LOCUS       NZ_HE978602.1          10804 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  NZ_HE978602.1 Brevibacterium senegalense strain JC43, whole genome
            shotgun sequence.
ACCESSION   NZ_HE978602
VERSION     NZ_HE978602.1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.1.1
            Run date     :: 2024-03-14 14:52:43
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 171866
            Orig. end    :: 182670
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10804
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[176866:177670](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5804)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10804
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10804
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(104..1273)
                     /NRPS_PKS="Domain: Aminotran_1_2 (55-384). E-value:
                     1.3e-40. Score: 131.5. Matches aSDomain:
                     nrpspksdomains_ctg3_153_Aminotran_1_2.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 324; E-value: 2.3e-98)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_153"
                     /transl_table=11
                     /translation="MPPINAHVSSLGGSPIRALLALAQDPNVISFGGGAPASESFDVDG
                     IGKSYQRVLEEHGARALQYSSTEGEPELREAIAARMTHNGLHSEADDVLITSGSQQGLG
                     LVGQVILDPDSIVLTENPTFVSALQAFALSRAQFRPVDTDSGGLVPEALEAAILQYQPR
                     AIYLIPTFQNPTGVTMPESRRREVADILARYNIWLIEDDPYSELRYDEWTMTPISADPR
                     LRQKSLYLGTLSKVLAPGLRIGWIRGPQEVLDTLATTKQGTSLQTSTIDQLAAVDWLTH
                     NDLDAKLVPVRAEYRRRRDAMVQGLDAVLPDGYTLNTPMGGMFLWANLPEGFDANESIT
                     DAVQAGVVYIPGAQFYVADPRPSTIRLSFVSNPVETIAEGLERLGTIFR"
     aSDomain        complement(122..1108)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg3_153_Aminotran_1_2.1"
                     /evalue="1.30E-40"
                     /label="ctg3_153_Aminotran_1_2.1"
                     /locus_tag="ctg3_153"
                     /protein_end="384"
                     /protein_start="55"
                     /score="131.5"
                     /tool="antismash"
                     /translation="EHGARALQYSSTEGEPELREAIAARMTHNGLHSEADDVLITSGSQ
                     QGLGLVGQVILDPDSIVLTENPTFVSALQAFALSRAQFRPVDTDSGGLVPEALEAAILQ
                     YQPRAIYLIPTFQNPTGVTMPESRRREVADILARYNIWLIEDDPYSELRYDEWTMTPIS
                     ADPRLRQKSLYLGTLSKVLAPGLRIGWIRGPQEVLDTLATTKQGTSLQTSTIDQLAAVD
                     WLTHNDLDAKLVPVRAEYRRRRDAMVQGLDAVLPDGYTLNTPMGGMFLWANLPEGFDAN
                     ESITDAVQAGVVYIPGAQFYVADPRPSTIRLSFVSNPVETIAEGLERL"
     PFAM_domain     complement(122..1108)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00155.23"
                     /description="Aminotransferase class I and II"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_153_0001"
                     /evalue="4.50E-38"
                     /label="ctg3_153"
                     /locus_tag="ctg3_153"
                     /protein_end="384"
                     /protein_start="55"
                     /score="131.5"
                     /tool="antismash"
                     /translation="EHGARALQYSSTEGEPELREAIAARMTHNGLHSEADDVLITSGSQ
                     QGLGLVGQVILDPDSIVLTENPTFVSALQAFALSRAQFRPVDTDSGGLVPEALEAAILQ
                     YQPRAIYLIPTFQNPTGVTMPESRRREVADILARYNIWLIEDDPYSELRYDEWTMTPIS
                     ADPRLRQKSLYLGTLSKVLAPGLRIGWIRGPQEVLDTLATTKQGTSLQTSTIDQLAAVD
                     WLTHNDLDAKLVPVRAEYRRRRDAMVQGLDAVLPDGYTLNTPMGGMFLWANLPEGFDAN
                     ESITDAVQAGVVYIPGAQFYVADPRPSTIRLSFVSNPVETIAEGLERL"
