgt cagcgacaac tggcgcagcc gccgcatggt cctggcccgc gagggcgtgg
     5101 gcttctcgtt ccacgagacc acgctgttcg ccggcaccac ctccacgttc cactaccaga
     5161 accacatcga ggctgtgtac tgcgtgggcg gttccggcac gatcacgaac gaggagaccg
     5221 gcgaggtcca cgagctgcgc gacggcacga tgtacctgct ggacaagcac gacctgcaca
     5281 ccgtgcggac cgagcacgag atgcgcatgg tgtgcgtctt caacccgccg gtcacgggcc
     5341 gtgaggtcca cgacgagaac ggcgtctacc cggcgctcaa cgaggacggc acccccgtct
     5401 cctgacgctc gcctccgtcg ctccgggacg gacacggcga aggccgccgc accgatcggt
     5461 gcggcggcct tcgccgtctg ctctccgctc tcgcgagagc cggggcgggt cagccgacgt
     5521 gtgcgtcgac gcgccggcgg gagtgctcga gcattccgtc gcgcgtgggg atcttgacgc
     5581 gctcgcggcc ctgcggctcg cccagtgcct gctccgcgga ctcgaggcgg tggaagccgt
     5641 cccagtccgc gaagtcgacg ccgcgggact cgagcagctc gatgatcgcg tcctcgcgcg
     5701 gatccgcggg gaccggcagg aggtctgcgg tgcggtcctc gatgaggtgg gtgatcgtct
     5761 ccagcgcatc gcccttcgtg tggccgatga ggcccacggg accgcgcttg atccaccccg
     5821 tcgcgtagag acccgggatg acaggggtgt tcgcggcctg ctcctgcgac tccccgcggt
     5881 gcacgcgtcc cccgacgttc gtgatgacgc cgcgacgggc gtcgaagggg atgtccgcca
     5941 gcggcgagcc gaagtagccc accgcacggt agacggcgtc cagcggccag tcgtggtggg
     6001 tgcccgtgcc cacgacgccg ccgttgccgt ccaactcctg gcgctccgtg cgcagacccg
     6061 tcacaccgga ctgctcgtcc cccagcacct cgacgggcgc gtggaggaag tggaagtgca
     6121 gacggcgggg ggcaccggtg ggctcgcgca gggtgaagtc ggtgagcgcc ttcgtcacct
     6181 gcttcgtctg gttgttcgag tggatcgccg ccatcgaggc ctcgtcgaac tcgtagtcct
     6241 ccgggtacac gacgatgtcg acgtccttga cctgtcccag ctcccgcagc tccagcgggg
     6301 tgaacttcgt ctgggcggga ccgcgccggc cgaacacgtg gacgtccgtc acctgcgagg
     6361 cctgcaggcc ccggtgcacg tggtcgggga tctccgtcga cagcatgtcg tcggcctgct
     6421 tcgccagcac gcgcgccacg tcgagggcga cgttgccgtt gccgatcacc gcgacgcgct
     6481 gcgcgtccag cggccactcc tgcggcacgt ccgggtgcgc gtcgtaccag ttgacgaagt
     6541 ccgcggcgcc gtacgagcgc ggcaggtcga tgcccggcag ctccaggcgc gcgtcgtcga
     6601 acgaaccggt ggagaagatg acggcgtcgt acaggccccg caggtcctcg agcgtgatat
     6661 ccgtgccgaa gtcgacgttc gccagcagtc gcacgtcgcc gcggtccagc accttgatga
     6721 gggccttctg gatgcccttg atgcggggat ggtccggggc gaccccgtag cggaccaggc
     6781 cgaacggggc gggcagccgc tcgaacagat cgatgctgac ctcgaagtcg cgttccgcct
     6841 tggtgaggag gtccgcggcg tagattccgg cggggcctgc tccgacgatc gccacacgaa
     6901 gagctcgact cacgttccac acaccttccg caggcggccg ggtggggccg cctcgactga
     6961 cgagtaccga ccctccatgt tagtcgcacc tcacctgcgg cgccgcgatc cggctcacac
     7021 atgggccaca tgtccggcaa ttcacaggca tcactagagt gagtccgtga ccaccacccc
     7081 cgaactgccc ccggacgaga cgcagcgcag gcgcgcgggc ctcctcaacg gcgccggcgc
     7141 gtacctgctc tggggcttcc tgcccctcta cttctccgcc ctggcgcccg cgggcagtct
     7201 ggagatcctc gcccaccgga tcgtctggtg cctcttcttc tgcgcgctgc tcctggcgct
     7261 cacccgcggc tacacgacgg tgtggcggat cctccgcaac ccgcgcacca cgggcctcct
     7321 gaccgcggcg agcatcctcg tggggatcaa ctggctgggc ttcctgctgg gagtggagct
     7381 gggccgcgtc gtcgaggtct ccctgggcta ctacatcaac ccgctcatca cgatcctcct
     7441 gggcgtgatc ttcctgcgcg agcggctgcg cccgctgcag tgggcggccg tcgccgtcgc
     7501 gttcgtcgcg gtcctcgtca tctcgatcgg atacggggcc gtcccgtggc tgggtctgct
     7561 ggtcgccacg accttcggcg gctacggcct cgtgaagaat cgcgtgggcc ccacggtggg
     7621 cgccgtgagc gggctcagca tcgagacgct catcctcgtg gtcccggcgg ccgcctacat
     7681 gggctgggcg atggcgaccg gggtcagcac cttcacgacg gagggctcgt ggcacatcgt