     CDS             complement(1303..2889)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 60.8; E-value:
                     1.7e-18)"
                     /gene_kind="transport"
                     /locus_tag="ctg3_154"
                     /transl_table=11
                     /translation="VPRTSPLSSAPQTPTTTLNTPAGDRAHLRARGIHHSPGSRPLLTD
                     VDVTVSATTKLAVVGENGSGKTTLLRILTGRLTPDAGTVEHAGTIAIADQELPAPANLT
                     VGALVDAAIRPALDALAAFDEASAALASESPGAPDAYARALDRCVQLDAWDAQRRVDIA
                     LEALGAVTDRTRPLAHLSVGQRYRVRLACVLGAQPELLVLDEPTNHLDTAGLEFLTATL
                     TNRTGGLLLVSHDAALLADTAHEFLDLDPTSDGRPRLYGGGWDGWRTGRDRERDAWQSA
                     YDDQQAEHRRLQEAVDQARGRLTSGWRPDKGTHKHQRQSRAPGVVQALHRREDELRRHA
                     LSVPPPPPRLTVPVGTTQPGAPLLTAAEVAVTDRSPRPVTVRLAGGDRLLVVGPNGAGK
                     STLLAVLAGGLGPDVGSVRRHGAVRVAHVRQEDGPEPGDDPRDHRSPGQLRRRRLTRAL
                     AEEPDVLLLDEPTNHLSMALVDDLLAGLESASGAVVVATHDRQVLRRLSGWPRLDLGAS
                     SCGSREATATM"
     PFAM_domain     complement(1630..1755)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_154_0003"
                     /evalue="1.30E-07"
                     /label="ctg3_154"
                     /locus_tag="ctg3_154"
                     /protein_end="420"
                     /protein_start="378"
                     /score="32.3"
                     /tool="antismash"
                     /translation="VTVRLAGGDRLLVVGPNGAGKSTLLAVLAGGLGPDVGSVRRH"
     PFAM_domain     complement(2266..2763)
                     /aSDomain="ABC_tran"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00005.29"
                     /description="ABC transporter"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_154_0002"
                     /evalue="1.70E-22"
                     /label="ctg3_154"
                     /locus_tag="ctg3_154"
                     /protein_end="208"
                     /protein_start="42"
                     /score="80.5"
                     /tool="antismash"
                     /translation="LTDVDVTVSATTKLAVVGENGSGKTTLLRILTGRLTPDAGTVEHA
                     GTIAIADQELPAPANLTVGALVDAAIRPALDALAAFDEASAALASESPGAPDAYARALD
                     RCVQLDAWDAQRRVDIALEALGAVTDRTRPLAHLSVGQRYRVRLACVLGAQPELLVLDE
                     PTN"
     CDS             3219..4034
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 72; E-value: 8.6e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_155"
                     /transl_table=11
                     /translation="MFAATGREDTRMKATAVPQDSTTRFTGLARIYDRFRPGYPAECLS
                     WLADTLRLGTSCHVADVGAGTGKLSEELVYEGIRTVAIEPNPDMFQVLEAKSATTSLLT
                     AVQATAEDSTLPDASMNLITAGQSFHWFDQQRFRAECRRVLKPGGQVALLWNSRRRDSD
                     FTQATADVFRRHISDFPGFSGDHKVSAEEFDAFFEPDGFEYREFAHDQMLTVDEFLGRN
                     LSATYAPREGDPAYAPLVADLRRLFDEHREVDEVRFPLTTRLFLGGVGV"
     PFAM_domain     3399..3674
                     /aSDomain="Methyltransf_11"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08241.14"
                     /description="Methyltransferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_155_0004"
                     /evalue="7.30E-17"
                     /label="ctg3_155"
                     /locus_tag="ctg3_155"
                     /protein_end="152"
                     /protein_start="60"
                     /score="61.9"
                     /tool="antismash"
                     /translation="DVGAGTGKLSEELVYEGIRTVAIEPNPDMFQVLEAKSATTSLLTA
                     VQATAEDSTLPDASMNLITAGQSFHWFDQQRFRAECRRVLKPGGQVA"
     CDS             4108..4938
                     /locus_tag="ctg3_156"
                     /transl_table=11
                     /translation="MTDAVTQGGIADNTGKFTGLGAIYARSRPGYPAALLDMLVQRVAS
                     GTDGDGAASTAATSVSGPVVADIGAGTGKLTAELLRRDWDVVAVEPNDDMRAALTATIG
                     EADRLTVVGAPAETTGLDAATISLVTVAQAFHWFDIEAFRAECRRILVPGGQVALIWNF
                     RRAEEESVHAVIEAFRARVGGFTGLTLAEKVTDVELAQFYGGSHYQRLEYDNDELITWD
                     TFRERHLSLSFAPKEGDPAREPLVEDLQRIFDRYAVDGLYRFPNSTHVLVGDVR"
     PFAM_domain     4306..4581
                     /aSDomain="Methyltransf_11"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF08241.14"
                     /description="Methyltransferase domain"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_156_0005"
                     /evalue="9.00E-13"
                     /label="ctg3_156"
                     /locus_tag="ctg3_156"
                     /protein_end="158"
                     /protein_start="66"
                     /score="48.8"
                     /tool="antismash"
                     /translation="DIGAGTGKLTAELLRRDWDVVAVEPNDDMRAALTATIGEADRLTV
                     VGAPAETTGLDAATISLVTVAQAFHWFDIEAFRAECRRILVPGGQVA"
     CDS             complement(5001..5804)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Linocin_M18"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_157"
                     /sec_met_domain="Linocin_M18 (E-value: 2e-84, bitscore:
                     277.1, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLHRELAPLSDAAWADLEDEVKQTFRRHIAGRRFVEMPEPRGY
                     EFSSLTTGRVKETGTDVDGVRGRTRVVLPVIELRVPFSVDRDEVDSVARGAVDADWDPA
                     KDAAMRLAKAEDNAVLSGSAHDVGFSGIIAASPHKPIQLQSDIKDLTSSVAEAITALRL
                     DGVAGPYNLLLSAELYTQLAESADEGNPVSAHIQRILGQGRVIWAPAIDGALVVSERGG
                     DYELHIGQDVSIGYDSHDAEKVNLYLQETFTFRVASAEAAVHLAP"
     PFAM_domain     complement(5046..5804)
                     /aSDomain="Linocin_M18"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF04454.14"
                     /description="Encapsulating protein for peroxidase"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_157_0006"
                     /evalue="1.30E-84"
                     /label="ctg3_157"
                     /locus_tag="ctg3_157"
                     /protein_end="253"
                     /protein_start="0"
                     /score="283.6"
                     /tool="antismash"
                     /translation="MNNLHRELAPLSDAAWADLEDEVKQTFRRHIAGRRFVEMPEPRGY
                     EFSSLTTGRVKETGTDVDGVRGRTRVVLPVIELRVPFSVDRDEVDSVARGAVDADWDPA
                     KDAAMRLAKAEDNAVLSGSAHDVGFSGIIAASPHKPIQLQSDIKDLTSSVAEAITALRL
                     DGVAGPYNLLLSAELYTQLAESADEGNPVSAHIQRILGQGRVIWAPAIDGALVVSERGG
                     DYELHIGQDVSIGYDSHDAEKVNLYLQETFT"
     CDS             complement(5921..7192)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg3_158"
                     /sec_met_domain="Abi (E-value: 1.3e-14, bitscore: 48.9,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDAVPPPPPPNPGPAPEGPVPGGPPPPQDPTQQRAQQPAQQSAQ
                     PHPPAQHHPAPNEAALQYAAQVQAAARGPVAPLPGLPFTSSYRTPRTGWWRGLVSIVLV
                     IVAILTFSFILSFVAIAVDLALGNADTDALMEGQVSMSPTLLAATNVSLLASAAVAFLA
                     HRFLIGLRWGHFHSVVGRFRWSWLALAAAVVVPVYLLFAASSFLDPTYQDLQIDGTVVA
                     FIGIIILTTPLQAAAEEYMFRGVVQRSAGSWVRSPRWSFILGTAVSAPLFAVFHFAQDP
                     WLIFYYLCFGILLSILTQLTGGLEAAIAIHIANNLFLLLVGALAGQMTEGFDRSAGQGG
                     PFMLVPLVILAVVIVVLWLLGRRRKVETTTAEAAAPAAPVSPAAPASPGEAGPSVHGQP
                     AAHLGQPGAGSSQPHADPGQHPDQ"
     PFAM_domain     complement(6245..6517)