     7741 cctcatgctc ctgctggggc ccgcgaccgc ggtcccgctg ctgctcttca gcgccgcggc
     7801 acgacgcatc ccgctcagct gggtgggcat gctgcagttc atcacgccca cgatgcagtt
     7861 catcaccggg gtgtggatcc tgggtgagga gatgacgccg gcgcggtggg cgggcttcgc
     7921 gatcatctgg gtcgcgtgcg cgctcttcat cacggacatg gtgcgcgcct cccgccggcg
     7981 ctgacggacc ggcggcgcgc ggtccggtgc acgcgctgcg gaccctcgcc cctcaggagg
     8041 agcgctcgac cacctggtgc gcgaacgcct cgaggccctc gcggacctcg ccctccggca
     8101 gcgcctccag cgcggcgatc gcctcgtcgg cccaccggcg tgcctccgcg cgtgcctcct
     8161 gggtgaccgg gtgcgcggcc agcgcgaccc gcgcctcctc cagcgccaca tcggaggtga
     8221 ggtcgccgtc caaccggacc acgacctcgg cggcggtggt gtcgccccca gcggccgcgc
     8281 ggcgggcgta gaggaccggc agggtgggga cgcgctcgcg caggtccgtg cccggccgct
     8341 tgccggaggt cgcggcgtcc gaggtgaggt cgatgatgtc gtcggcaagc tggaaggcga
     8401 cgcccacctt ctcgccgtaa tcgcgcaggg gctcgatgaa ctcctccgac gcaccggaga
     8461 agcgcaggcc gaactcgccc gaggccgcga tgagcgaccc cgtcttgtcc gccagcacct
     8521 gcaggtagtg ggcgacgggg tcctcgtccg gggcgggccc ggtgaactcc gccagctggc
     8581 ccagaaccag acgctcgaag gtggtcgcct ggaggcggac cgcagccggg cccagttccg
     8641 aggacagcag cgaggcgcgg gcgaagagca ggtctccggt gaggatcgcg acggaattgc
     8701 cccacacctc gtgcgcgctg ggcgcacccc ggcgcacggg cgcgtcgtcc atgacgtcgt
     8761 cgtggtagag cgtggcgagg tggatgagct cgaccgcggc ggccgcgtcg atgacctcgt
     8821 cgcgcgtgcc gtcgcccagc tgcgcggcca gcaggaccag cagggggcgc acccgcttgc
     8881 cgccggcctg catgaggtga tgggacgcct cgtgcggcag ccgctccgac tgggcggctg
     8941 ccgcgctgag ccgctcctcg acccggtcca ggccggcggc gaggtcgaag gccagtgcgg
     9001 agtccgccgc cgcgaagggg cccgcctgcg tgcgcagcgg tgcacctgcc gtatcaggag
     9061 tcatcgggtc gttcatcatc ctcttggtct cagacgtcgc ggacagtatc gcatcactgc
     9121 ggctcagtcg ttggtcgtcg ccgggactgc gcgggtgagc gccgcgatga catgatccat
     9181 cgcgtccgcg tccgcacctt cacgatggat gttgcccagc agcctcacgg cgaagcgcat
     9241 gagcacgtcc acccccatac cgtacttgat gcccaggtcc atgacctcgg gtctgccgat
     9301 cagctgcgcg aacgcgcgac ccagagtgaa gtggccgccg aaccggtcgc ggacgatctg
     9361 cgggtactcc tgcagcccgg cgcgccaccg gtcccgcggc agtcggcggt gggtgtcgat
     9421 gacctccgcc gcgatgcggg cggcctcgag cgcgtagtcg atgccctccc cgttgaaggg
     9481 gctcaccatg ccggccgagt cccccaccag caggagcccg tcgcggaagt ggggcgtgcg
     9541 gttgaacgcc atcggcaggg cggcggagcg gacgggcacc agctgggtgc tcgcgtcgat
     9601 cccccactcg tggcccatcg cctccagcca ctggtccagc accgtccggt agttgacctc
     9661 gccgaactgc ggggacgtgt cgaggattcc caggcccaca ttcacggtgc cgtcgcccag
     9721 ggggaacagc cagccgtagc cgggcatggc ctcgccgccg gattcgcgca gctccagcca
     9781 gctctcgatg tagtcgtcgt cgtgccgcgg ggacgagtgg tacgtgcgga ccgcgacgcc
     9841 catggggcgg tcgtcgcgct tctgtgcccc gtgcgccacc gcgatgcggg acgagacgcc
     9901 gtcgcaggcg acgaccagcg gcgcacggta ctccgcatcc ggccccacct tgcggccgcg
     9961 ctcgtccgtg cccgtcgcgc ggacaccggc gatccagccg tcggaggcga cgatcggctc
    10021 cgtcgccgcg acctgctcga cgaggcgggc accgcggctc tccgcatgac gggcgagggt
    10081 ctcgtccagg cccacgcggg tcttcgtgag gccgtgggcc gggaagccgc ccccgccggg
    10141 ccagtcgatc tccatgcggt ggccgccgcc caccagacgc aggccgcgat tgcggtgcca
    10201 gcccagcgcg gggtccgtgt cgacgcccag gtggtccagt tcgcggaccg cgcggggtgt
    10261 gagtgcgtcg ccgcagatct tgtcgcgcgg gaaggacgac ttctccagca cgaccacgtc
    10321 gaggcccgcg tccgccaggt gcgcggccgt cgcggagccc gccggccccg cgcccacgac
    10381 gacgacatcc gcgtgggtca cgcgc
//