                     /aSDomain="Rce1-like"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF02517.18"
                     /description="Type II CAAX prenyl endopeptidase Rce1-like"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_158_0007"
                     /evalue="2.70E-12"
                     /label="ctg3_158"
                     /locus_tag="ctg3_158"
                     /protein_end="316"
                     /protein_start="225"
                     /score="47.0"
                     /tool="antismash"
                     /translation="IIILTTPLQAAAEEYMFRGVVQRSAGSWVRSPRWSFILGTAVSAP
                     LFAVFHFAQDPWLIFYYLCFGILLSILTQLTGGLEAAIAIHIANNL"
     CDS             7391..9529
                     /locus_tag="ctg3_159"
                     /transl_table=11
                     /translation="MANRLAHATSPYLNQHADNPIDWHVWGPEAFEEAARRDVPVLVSI
                     GYATCHWCHVMARESFSDPELGALANESVVAIKVDREELPAVDGFYMDALLAMRGQGGW
                     PLTVFTTPDSRPFFAGTYFPPQPRDGMPSLSQVITTIARTWRDDRDRAQQIASQLAQNL
                     IRLPDLSLGLPAEAPTPQIDDDTLTAAAENLLAAQDRRWGGFGQAPKFPPLLSIVHLLR
                     RHARLGTSPEAADLDAVRRTFAGIASGGIRDHVDGGISRYSVDAQWHIPHFEKMLFDNA
                     QYLRAAVDWLETERRWDPDSRYARLAHREATETAAFLLERMQLPDGGFASGLDADSVDD
                     AGERTEGAYYLETADGVPAPFQPLGPVEAAHPDRPFAVGFPTVAEWAHGEDGSDEESSE
                     DVAPWATPEAVAAREEIAGRRADRPLPQRDDKLVTEWNALAITALAQAGRVLDDERLTT
                     AARRAFDAVLAANRGDAPAAGDATAPTDGAPAGTRPTTDATGGADAGAESGPRVVRSST
                     DGVAGPGQATLADVAQLSIAAHAVGETEAFDSLVREALGFVVFPVRQDGTDEPATRRGQ
                     ATAQGAAVSGTGEPGTDGTAASGTAGAQRWEGASLLDAHGDGIVPVRGSDPLDDSTPSG
                     RAALIEALRLADERAGDRTADHADDADRADAADLRQLRAILLASVLPALQQATRSLGWV
                     LAEAELDAATRSQSDPLA"
     PFAM_domain     7397..7879
                     /aSDomain="Thioredox_DsbH"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF03190.17"
                     /description="Protein of unknown function, DUF255"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_159_0008"
                     /evalue="2.30E-65"
                     /label="ctg3_159"
                     /locus_tag="ctg3_159"
                     /protein_end="163"
                     /protein_start="2"
                     /score="219.6"
                     /tool="antismash"
                     /translation="NRLAHATSPYLNQHADNPIDWHVWGPEAFEEAARRDVPVLVSIGY
                     ATCHWCHVMARESFSDPELGALANESVVAIKVDREELPAVDGFYMDALLAMRGQGGWPL
                     TVFTTPDSRPFFAGTYFPPQPRDGMPSLSQVITTIARTWRDDRDRAQQIASQLAQNL"
     misc_feature    9521..9523
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             9534..9974
                     /locus_tag="ctg3_160"
                     /transl_table=11
                     /translation="MSTHTITSENLQSTIADNDIVILDFWADWCGPCKSFAPVFEQASE
                     QHTDIAFGKIDTEDQQQMAAAFGISSIPTLMVFREGVGVFRQAGALPAPQLEELISGVR
                     GLDMEDVHAKVAEQQKKMAEEQAAKESQQGTGGAPGTSPTDF"
     PFAM_domain     9540..9833
                     /aSDomain="Thioredoxin"
                     /aSTool="clusterhmmer"
                     /database="34.0"
                     /db_xref="PF00085.22"
                     /description="Thioredoxin"
                     /detection="hmmscan"
                     /domain_id="clusterhmmer_ctg3_160_0009"
                     /evalue="9.20E-26"
                     /label="ctg3_160"
                     /locus_tag="ctg3_160"
                     /protein_end="100"
                     /protein_start="2"
                     /score="89.9"
                     /tool="antismash"
                     /translation="THTITSENLQSTIADNDIVILDFWADWCGPCKSFAPVFEQASEQH
                     TDIAFGKIDTEDQQQMAAAFGISSIPTLMVFREGVGVFRQAGALPAPQLEELI"
     aSDomain        9552..9836
                     /aSDomain="TIGR01068"
                     /aSTool="tigrfam"
                     /description="thioredoxin: thioredoxin"
                     /detection="hmmscan"
                     /domain_id="TIGRFam_ctg3_160_0001"
                     /evalue="1.30E-32"
                     /identifier="TIGR01068"
                     /label="ctg3_160"
                     /locus_tag="ctg3_160"
                     /protein_end="101"
                     /protein_start="6"
                     /score="110.0"
                     /tool="antismash"
                     /translation="TSENLQSTIADNDIVILDFWADWCGPCKSFAPVFEQASEQHTDIA
                     FGKIDTEDQQQMAAAFGISSIPTLMVFREGVGVFRQAGALPAPQLEELIS"
ORIGIN
        1 gcttccatcg gaggaacctt cccgggaggg tcggaggggc acggcgctgg ccgcgcgcac
       61 ggaactatgg cctcagtctg tcactcccac ggcctcggcg aggtcagcgg aagatcgtgc
      121 ccagcctctc cagcccctcc gcgatcgtct cgacagggtt ggagacgaag ctcagccgga
      181 tggtcgacgg acgcggatct gcgacgtaga actgcgcgcc ggggatgtag acgacgcccg
      241 cctgcaccgc gtcggtgatc gactcgttcg cgtcgaagcc ctccggcagg ttggcccaca
      301 ggaacatgcc gcccatgggg gtgttgagcg tgtacccgtc gggcaggacg gcgtcgaggc
      361 cctgcaccat cgcgtcgcga cggcgccggt actccgcccg cacgggcacc agcttcgcgt
      421 ccaggtcgtt gtgggtgagc cagtcgaccg ccgccagctg gtcgatcgtc gacgtctgca
      481 gcgacgttcc ctgcttcgtc gtcgcgagcg tgtcgagcac ctcctggggc ccgcggatcc
      541 acccgatccg cagacccggc gccagcacct tcgacagcgt ccccaggtac agggacttct
      601 gccgcaggcg cgggtccgcg ctgatggggg tcatcgtcca ctcgtcgtac cgcagctccg
      661 agtacgggtc gtcctcgatg agccagatgt tgtagcgggc caggatgtcc gcgacctcgc
      721 gcctgcggga ttccggcatc gtcaccccgg tggggttctg gaaggtgggg atgaggtaga
      781 tcgcccgcgg ctggtactgc aggatggcgg cctcgagcgc ctccggcacc agtccgccgg
      841 aatccgtgtc gacgggccgg aactgggcgc gcgacagggc gaacgcctgc agggcggaca
      901 cgaacgtggg gttctccgtc aggacgatcg agtccggatc gaggatcacc tgtccgacga
      961 gtcccaggcc ctgctgagag ccggacgtga tgagcacgtc gtccgcctcc gagtgcagcc
     1021 cgttgtgcgt catccgcgcg gcgatcgcct cgcgcagctc cggttcgccc tccgtcgacg
     1081 agtactggag cgcgcgggcc ccgtgctcct ccagcacccg ttgatacgac ttgccgatcc
     1141 cgtcgacgtc gaagctctcg ctggccggcg cccctccgcc gaagctgatg acgttcggat
     1201 cctgcgcgag cgccagcagc gcgcggatgg gggagccgcc cagcgaggac acgtgcgcgt
     1261 tgatcggcgg catcgggagg tgctgtgcac gagtgaccat gctcacatgg tggcggtcgc
     1321 ctcccgtgat ccgcaagagg acgcgcccag atccagtcgt ggccagcccg acaggcgccg
     1381 cagcacctgc cgatcgtggg tcgcgacgac gacggcgccg ctcgcggact cgaggcccgc
     1441 cagcaggtcg tcgaccagcg ccatcgacag gtggttcgtg ggttcgtcca gcaggagcac
     1501 gtccggttcc tccgcgagcg cacgggtcag ccgccgcctg cgcagctgcc ccggcgaccg
     1561 gtggtcgcgc ggatcgtcgc cgggctcggg cccgtcctcc tggcgcacat gcgcgacgcg
     1621 gaccgcaccg tgccggcgca ccgaccccac atcgggcccg aggccgcccg ccagtaccgc
     1681 gagcagcgtc gacttgcctg cgccgttggg gccgacgacc agcagccggt caccgccggc
     1741 cagccggacg gtcaccggac gcggggagcg gtcggtgacc gcgacctcgg cggcggtgag
     1801 cagcggcgcg ccgggctggg tggtgcccac cggcacggtc agccgcggtg ggggcggggg
     1861 cacgctgagg gcgtggcggc gcagctcgtc ctcgcgacgg tgcagtgcct gcacgactcc
     1921 gggcgcgcgc gactgacgct ggtgcttgtg ggtgcccttg tccggtcgcc agccggaggt
     1981 gaggcggccg cgggcctggt cgacagcctc ctggaggcgc cggtgttcgg cctgctggtc
     2041 gtcgtaggcg gactgccagg cgtcgcgctc gcggtcccgt ccggtccgcc agccgtccca
     2101 gccgccgccg tacagccggg gccgtccgtc ggacgtgggg tcgaggtcca ggaactcgtg
     2161 ggccgtgtcc gccagcaggg ccgcgtcgtg ggagacgagg agcaggccgc ccgtgcggtt
     2221 ggtgagggtg gcggtgagga actcaaggcc ggcggtgtcg aggtggttcg tgggctcgtc
     2281 gaggaccagc agctccggct gcgcgcccag gacgcaggcc agtcgcacgc ggtaccgctg
     2341 gcccacggac aggtgcgcca acgggcgcgt gcggtcggtg accgcgccca gcgcctcgag
     2401 ggcgatgtcg acccgtcgct gcgcgtccca ggcgtccagc tgcacgcacc ggtcgagggc
     2461 gcgggcatag gcgtccgggg cgccggggga ctccgatgcc agggcggcgc tggcctcgtc
     2521 gaaggcggcg agggcgtcga gggccgggcg gatcgccgcg tcgaccagtg caccgacggt
     2581 caggttggcg ggtgcgggca gttcctggtc cgcgatcgcg atcgtgccgg cgtgctcgac
     2641 ggtgcccgcg tccggggtca ggcggcccgt gaggatgcgc agcagcgtcg tcttgccgct
     2701 gccgttctcg cccacgaccg ccagcttcgt cgtcgcggac acggtcacgt cgacatccgt
     2761 gaggagggga cgcgatccgg gggagtggtg gatgccgcgg gcacgcaggt gggcgcggtc
     2821 gccggcgggg gtgttcagag tggtcgtggg ggtctgcggg gcagacgaga ggggagatgt
     2881 gcggggcacg gatcctcctg gatgcaggca cgctgacggt gccggtcgga tggaatgcgt
     2941 ccgacagcgg aggagagggg tgtgagaacc gggtcgcgtc cgccgtcagc ggcgggtgcg
     3001 gagccgtccg tgcaacatca tgcggacaag gctacgggcc gtggggagag ggaggcaagg
     3061 tcaggtgcgg tgtgatgtgc ctgccgcggg tgtgaggtat ccgtcatgaa ttcaggcgtt
     3121 cttcatacga ttctctgggt actctcgaaa gtgacgaccg ggtcggtgcg tccatcgacc
     3181 gacccgaccg ccgtcttcat cgtcagacct gctcgccgat gttcgcggcg accggcaggg
     3241 aggacaccag gatgaaagcg actgcagtgc cgcaggactc gacgacgcgc ttcaccgggc
     3301 tggcgcggat ctacgacagg ttccggccgg gctacccggc ggagtgcctg agctggctgg
     3361 ccgacacact gcgcctgggc acctcgtgcc acgtggcgga tgtgggtgcc ggcaccggca
     3421 agctgtcgga ggaactggtc tacgagggca tccggaccgt cgcaatcgag cccaacccgg
     3481 acatgttcca ggtgctcgag gcgaagtccg cgaccaccag cctcctcacc gcggtgcagg
     3541 cgacggcaga ggactcgacg ctgcccgacg cctccatgaa cctcatcacc gccgggcagt
     3601 cgttccactg gttcgaccag cagcgcttcc gggcggagtg ccgccgtgtg ctcaagccgg
     3661 gcggacaggt cgcgctcctg tggaactcgc gcaggcgcga cagcgacttc acgcaggcca
     3721 ccgctgacgt gttccgccgc cacatctccg acttcccggg cttcagtggc gaccacaagg
     3781 tgagtgcgga ggagttcgac gcgttcttcg agcccgacgg cttcgagtac cgcgagttcg
     3841 cccacgacca gatgctcacg gtcgacgagt tcctgggccg caacctgtcc gcgacctatg
     3901 cgccccgcga gggcgacccg gcgtacgctc cgctggtcgc ggacctgcgc cggctgttcg
     3961 acgagcaccg cgaagtcgac gaggtgcgct tcccgctcac gacccgcctg ttcctgggcg
     4021 gcgtgggggt ctgactgccg gacatgtgct ccaaatctca acgatctggg ccatgatggt
     4081 ggtcgtgaca cgagaggacg accaccgatg accgatgcag tgacccaggg cgggatcgcc
     4141 gacaacaccg ggaagttcac gggattgggt gcgatctacg cgcgcagccg tccgggatac
     4201 cccgccgcgc tgctggacat gctggtccag cgggtggcga gcggaacgga cggggatggt
     4261 gcggcttcga ctgcggcgac ctcggtgtcc gggccggtcg tcgcggatat cggtgccggc
     4321 acgggcaagc tcaccgcaga gctgctgcgc cgcgactggg atgtcgtcgc cgtcgagccc
     4381 aacgacgaca tgcgcgcggc gctcaccgcg acgatcgggg aggcggaccg gctcaccgtc
     4441 gtgggtgctc cggccgagac gaccggcctg gacgcggcga ccatctcgtt ggtgaccgtc
     4501 gcgcaggcgt tccactggtt cgacatcgag gccttccgcg cggagtgccg acgcatcctg
     4561 gtgccgggcg ggcaggtggc gctcatctgg aacttccgcc gtgcggagga ggagtccgtc
     4621 cacgcggtca tcgaagcgtt ccgtgcccgc gtgggaggat tcaccggact cacgctcgca
     4681 gagaaggtga cggacgtgga gctggcgcag ttctacggcg gatcgcacta ccagcggctc
     4741 gagtacgaca acgacgagct catcacgtgg gacacgttcc gcgagcgcca tctgtcgctg
     4801 tccttcgcgc ccaaggaggg cgacccggcc cgcgagccgc tcgtcgagga cctgcagcgg
     4861 atcttcgatc ggtacgcggt cgacggcctc taccgcttcc ccaactccac gcacgtcctg
     4921 gtgggcgacg tgcgctgagg ccgcgagact ccggcggccg gtcgcgtgaa tgcgtcagcc
     4981 gaccgccgga gcgcgcggac tcagggtgcc aggtggaccg cggcctcggc gctggcgacg
     5041 cggaaggtga aggtctcctg caggtacagg ttcaccttct ccgcatcgtg cgagtcatag
     5101 ccgatggaga cgtcctggcc gatgtgcagc tcgtagtcgc cgccgcgctc ggagacgacc
     5161 agggcgccgt cgatcgcggg tgcccagatg acgcggccct ggcccaggat gcgctggatg
     5221 tgagcggaga cggggtttcc ctcgtcggcc gactcggcca gctgggtgta gagctcggcc
     5281 gacagcagca ggttgtaggg gccagcgaca ccgtcgaggc ggagagccgt gatggcctcg
     5341 gcgactgacg acgtgaggtc cttgatgtcc gactgcagct ggatgggctt gtgcgggctg
     5401 gcggcgatga tgccggagaa gcccacgtcg tgtgcggaac cgctcagcac cgcgttgtcc
     5461 tccgccttcg ccaggcgcat cgcggcgtcc ttcgccggat cccagtccgc gtccaccgcg
     5521 ccgcgggcga cgctgtcgac ctcgtcgcgg tcgacggaga acggcacgcg cagctcgatg
     5581 accggcagca cgacgcgggt gcggccgcgc acgccgtcga cgtccgtgcc ggtctccttg
     5641 acgcgtcccg tggtgagcga ggagaactcg tatccgcggg gctcgggcat ctcgacgaag
     5701 cggcggcccg cgatgtgccg gcggaaggtc tgcttgacct cgtcctccag atccgcccag
     5761 gcggcgtcgg acaggggtgc gagttcacga tgaaggttgt tcatggtcgt ccctcctcag
     5821 gatcgtgccg aggtccgcgt cccgaagttc gtgagcgcct cgttttcttg agtgattcta
     5881 gtttactgcg gatcgaggtg gtctaccagt gagtatgcac tcactgatcc gggtgctgtc
     5941 cagggtctgc atgcggctgg ctggagcctg ctcccggctg gccgagatgc gcggccggct
     6001 ggccatggac ggacggtccg gcctcgccgg gtgaggcagg cgcggcaggt gagacgggcg
     6061 cggcaggggc ggcggcctcg gcggtggtgg tctccacctt ccgacgcctg cccagcagcc
     6121 agaggacgac gatcacgacg gcgaggatga cgagcggcac cagcatgaat ggtccgccct
     6181 ggccggcgga gcggtcgaag ccctccgtca tctggccggc cagcgcgccg accagcagga
     6241 ggaagaggtt gttcgcgatg tggatggcga tggcggcctc gagcccgccg gtcagctgcg
     6301 tgaggatcga gaggaggatg ccgaagcaca ggtagtagaa gatgagccac ggatcctggg
     6361 cgaagtggaa gacggcgaac agcggcgcgc tcacggcggt gccgaggatg aaggaccagc
     6421 gcggtgagcg gacccagctg ccggccgagc gctggacgac gccgcggaac atgtactcct
     6481 cggcggcggc ctggagcggg gtcgtgagga tgatgatgcc gatgaaggcg acgacggtgc
     6541 cgtcgatctg caggtcctga tacgtgggat cgaggaagct cgacgcggcg aacagcaggt
     6601 agaccggcac gacgaccgcg gcagcgaggg ccagccatga ccagcggaac cggccgacga
     6661 cggagtggaa gtggccccag cgcagaccga tgaggaagcg gtgggcgagg aacgcgactg
     6721 ccgcggaggc caggaggctc acgttggtcg cggcgagcag cgtcggcgac atggacacct
     6781 gcccctccat gagagcgtcc gtgtccgcgt tgcccagggc caggtcgacc gcgatcgcga
     6841 cgaagctcag gatgaaggag aacgtcagga tcgccacgat gacgaggacg atgctgacca
     6901 aaccgcgcca ccaacccgtg cgcggtgtgc ggtaggacga ggtgaagggg agacccggca
     6961 ggggcgcgac aggcccgcgg gcggcggctt gcacttgggc ggcgtactgc agtgcggcct
     7021 cattcggtgc ggggtgatgc tgagccggcg ggtggggctg cgccgattgc tgcgccggct
     7081 gctgtgcccg ttgctgagtc gggtcctgcg gcggcggagg cccgcctggt accggtcctt
     7141 ccggtgcggg tccgggattg ggcgggggcg gcgggggcac agcatcgctc atggactcac
     7201 cctatccggg cacagggcgc gctgatcggg tgaatcgcct gctggtggca cgaccgacca
     7261 cgtgccacca ccgccgcgcc ctctgtgccg ccttccgtgc acccactagt gtggatggac
     7321 cagggaccgt cgtatccgca caccatcggg gcccgcagga tgcctgtgcc cctcgtcagg
     7381 agacagagga atggccaacc gcctcgccca cgcgaccagc ccgtacctca accagcacgc
     7441 ggacaacccg atcgactggc atgtctgggg gccggaggcg ttcgaggagg ccgcccgccg
     7501 cgacgtcccc gtcctcgtga gcatcggcta cgcgacctgc cactggtgcc acgtcatggc
     7561 ccgcgagtcc ttctcggacc cggaactggg cgccctggcg aacgagtccg tcgtcgcgat
     7621 caaggtcgac cgggaggagc tgcccgccgt cgacggtttc tacatggacg ccctgctggc
     7681 gatgcgcggc cagggcgggt ggccgctcac cgtcttcacg accccggaca gccgcccgtt
     7741 cttcgccggc acctacttcc cgccccagcc gcgcgacggc atgcccagcc tgtcgcaggt
     7801 catcacgacg atcgcgcgca cgtggcggga cgaccgcgat cgggcccagc agattgcctc
     7861 ccagctcgcg cagaacctca tccgcctccc ggacctgtcg ctgggactgc ccgccgaggc
     7921 ccccactcct cagatcgacg acgacaccct gactgcggcg gccgagaacc tcctggccgc
     7981 ccaggaccgt cgctggggcg gcttcgggca ggcccccaag ttcccgccgc tgctgagcat
     8041 cgtccacctg ctgcgccggc acgcacggct gggcacttcg cccgaggccg cggacctgga
     8101 cgccgtccgc cgcacgttcg cgggcatcgc ctccgggggg atccgggacc acgtggatgg
     8161 cgggatctcc cgctacagcg tcgacgcgca gtggcacatc ccccacttcg agaagatgct
     8221 cttcgacaac gcgcagtacc tgcgggccgc cgtcgactgg ctggagacgg agcgtcgctg
     8281 ggacccggat tcccgctacg cccggctggc gcaccgggag gcgacggaga ccgccgcgtt
     8341 cctgctggag cggatgcagc tgccggacgg cggcttcgcc tcggggctgg acgcggactc
     8401 ggtggacgac gccggtgagc gcaccgaggg ggcgtactac ctggagaccg cggacggggt
     8461 gcccgccccg ttccagcccc tgggcccggt cgaggccgcg cacccggacc gccccttcgc
     8521 ggtgggcttc cccacggtcg cggagtgggc gcacggggag gatggctccg acgaggagag
     8581 ctccgaggac gtcgctccct gggcaacccc ggaggccgtc gccgcccgcg aggagatcgc
     8641 cggcaggcgc gccgaccgac cgctgccgca acgcgacgac aagctcgtga cggagtggaa
     8701 cgcgctcgcc atcaccgcgc tcgcccaggc cggtcgcgtc ctggacgacg agcggctcac
     8761 cactgcggcg cggcgcgcct tcgatgcggt cctcgcggcg aaccgcggtg acgccccagc
     8821 agccggcgac gcgaccgcac ccaccgatgg agctccggcc ggcacgaggc cgaccacgga
     8881 tgcgacgggc ggtgccgacg cgggtgcgga atcaggtccc cgcgtcgtcc gcagcagcac
     8941 ggatggagtc gccggtcccg gccaggcgac cctggcggac gtcgcgcagc tgtcgatcgc
     9001 ggcgcacgcg gtgggggaga cggaggcgtt cgactcgctc gtgcgcgagg cgctgggttt
     9061 cgtcgtcttc ccggtccggc aggacgggac ggacgagccg gcgacccggc gggggcaggc
     9121 gaccgcacag ggcgcggcag tctcgggaac aggggagccg ggaacggacg gcacggcggc
     9181 ctcgggaacg gccggcgcac agcgctggga gggtgcgagc ctgctcgacg cgcacggtga
     9241 cgggatcgtg ccggtgcgcg gctcggaccc gttggacgat tcgacgccct ccgggcgggc
     9301 ggccctcatc gaggcgctgc ggctggcgga cgagagggcc ggtgaccgga ccgcggacca
     9361 tgcggacgat gcggaccgcg ccgacgccgc ggacctgcga cagctgcgtg cgatcctgct
     9421 cgcctccgtg ctgccggcgc tgcagcaggc gacccggtcg ctggggtggg tgctggcgga
     9481 ggcggagctg gacgccgcga cccgttctca gtcggatccg ttagcgtgag ggaatgagca
     9541 cgcacacgat cacgtcagag aacctgcagt ccaccatcgc ggacaacgac atcgtcatcc
     9601 tcgacttctg ggccgactgg tgcgggccct gcaagagctt cgccccggtc ttcgagcagg
     9661 cgtcggagca gcacacggac atcgccttcg gcaagatcga cacggaagac cagcagcaga
     9721 tggccgccgc gttcggcatc tcctcgatcc ccactctcat ggtcttccgc gagggcgtgg
     9781 gtgtcttccg ccaggccggc gcgttgcccg ccccgcagct ggaggagctc atcagcggtg
     9841 tgcgcggcct cgacatggag gacgtgcacg cgaaggtcgc ggagcagcag aagaagatgg
     9901 cggaggagca ggcggcgaag gagtcccagc agggcaccgg cggagcgccg ggcacctcgc
     9961 ccacggactt ctgagcgacg gacccccgag cgacggtcgg atgggcggag gcccgcccag
    10021 ccgaccgtca gtcagctcgc caggaaccgg cccagagccg cgcggaggtc ggccaggtcg
    10081 gacagcgcgc acatctcgcg cgccgaatgc atcgaccaca gcgccggccc cacatccacc
    10141 gtcgtcatgc ccagtcgcgt cgcggtgagc gggccgatcg tcgacccgca cgggatcgtg
    10201 ttgttcgaga cgaactcctg gaagcccacc ccggcgtcgc ggcacgcccg cgcccacacg
    10261 gcggtcccca ccgcgtccgt cgcgtagcgc tgctgcgcgt tgatcttcag cagcggtccg
    10321 ccgcccagga ccggccggtt caccgggtcg tggtgcccct ggtagttggg gtgcaccgcg
    10381 tgccccgcgt cggaggacac gcacacggat ccggacagtg cccggaggtg ggccgtccga
    10441 tcgccgccca gtcccgcggt gatccgctcg aggacgtcgg ccaggaacgg gccgctcgca
    10501 ccggaccgcg tctccgaccc cacctcctcg tggtcgaacg ccgccagcac cgcgatcccc
    10561 gtgaggtcgg ccggatcaac ctgtgccagc gcactcgtgc ccgcccacac ggaggccagg
    10621 ttgtcgagcc gcggcgacgc gaggaactcg ctgtgcgcgc cgaacaccgc cggctcctgc
    10681 acggggaacg tgtggacgtc gtagccggcg acgtctgcga cgtcgacccc cgccgaggcc
    10741 gccagcagcc ccagcaccag cgaccccgcc gcgtggtcgg tgtcggtggt gccggacatc
    10801 gcgc
//
